Results 21 to 30 of about 3,184,534 (315)

Myocardial protection by heparin-based coacervate of FGF10

Bioactive Materials, 2021
Heart disease is still the leading killer all around the world, and its incidence is expected to increase over the next decade. Previous reports have already shown the role of fibroblast growth factor10 (FGF10) in alleviating heart diseases.
Zhouguang Wang, Yan Huang, Yan He, Sinan Khor, Xingxing Zhong, Jian Xiao, Qingsong Ye, Xiaokun Li   +7 more
doaj   +1 more source

Growth Factor Regulation of Growth Factors in Articular Chondrocytes [PDF]

Journal of Biological Chemistry, 2009
Several lines of evidence indicate that polypeptide growth factors are important in articular cartilage homeostasis and repair. It is not yet clear how these growth factors are regulated. We tested the hypothesis that the growth factors responsible for regulating cartilage are themselves regulated by growth factors.
Shuiliang, Shi, Scott, Mercer, George J, Eckert, Stephen B, Trippel   +3 more
openaire   +2 more sources

Exploring the driving factors of economic growth in the world's largest economies [PDF]

, 2021
This study explores the main factors of economic growth in a panel of the world's 20 biggest economies considering the data period of 39 years (1980–2018).
Alam, Khosrul, Rahman, Mohammad Mafizur
core   +1 more source

PPARγ Mediates the Anti-Epithelial-Mesenchymal Transition Effects of FGF1ΔHBS in Chronic Kidney Diseases via Inhibition of TGF-β1/SMAD3 Signaling

Frontiers in Pharmacology, 2021
Podocytes are essential components of the glomerular basement membrane. Epithelial-mesenchymal-transition (EMT) in podocytes results in proteinuria. Fibroblast growth factor 1 (FGF1) protects renal function against diabetic nephropathy (DN).
Dezhong Wang, Dezhong Wang, Tianyang Zhao, Yushuo Zhao, Yuan Yin, Yuli Huang, Zizhao Cheng, Beibei Wang, Sidan Liu, Minling Pan, Difei Sun, Zengshou Wang, Guanghui Zhu, Guanghui Zhu   +13 more
doaj   +1 more source

Toxicokinetics of recombinant human fibroblast growth factor 21 for injection in cynomolgus monkey for 3 months

Frontiers in Pharmacology, 2023
Introduction: Recombinant human fibroblast growth factor 21 (FGF-21) is a potential therapeutic agent for multiple metabolic diseases. However, little is known about the toxicokinetic characteristics of FGF-21.Methods: In the present study, we ...
Chao Lu, Chao Lu, Chao Lu, Lei Jin, Lei Jin, Jianing Bi, Hongyi Jin, Xinyi You, Lulu Peng, Haibing Fan, Huan Wang, Liangshun Wang, Zhengkai Fan, Xiaojie Wang, Xiaojie Wang, Xiaojie Wang, Baohua Liu, Baohua Liu   +17 more
doaj   +1 more source

Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells

Cell Reports, 2017
Summary: Hepatocellular carcinoma (HCC) is an aggressive primary liver cancer. However, its origin remains a debated question. Using human data and various hepatocarcinogenesis mouse models, we show that, in early stages, transformed hepatocytes ...
Krishna S. Tummala, Marta Brandt, Ana Teijeiro, Osvaldo Graña, Robert F. Schwabe, Cristian Perna, Nabil Djouder   +6 more
doaj   +1 more source

FGF21 Attenuated LPS-Induced Depressive-Like Behavior via Inhibiting the Inflammatory Pathway

Frontiers in Pharmacology, 2020
Major depressive disorder is a serious neuropsychiatric disorder with high rates of recurrence and mortality. Many studies have supported that inflammatory processes play a central role in the etiology of depression.
Xue Wang, Xue Wang, Liyun Zhu, Jian Hu, Ruili Guo, Shasha Ye, Fei Liu, Dongxue Wang, Yeli Zhao, Yeli Zhao, Aiping Hu, Xiaojie Wang, Xiaojie Wang, Kaiming Guo, Li Lin, Li Lin   +15 more
doaj   +1 more source

Increased serum fibroblast growth factor 21 levels are associated with adverse clinical outcomes after intracerebral hemorrhage

Frontiers in Neuroscience, 2023
IntroductionIntracerebral hemorrhage (ICH) is the most prevalent cause of death. We sought to explore whether serum Fibroblast growth factor 21 (FGF21) is of substantial benefit in predicting poor prognosis in ICH patient.MethodsA prospective ...
Keyang Chen, Keyang Chen, Keyang Chen, Wenting Huang, Jing Wang, Huiqin Xu, Lixin Ruan, Yongang Li, Zhen Wang, Xue Wang, Li Lin, Li Lin, Xiaokun Li, Xiaokun Li, Xiaokun Li   +14 more
doaj   +1 more source

Antimicrobial peptides derived from growth factors

, 2007
Growth factors, comprising diverse protein and peptide families, are involved in a multitude of developmental processes, including embryogenesis, angiogenesis, and wound healing.
Davoudi, Mina, Pasupuleti, Mukesh,, Walse, Bjorn, Pasupuleti, Mukesh, Mörgelin, Matthias,, Mörgelin, Matthias, Malmsten, Martin, Schmidtchen, Artur,, Schmidtchen, Artur, Malmsten, Martin,, Rydengård, Victoria, Davoudi, Mina,, Rydengård, Victoria,, Lund University.   +13 more
core   +1 more source

IL-17A produced by POMC neurons regulates diet-induced obesity

iScience
Summary: Overeating leads to obesity, a low-grade inflammatory condition involving interleukin-17A (IL-17A). While pro-opiomelanocortin (POMC) neurons regulate feeding, their connection with IL-17A is not well understood.
Rosa Gallo, Ana Teijeiro, Mariana Angulo-Aguado, Nabil Djouder   +3 more
doaj   +1 more source