Results 51 to 60 of about 7,029,797 (363)

Fibroblast growth factors [PDF]

Current Biology, 2003
What are they? Fibroblast growth factors (FGFs) are a family of small (20–30kDa) intercellular signalling proteins which are frequently found to be glycosylated. The first draft of the human genome identified 29 potential FGF genes, and so far transcripts have been identified for 23 of them.
openaire   +4 more sources

Growth Factor Regulation of Growth Factors in Articular Chondrocytes [PDF]

Journal of Biological Chemistry, 2009
Several lines of evidence indicate that polypeptide growth factors are important in articular cartilage homeostasis and repair. It is not yet clear how these growth factors are regulated. We tested the hypothesis that the growth factors responsible for regulating cartilage are themselves regulated by growth factors.
George J. Eckert, Shuiliang Shi, Stephen B. Trippel, Scott Mercer   +3 more
openaire   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Neuroprotection: Pro-survival and Anti-neurotoxic Mechanisms as Therapeutic Strategies in Neurodegeneration

Frontiers in Cellular Neuroscience, 2019
Neurotrophins (NTs) are a subset of the neurotrophic factor family. These growth factors were originally named based on the nerve growth functional assays used to identify them. NTs act as paracrine or autocrine factors for cells expressing NT receptors.
Horacio Uri Saragovi, Horacio Uri Saragovi, Horacio Uri Saragovi, Alba Galan, Alba Galan, Leonard A. Levin, Leonard A. Levin, Leonard A. Levin   +7 more
doaj   +1 more source

Epidermal growth factor receptor (EGFR) gene alteration and protein overexpression in Malaysian triple-negative breast cancer (TNBC) cohort [PDF]

, 2019
Background: Epidermal growth factor receptor (EGFR) is a member of the ErbB family of tyrosine kinase receptor proteins that plays important roles in tumour cell survival and proliferation.
Abdul Raub, Sayyidi Hamzi, Azhari, Azlah Kamilah, Eswaran, Jeyanthy, Soundararajan, Meera, Syed Husain, Sharifah Noor Akmal, Wan Hasan, Wan Atiqah Najiah, Zakaria, Zubaidah, Zulkifle, Muhamad Farid   +7 more
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Cross-sectional time series models for identifying the most important factors of e-government growth in Arab countries

Iraqi Journal for Computers and Informatics
The goal of this study was to determine the key elements driving the expansion of e-government in Arab nations. One of the econometric models—the cross-sectional time series model (panel)—was employed to accomplish the intended outcome.
Ban Qasim Al nidawy
doaj   +1 more source

In Vitro Characterization of Hypoxia Preconditioned Serum (HPS)—Fibrin Hydrogels: Basis for an Injectable Biomimetic Tissue Regeneration Therapy

Journal of Functional Biomaterials, 2019
Blood-derived growth factor preparations have long been employed to improve perfusion and aid tissue repair. Among these, platelet-rich plasma (PRP)-based therapies have seen the widest application, albeit with mixed clinical results to date.
Ektoras Hadjipanayi, Philipp Moog, Sanjar Bekeran, Katharina Kirchhoff, Andrei Berezhnoi, Juan Aguirre, Anna-Theresa Bauer, Haydar Kükrek, Daniel Schmauss, Ursula Hopfner, Sarah Isenburg, Vasilis Ntziachristos, Milomir Ninkovic, Hans-Günther Machens, Arndt F. Schilling, Ulf Dornseifer   +15 more
doaj   +1 more source

Density pertubation of unparticle dark matter in the flat Universe

, 2009
The unparticle has been suggested as a candidate of dark matter. We investigated the growth rate of the density perturbation for the unparticle dark matter in the flat Universe. First, we consider the model in which unparticle is the sole dark matter and
A. Kiakotou, A.G. Riess, A.L.B. Ribeiro, C. Di Porto, C.X. Zhang, D. Huterer, D. Polarski, E. Bertschinger, E.W. Kolb, G. Ballesteros, H. Davoudiasl, H. Georgi, H. Georgi, H. Wei, I. Laszlo, J.H. He, J.L. Feng, J.R. Mureika, Jiliang Jing, K.M. Cheung, L. Knox, L. Wang, M. Ishak, M. Kunz, M. Sereno, M.C. Kumar, N. Fornengo, P. Bernardis de, P.J.E. Peebles, P.J.E. Peebles, R. Gannouji, S. Daniel, S. Nesseris, S. Perlmutter, S. Perlmutter, S. Weinberg, S. Weinberg, S.L. Chen, Songbai Chen, T. Kikuchi, T. Padmanabhan, V. Acquaviva, V. Sahni, X.G. He, X.G. He, Xiangyun Fu, Y. Gong, Y. Wang, Y.G. Gong, Y.G. Gong   +49 more
core   +1 more source