Results 21 to 30 of about 2,830,094 (317)

PPARγ Mediates the Anti-Epithelial-Mesenchymal Transition Effects of FGF1ΔHBS in Chronic Kidney Diseases via Inhibition of TGF-β1/SMAD3 Signaling

Frontiers in Pharmacology, 2021
Podocytes are essential components of the glomerular basement membrane. Epithelial-mesenchymal-transition (EMT) in podocytes results in proteinuria. Fibroblast growth factor 1 (FGF1) protects renal function against diabetic nephropathy (DN).
Dezhong Wang, Dezhong Wang, Tianyang Zhao, Yushuo Zhao, Yuan Yin, Yuli Huang, Zizhao Cheng, Beibei Wang, Sidan Liu, Minling Pan, Difei Sun, Zengshou Wang, Guanghui Zhu, Guanghui Zhu   +13 more
doaj   +1 more source

Toxicokinetics of recombinant human fibroblast growth factor 21 for injection in cynomolgus monkey for 3 months

Frontiers in Pharmacology, 2023
Introduction: Recombinant human fibroblast growth factor 21 (FGF-21) is a potential therapeutic agent for multiple metabolic diseases. However, little is known about the toxicokinetic characteristics of FGF-21.Methods: In the present study, we ...
Chao Lu, Chao Lu, Chao Lu, Lei Jin, Lei Jin, Jianing Bi, Hongyi Jin, Xinyi You, Lulu Peng, Haibing Fan, Huan Wang, Liangshun Wang, Zhengkai Fan, Xiaojie Wang, Xiaojie Wang, Xiaojie Wang, Baohua Liu, Baohua Liu   +17 more
doaj   +1 more source

BONE GROWTH FACTORS

Orthopedic Clinics of North America, 2000
Osteoblastic culture models, experimental, and clinical models have revealed that bone growth factors influence cellular activity. Growth factors including bone morphogenetic proteins, transforming growth factor beta, platelet-derived growth factor, insulin-like growth factors I and II, and acidic and basic fibroblast growth factors, are powerful tools
S N, Khan, M P, Bostrom, J M, Lane
openaire   +2 more sources

FGF21 Attenuated LPS-Induced Depressive-Like Behavior via Inhibiting the Inflammatory Pathway

Frontiers in Pharmacology, 2020
Major depressive disorder is a serious neuropsychiatric disorder with high rates of recurrence and mortality. Many studies have supported that inflammatory processes play a central role in the etiology of depression.
Xue Wang, Xue Wang, Liyun Zhu, Jian Hu, Ruili Guo, Shasha Ye, Fei Liu, Dongxue Wang, Yeli Zhao, Yeli Zhao, Aiping Hu, Xiaojie Wang, Xiaojie Wang, Kaiming Guo, Li Lin, Li Lin   +15 more
doaj   +1 more source

Increased serum fibroblast growth factor 21 levels are associated with adverse clinical outcomes after intracerebral hemorrhage

Frontiers in Neuroscience, 2023
IntroductionIntracerebral hemorrhage (ICH) is the most prevalent cause of death. We sought to explore whether serum Fibroblast growth factor 21 (FGF21) is of substantial benefit in predicting poor prognosis in ICH patient.MethodsA prospective ...
Keyang Chen, Keyang Chen, Keyang Chen, Wenting Huang, Jing Wang, Huiqin Xu, Lixin Ruan, Yongang Li, Zhen Wang, Xue Wang, Li Lin, Li Lin, Xiaokun Li, Xiaokun Li, Xiaokun Li   +14 more
doaj   +1 more source

Hematopoietic growth factors [PDF]

CA: A Cancer Journal for Clinicians, 1996
Over the past ten years, the availability of pharmacologic quantities of hematopoietic growth factors has opened many avenues of study in basic science and clinical investigation. Numerous studies performed to date have demonstrated significant benefits from the use of these cytokines.
R G, Bociek, J O, Armitage
openaire   +2 more sources

IL-17A produced by POMC neurons regulates diet-induced obesity

iScience
Summary: Overeating leads to obesity, a low-grade inflammatory condition involving interleukin-17A (IL-17A). While pro-opiomelanocortin (POMC) neurons regulate feeding, their connection with IL-17A is not well understood.
Rosa Gallo, Ana Teijeiro, Mariana Angulo-Aguado, Nabil Djouder   +3 more
doaj   +1 more source

Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells

Cell Reports, 2017
Summary: Hepatocellular carcinoma (HCC) is an aggressive primary liver cancer. However, its origin remains a debated question. Using human data and various hepatocarcinogenesis mouse models, we show that, in early stages, transformed hepatocytes ...
Krishna S. Tummala, Marta Brandt, Ana Teijeiro, Osvaldo Graña, Robert F. Schwabe, Cristian Perna, Nabil Djouder   +6 more
doaj   +1 more source

SIRT1 Mediates Effects of FGF21 to Ameliorate Cisplatin-Induced Acute Kidney Injury

Frontiers in Pharmacology, 2020
Acute kidney injury (AKI) is a common complication in cancer patients. Kidney function is closely related to patients’ quality of life and tumor prognosis. Cisplatin is a highly effective anti-tumor drug.
Qiongzhen Chen, Junfeng Ma, Xiaoning Yang, Qinyao Li, Zhuofeng Lin, Zhuofeng Lin, Fanghua Gong, Fanghua Gong   +7 more
doaj   +1 more source

Neovascular growth factors [PDF]

Eye, 1991
Neovascularisation is the biological process of forming new blood vessels. Many conditions can initiate neovascularisation including trauma or chronic ischaemia produced by diseases such as diabetes. Neovascularisation proceeds through a series of steps beginning with destruction of the basement membrane surrounding the microvascular endothelial cells,
G S, Schultz, M B, Grant
openaire   +2 more sources