Results 21 to 30 of about 26,786,639 (354)

Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

open access: yesCell Reports Medicine, 2020
Summary: Enteroviruses are suspected to contribute to insulin-producing β cell loss and hyperglycemia-induced diabetes. However, mechanisms are not fully defined.
Hugo Bernard   +7 more
doaj   +1 more source

Mast cells as sources of cytokines, chemokines and growth factors

open access: yesImmunological Reviews, 2018
Mast cells are hematopoietic cells that reside in virtually all vascularized tissues and that represent potential sources of a wide variety of biologically active secreted products, including diverse cytokines and growth factors. There is strong evidence
K. Mukai, M. Tsai, H. Saito, S. Galli
semanticscholar   +1 more source

mTOR Signaling in Growth, Metabolism, and Disease

open access: yesCell, 2017
The mechanistic Target of Rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs including nutrients and growth factors.
R. A. Saxton, D. Sabatini
semanticscholar   +2 more sources

[14C]-Tryptophan Metabolic Tracing in Liver Cancer Cells

open access: yesBio-Protocol, 2015
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for many NAD+-consuming proteins with diverse biological functions. Oscillations in NAD+ levels may influence several cellular signaling pathways.
Krishna Tummala, Nabil Djouder
doaj   +1 more source

Large-Scale Preparation of Highly Stable Recombinant Human Acidic Fibroblast Growth Factor in Escherichia coli BL21(DE3) plysS Strain

open access: yesFrontiers in Bioengineering and Biotechnology, 2021
In this study, the optimum human aFGF gene encoding haFGF135 was cloned in pET3c and transferred to Escherichia coli BL21(DE3) plysS. To enhance the yield of fermentation and the expression level of the target protein, the fermentation parameters ...
Bingjie Yu   +14 more
doaj   +1 more source

Trophic and neurotrophic factors in human pituitary adenomas (Review) [PDF]

open access: yes, 2017
The pituitary gland is an organ that functionally connects the hypothalamus with the peripheral organs. The pituitary gland is an important regulator of body homeostasis during development, stress, and other processes.
Agostinelli, Enzo   +11 more
core   +1 more source

Myocardial protection by heparin-based coacervate of FGF10

open access: yesBioactive Materials, 2021
Heart disease is still the leading killer all around the world, and its incidence is expected to increase over the next decade. Previous reports have already shown the role of fibroblast growth factor10 (FGF10) in alleviating heart diseases.
Zhouguang Wang   +7 more
doaj   +1 more source

Growth Factor Regulation of Growth Factors in Articular Chondrocytes [PDF]

open access: yesJournal of Biological Chemistry, 2009
Several lines of evidence indicate that polypeptide growth factors are important in articular cartilage homeostasis and repair. It is not yet clear how these growth factors are regulated. We tested the hypothesis that the growth factors responsible for regulating cartilage are themselves regulated by growth factors.
Shuiliang, Shi   +3 more
openaire   +2 more sources

Advances in surgical applications of growth factors for wound healing

open access: yesBurns & Trauma, 2019
Growth factors have recently gained clinical importance for wound management. Application of recombinant growth factors has been shown to mimic cell migration, proliferation, and differentiation in vivo, allowing for external modulation of the healing ...
Sho Yamakawa, K. Hayashida
semanticscholar   +1 more source

Porcine bone scaffolds adsorb growth factors secreted by MSCs and improve bone tissue repair [PDF]

open access: yes, 2017
An ideal tissue-engineered bone graft should have both excellent pro-osteogenesis and pro-angiogenesis properties to rapidly realize the bone regeneration in vivo . To meet this goal, in this work a porcine bone scaffold was successfully used as a Trojan
Bressan, Eriberto   +6 more
core   +2 more sources

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