Results 21 to 30 of about 2,729,589 (266)

PPARγ Mediates the Anti-Epithelial-Mesenchymal Transition Effects of FGF1ΔHBS in Chronic Kidney Diseases via Inhibition of TGF-β1/SMAD3 Signaling

Frontiers in Pharmacology, 2021
Podocytes are essential components of the glomerular basement membrane. Epithelial-mesenchymal-transition (EMT) in podocytes results in proteinuria. Fibroblast growth factor 1 (FGF1) protects renal function against diabetic nephropathy (DN).
Dezhong Wang, Dezhong Wang, Tianyang Zhao, Yushuo Zhao, Yuan Yin, Yuli Huang, Zizhao Cheng, Beibei Wang, Sidan Liu, Minling Pan, Difei Sun, Zengshou Wang, Guanghui Zhu, Guanghui Zhu   +13 more
doaj   +1 more source

Growth Factor Regulation of Growth Factors in Articular Chondrocytes [PDF]

Journal of Biological Chemistry, 2009
Several lines of evidence indicate that polypeptide growth factors are important in articular cartilage homeostasis and repair. It is not yet clear how these growth factors are regulated. We tested the hypothesis that the growth factors responsible for regulating cartilage are themselves regulated by growth factors.
Shuiliang, Shi, Scott, Mercer, George J, Eckert, Stephen B, Trippel   +3 more
openaire   +2 more sources

Toxicokinetics of recombinant human fibroblast growth factor 21 for injection in cynomolgus monkey for 3 months

Frontiers in Pharmacology, 2023
Introduction: Recombinant human fibroblast growth factor 21 (FGF-21) is a potential therapeutic agent for multiple metabolic diseases. However, little is known about the toxicokinetic characteristics of FGF-21.Methods: In the present study, we ...
Chao Lu, Chao Lu, Chao Lu, Lei Jin, Lei Jin, Jianing Bi, Hongyi Jin, Xinyi You, Lulu Peng, Haibing Fan, Huan Wang, Liangshun Wang, Zhengkai Fan, Xiaojie Wang, Xiaojie Wang, Xiaojie Wang, Baohua Liu, Baohua Liu   +17 more
doaj   +1 more source

Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells

Cell Reports, 2017
Summary: Hepatocellular carcinoma (HCC) is an aggressive primary liver cancer. However, its origin remains a debated question. Using human data and various hepatocarcinogenesis mouse models, we show that, in early stages, transformed hepatocytes ...
Krishna S. Tummala, Marta Brandt, Ana Teijeiro, Osvaldo Graña, Robert F. Schwabe, Cristian Perna, Nabil Djouder   +6 more
doaj   +1 more source

FGF21 Attenuated LPS-Induced Depressive-Like Behavior via Inhibiting the Inflammatory Pathway

Frontiers in Pharmacology, 2020
Major depressive disorder is a serious neuropsychiatric disorder with high rates of recurrence and mortality. Many studies have supported that inflammatory processes play a central role in the etiology of depression.
Xue Wang, Xue Wang, Liyun Zhu, Jian Hu, Ruili Guo, Shasha Ye, Fei Liu, Dongxue Wang, Yeli Zhao, Yeli Zhao, Aiping Hu, Xiaojie Wang, Xiaojie Wang, Kaiming Guo, Li Lin, Li Lin   +15 more
doaj   +1 more source

Increased serum fibroblast growth factor 21 levels are associated with adverse clinical outcomes after intracerebral hemorrhage

Frontiers in Neuroscience, 2023
IntroductionIntracerebral hemorrhage (ICH) is the most prevalent cause of death. We sought to explore whether serum Fibroblast growth factor 21 (FGF21) is of substantial benefit in predicting poor prognosis in ICH patient.MethodsA prospective ...
Keyang Chen, Keyang Chen, Keyang Chen, Wenting Huang, Jing Wang, Huiqin Xu, Lixin Ruan, Yongang Li, Zhen Wang, Xue Wang, Li Lin, Li Lin, Xiaokun Li, Xiaokun Li, Xiaokun Li   +14 more
doaj   +1 more source

IL-17A produced by POMC neurons regulates diet-induced obesity

iScience
Summary: Overeating leads to obesity, a low-grade inflammatory condition involving interleukin-17A (IL-17A). While pro-opiomelanocortin (POMC) neurons regulate feeding, their connection with IL-17A is not well understood.
Rosa Gallo, Ana Teijeiro, Mariana Angulo-Aguado, Nabil Djouder   +3 more
doaj   +1 more source

SIRT1 Mediates Effects of FGF21 to Ameliorate Cisplatin-Induced Acute Kidney Injury

Frontiers in Pharmacology, 2020
Acute kidney injury (AKI) is a common complication in cancer patients. Kidney function is closely related to patients’ quality of life and tumor prognosis. Cisplatin is a highly effective anti-tumor drug.
Qiongzhen Chen, Junfeng Ma, Xiaoning Yang, Qinyao Li, Zhuofeng Lin, Zhuofeng Lin, Fanghua Gong, Fanghua Gong   +7 more
doaj   +1 more source

VIP/PACAP-Based Drug Development: The ADNP/NAP-Derived Mirror Peptides SKIP and D-SKIP Exhibit Distinctive in vivo and in silico Effects

Frontiers in Cellular Neuroscience, 2020
Activity-dependent neuroprotective protein (ADNP) was discovered and first characterized in the laboratory of Prof. Illana Gozes to be regulated by vasoactive intestinal peptide (VIP), and pituitary adenylate cyclase-activating peptide (PACAP) toward ...
Shlomo Sragovich, Noy Amram, Adva Yeheskel, Illana Gozes   +3 more
doaj   +1 more source

Health‐Related Social Needs in Children With Sickle Cell Disease Are Associated With Worse Health‐Related Quality of Life

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks, Molly Sonenklar, Cerelia Donald, Cecelia Valrie, Wally Smith, India Sisler   +5 more
wiley   +1 more source