Results 11 to 20 of about 2,830,094 (317)

A comprehensive analysis of prefoldins and their implication in cancer

iScience, 2021
Summary: Prefoldins (PFDNs) are evolutionary conserved co-chaperones, initially discovered in archaea but universally present in eukaryotes. PFDNs are prevalently organized into hetero-hexameric complexes.
Irene Herranz-Montoya, Solip Park, Nabil Djouder   +2 more
doaj   +1 more source

The Reciprocal Causation of the ASK1-JNK1/2 Pathway and Endoplasmic Reticulum Stress in Diabetes-Induced Cognitive Decline

Frontiers in Cell and Developmental Biology, 2020
Diabetes significantly induces cognitive dysfunction. Neuronal apoptosis is the main cause of diabetes-induced cognitive decline (DICD). Apoptosis signal-regulating kinase 1 (ASK1) and endoplasmic reticulum (ER) stress are remarkably activated by ...
Yanqing Wu, Yanqing Wu, Yuan Yuan, Chengbiao Wu, Ting Jiang, Beini Wang, Jun Xiong, Peipei Zheng, Yiyang Li, Jingyu Xu, Ke Xu, Yaqian Liu, Xiaokun Li, Jian Xiao   +13 more
doaj   +1 more source

Modified poloxamer 407 and hyaluronic acid thermosensitive hydrogel-encapsulated keratinocyte growth factor 2 improves knee osteoarthritis in rats

Materials & Design, 2021
Osteoarthritis (OA) is one of the most common chronic diseases, causing degenerative changes in articular cartilage and subchondral bones. To date, there is no effective drug to delay the progression of OA in clinical practice.
Rongshuai Yang, Min Chen, Xuanxin Yang, Wenzhe Sun, Chao Lu, Qi Hui, Changcan Shi, Xiaokun Li, Xiaojie Wang   +8 more
doaj   +1 more source

Detection of chromosome instability by interphase FISH in mouse and human tissues

STAR Protocols, 2021
Summary: Chromosomal instability (CIN), a type of genomic instability, favors changes in chromosome number and structure and it is associated with the progression and initiation of multiple diseases, including cancer.
Raul Torres-Ruiz, Tatiana P. Grazioso, Marta Brandt, Marta Martinez-Lage, Sandra Rodriguez-Perales, Nabil Djouder   +5 more
doaj   +1 more source

Diet, Microbiota, and Colorectal Cancer

iScience, 2019
The intestinal epithelium is a very dynamic tissue under a high regenerative pressure, which makes it susceptible to malignant transformation. Proper integration of various cell signaling pathways and a balanced cross talk between different cell types ...
Tatiana P. Grazioso, Marta Brandt, Nabil Djouder   +2 more
doaj   +1 more source

The forgotten art of cold therapeutic properties in cancer: A comprehensive historical guideGlossary

iScience, 2023
Summary: Cold therapy has been used for centuries, from Julius Caesar to Mohandas Gandhi, as a potent therapeutic approach. However, it has been largely forgotten in modern medicine.
Tatiana P. Grazioso, Nabil Djouder
doaj   +1 more source

Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

Cell Reports Medicine, 2020
Summary: Enteroviruses are suspected to contribute to insulin-producing β cell loss and hyperglycemia-induced diabetes. However, mechanisms are not fully defined.
Hugo Bernard, Ana Teijeiro, Almudena Chaves-Pérez, Cristian Perna, Basanthi Satish, Anna Novials, Jennifer P. Wang, Nabil Djouder   +7 more
doaj   +1 more source

Large-Scale Preparation of Highly Stable Recombinant Human Acidic Fibroblast Growth Factor in Escherichia coli BL21(DE3) plysS Strain

Frontiers in Bioengineering and Biotechnology, 2021
In this study, the optimum human aFGF gene encoding haFGF135 was cloned in pET3c and transferred to Escherichia coli BL21(DE3) plysS. To enhance the yield of fermentation and the expression level of the target protein, the fermentation parameters ...
Bingjie Yu, Bingjie Yu, Wenzhe Sun, Zhen Huang, Gang Sun, Le Li, Jiawei Gu, Mengying Zheng, Xiaokun Li, Xiaokun Li, ChangJu Chun, Qi Hui, Qi Hui, Xiaojie Wang, Xiaojie Wang   +14 more
doaj   +1 more source

[14C]-Tryptophan Metabolic Tracing in Liver Cancer Cells

Bio-Protocol, 2015
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for many NAD+-consuming proteins with diverse biological functions. Oscillations in NAD+ levels may influence several cellular signaling pathways.
Krishna Tummala, Nabil Djouder
doaj   +1 more source

Myocardial protection by heparin-based coacervate of FGF10

Bioactive Materials, 2021
Heart disease is still the leading killer all around the world, and its incidence is expected to increase over the next decade. Previous reports have already shown the role of fibroblast growth factor10 (FGF10) in alleviating heart diseases.
Zhouguang Wang, Yan Huang, Yan He, Sinan Khor, Xingxing Zhong, Jian Xiao, Qingsong Ye, Xiaokun Li   +7 more
doaj   +1 more source