Results 31 to 40 of about 7,309,384 (308)

Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells

open access: yesCell Reports, 2017
Summary: Hepatocellular carcinoma (HCC) is an aggressive primary liver cancer. However, its origin remains a debated question. Using human data and various hepatocarcinogenesis mouse models, we show that, in early stages, transformed hepatocytes ...
Krishna S. Tummala   +6 more
doaj   +1 more source

SIRT1 Mediates Effects of FGF21 to Ameliorate Cisplatin-Induced Acute Kidney Injury

open access: yesFrontiers in Pharmacology, 2020
Acute kidney injury (AKI) is a common complication in cancer patients. Kidney function is closely related to patients’ quality of life and tumor prognosis. Cisplatin is a highly effective anti-tumor drug.
Qiongzhen Chen   +7 more
doaj   +1 more source

Neovascular growth factors [PDF]

open access: yesEye, 1991
Neovascularisation is the biological process of forming new blood vessels. Many conditions can initiate neovascularisation including trauma or chronic ischaemia produced by diseases such as diabetes. Neovascularisation proceeds through a series of steps beginning with destruction of the basement membrane surrounding the microvascular endothelial cells,
G S, Schultz, M B, Grant
openaire   +2 more sources

IL-17A produced by POMC neurons regulates diet-induced obesity

open access: yesiScience
Summary: Overeating leads to obesity, a low-grade inflammatory condition involving interleukin-17A (IL-17A). While pro-opiomelanocortin (POMC) neurons regulate feeding, their connection with IL-17A is not well understood.
Rosa Gallo   +3 more
doaj   +1 more source

VIP/PACAP-Based Drug Development: The ADNP/NAP-Derived Mirror Peptides SKIP and D-SKIP Exhibit Distinctive in vivo and in silico Effects

open access: yesFrontiers in Cellular Neuroscience, 2020
Activity-dependent neuroprotective protein (ADNP) was discovered and first characterized in the laboratory of Prof. Illana Gozes to be regulated by vasoactive intestinal peptide (VIP), and pituitary adenylate cyclase-activating peptide (PACAP) toward ...
Shlomo Sragovich   +3 more
doaj   +1 more source

Epidermal Growth Factor

open access: yesAnnual Review of Biochemistry, 1979
During the course of purifying nerve growth factor from the submaxillary gland of the mouse, Cohen (1960) and Levi-Montalcini and Cohen (1960) noticed that daily injections of certain gland extract fractions into newborn mice produced developmental changes that could not be ascribed to nerve growth factor.
G, Carpenter, S, Cohen
openaire   +3 more sources

Beyond Metropolitan Startup Rates: Regional Factors Associated with Startup Growth [PDF]

open access: yes, 2014
Understanding what fosters -- and hinders -- firm formation and growth at the metropolitan level across the United States is a challenge. Entrepreneurship can be measured by a variety of indicators, and they each can tell somewhat different stories ...
Jordan Bell-Masterson, Yasuyuki Motoyama
core   +1 more source

Treatment Decision‐Making Roles and Preferences Among Adolescents and Young Adults With Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Decision‐making (DM) dynamics between adolescents and young adults (AYAs) with cancer, parents, and oncologists remain underexplored in diverse populations. We examined cancer treatment DM preferences among an ethnically and socioeconomically diverse group of AYAs and their parents.
Amanda M. Gutierrez   +14 more
wiley   +1 more source

The Factors Affecting Growth and Development of Toddler (Age 1-3 Years) with History of Low Birth Weight Infant [PDF]

open access: yes, 2014
Background : Low birth weight (LBW) babies would have growth and development disorder in his life. Growth and development in toddler age (1-3 years) are influenced by various factors. This study aims to determine the relationship between sex, nutritional
Girsang, B. M. (Bina)   +2 more
core  

Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano   +7 more
wiley   +1 more source

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