Results 31 to 40 of about 26,786,639 (354)

Dietary Restriction, Growth Factors and Aging: from yeast to humans

Science, 2010
Eat Less, Live Long Studies in several model organisms have shown that dietary restriction without malnutrition, or manipulation of nutrient-sensing pathways through mutations or drugs, can increase life span and reduce age-related disease. Fontana et al.
L. Fontana, L. Partridge, V. Longo
semanticscholar   +1 more source

PPARγ Mediates the Anti-Epithelial-Mesenchymal Transition Effects of FGF1ΔHBS in Chronic Kidney Diseases via Inhibition of TGF-β1/SMAD3 Signaling

Frontiers in Pharmacology, 2021
Podocytes are essential components of the glomerular basement membrane. Epithelial-mesenchymal-transition (EMT) in podocytes results in proteinuria. Fibroblast growth factor 1 (FGF1) protects renal function against diabetic nephropathy (DN).
Dezhong Wang, Dezhong Wang, Tianyang Zhao, Yushuo Zhao, Yuan Yin, Yuli Huang, Zizhao Cheng, Beibei Wang, Sidan Liu, Minling Pan, Difei Sun, Zengshou Wang, Guanghui Zhu, Guanghui Zhu   +13 more
doaj   +1 more source

Role of platelet-derived growth factors in physiology and medicine.

Genes & Development, 2008
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as prototypes for growth factor and receptor tyrosine kinase function for more than 25 years. Studies of PDGFs and PDGFRs in animal development have revealed roles for PDGFR-
Johanna Andrae, R. Gallini, C. Betsholtz
semanticscholar   +1 more source

Toxicokinetics of recombinant human fibroblast growth factor 21 for injection in cynomolgus monkey for 3 months

Frontiers in Pharmacology, 2023
Introduction: Recombinant human fibroblast growth factor 21 (FGF-21) is a potential therapeutic agent for multiple metabolic diseases. However, little is known about the toxicokinetic characteristics of FGF-21.Methods: In the present study, we ...
Chao Lu, Chao Lu, Chao Lu, Lei Jin, Lei Jin, Jianing Bi, Hongyi Jin, Xinyi You, Lulu Peng, Haibing Fan, Huan Wang, Liangshun Wang, Zhengkai Fan, Xiaojie Wang, Xiaojie Wang, Xiaojie Wang, Baohua Liu, Baohua Liu   +17 more
doaj   +1 more source

IL-17A produced by POMC neurons regulates diet-induced obesity

iScience
Summary: Overeating leads to obesity, a low-grade inflammatory condition involving interleukin-17A (IL-17A). While pro-opiomelanocortin (POMC) neurons regulate feeding, their connection with IL-17A is not well understood.
Rosa Gallo, Ana Teijeiro, Mariana Angulo-Aguado, Nabil Djouder   +3 more
doaj   +1 more source

Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells

Cell Reports, 2017
Summary: Hepatocellular carcinoma (HCC) is an aggressive primary liver cancer. However, its origin remains a debated question. Using human data and various hepatocarcinogenesis mouse models, we show that, in early stages, transformed hepatocytes ...
Krishna S. Tummala, Marta Brandt, Ana Teijeiro, Osvaldo Graña, Robert F. Schwabe, Cristian Perna, Nabil Djouder   +6 more
doaj   +1 more source

FGF21 Attenuated LPS-Induced Depressive-Like Behavior via Inhibiting the Inflammatory Pathway

Frontiers in Pharmacology, 2020
Major depressive disorder is a serious neuropsychiatric disorder with high rates of recurrence and mortality. Many studies have supported that inflammatory processes play a central role in the etiology of depression.
Xue Wang, Xue Wang, Liyun Zhu, Jian Hu, Ruili Guo, Shasha Ye, Fei Liu, Dongxue Wang, Yeli Zhao, Yeli Zhao, Aiping Hu, Xiaojie Wang, Xiaojie Wang, Kaiming Guo, Li Lin, Li Lin   +15 more
doaj   +1 more source

Increased serum fibroblast growth factor 21 levels are associated with adverse clinical outcomes after intracerebral hemorrhage

Frontiers in Neuroscience, 2023
IntroductionIntracerebral hemorrhage (ICH) is the most prevalent cause of death. We sought to explore whether serum Fibroblast growth factor 21 (FGF21) is of substantial benefit in predicting poor prognosis in ICH patient.MethodsA prospective ...
Keyang Chen, Keyang Chen, Keyang Chen, Wenting Huang, Jing Wang, Huiqin Xu, Lixin Ruan, Yongang Li, Zhen Wang, Xue Wang, Li Lin, Li Lin, Xiaokun Li, Xiaokun Li, Xiaokun Li   +14 more
doaj   +1 more source

Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer [PDF]

, 2015
The extensive intratumor heterogeneity revealed by sequencing cancer genomes is an essential determinant of tumor progression, diagnosis, and treatment.
Daniela A. Ferraro, Dexter, Gerhard Christofori, Jourdan, Karey, Lamm, Marco Archetti   +6 more
core   +1 more source

Growth factors, matrices, and forces combine and control stem cells

Science, 2009
Stem cell fate is influenced by a number of factors and interactions that require robust control for safe and effective regeneration of functional tissue.
D. Discher, D. Mooney, P. Zandstra
semanticscholar   +1 more source