Results 101 to 110 of about 6,173,170 (321)
Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis
Advanced Science, EarlyView.A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa +5 more
wiley +1 more source
Advanced Science, EarlyView.scTIDE identifies single‐cell tipping points by combining manifold‐based graph representations with optimal‐transport conditional flow matching, which preserves intrinsic topology and models distributional dynamics. It supports critical‐transition detection at individual‐cell resolution, prediction of unseen cells, and dimensionality reduction and ...
Jiayuan Zhong +6 more
wiley +1 more source
Maternal nutrient metabolism in the liver during pregnancy
Frontiers in EndocrinologyThe liver plays pivotal roles in nutrient metabolism, and correct hepatic adaptations are required in maternal nutrient metabolism during pregnancy.
Hongxu Fang +5 more
doaj +1 more source
GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines [PDF]
, 2011 Breakthrough Breast CancerBackground: Gonadotrophin releasing hormone (GnRH) analogs lower estrogen levels in pre-menopausal breast cancer patients. GnRH receptor (GnRH-R) activation also directly inhibits the growth of certain cells.
Sims Andrew H +27 more
core +2 more sources
Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia
Advanced Science, EarlyView.Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li +8 more
wiley +1 more source
Advanced Science, EarlyView.This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan +12 more
wiley +1 more source
PLoS ONE, 2017 ObjectiveUse of growth hormone is associated with side effects, including insulin resistance. The objective of this study was to determine whether tesamorelin, a stabilized growth hormone-releasing hormone analogue, would alter insulin sensitivity or ...
David R Clemmons +2 more
doaj +1 more source
Advanced Science, EarlyView.Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl +20 more
wiley +1 more source
Growth hormone : basic and clinical aspects /
, 1987 Proceedings of the 1st Nordisk insulin symposium Growth hormone: basic and clinical aspects Stockholm, Sweden, 29 June-1 July ...
Nordisk insulin symposium Growth hormone: basic and clinical aspects1st29 June-1 Juli 1987Stockholm, Sweden +1 more
core
The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction. [PDF]
, 2012 Ghrelin acylation by ghrelin O-acyltransferase (GOAT) has recently been reported to be essential for the prevention of hypoglycemia during prolonged negative energy balance.
Bidlingmaier, Martin +104 more
core +2 more sources