Results 1 to 10 of about 324,189 (163)
Growth hormone receptor gene disruption. [PDF]
Vitam Horm, 2023 Much of our understanding of growth hormone's (GH)'s numerous activities stems from studies utilizing GH receptor (GHR) knockout mice. More recently, the role of GH action has been examined by creating mice with tissue-specific or temporal GHR disruption. To date, 37 distinct GHR knockout mouse lines have been created.
List EO +6 more
europepmc +3 more sources
Jak2 is a negative regulator of ubiquitin-dependent endocytosis of the growth hormone receptor. [PDF]
PLoS ONE, 2011 Length and intensity of signal transduction via cytokine receptors is precisely regulated. Degradation of certain cytokine receptors is mediated by the ubiquitin ligase SCF(βTrCP).
Joyce Putters +5 more
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Frontiers in Veterinary Science, 2022 In previous studies, triiodothyronine (T3) was found to be lower in cows with ketosis and an effect of T3 on Growth Hormone Receptor (GHR) expression is described, e. g., in a human hepatoma cell line.
Vera Stiensmeier, Marion Schmicke
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Growth Hormone Receptor Antagonists [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2004 Pegvisomant is the only member of a new class of drugs that was especially designed to block the GH receptor (GHR) and, therefore, GH action. In this review we will describe the structure and function of GH and its receptor with specific relevance to the discovery and development of GHR antagonists.
Müller, A.F. +3 more
openaire +2 more sources
Porcine growth hormone induces the nuclear localization of porcine growth hormone receptor [PDF]
Asian-Australasian Journal of Animal Sciences, 2018 Objective Recent studies have challenged the traditional paradigm that growth hormone receptor (GHR) displays physiological functions only in the cell membrane.
Hainan Lan +4 more
doaj +1 more source
Effects of zearalenone on ovarian development of prepubertal gilts through growth hormone axis
Frontiers in Veterinary Science, 2022 This experiment aimed to establish the effects of zearalenone (ZEN) on ovarian development in prepubertal gilts through the growth hormone axis [growth hormone-releasing hormone (GHRH) / growth hormone (GH) / growth hormone receptor (GHR)].
Fengyang Wu +8 more
doaj +1 more source
Journal of Medical Case Reports, 2021 Background Adjuvant endocrine therapy is recommended for the treatment of hormone-receptor-positive breast cancer. Aromatase inhibitors are associated with significant musculoskeletal adverse effects, likely through growth hormone/insulin-like growth ...
Sasan Mirfakhraee +3 more
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Neural Regeneration Research, 2022 Both inflammation and anti-inflammation are involved in the protection of retinal cells. Antagonists of the hypothalamic growth hormone-releasing hormone receptor (GHRHR) have been shown to possess potent anti-inflammatory properties in experimental ...
Ling-Ping Cen +3 more
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IDENTIFICATION OF GH|ALUI AND GHR|ALUI GENES POLYMORPHISMS IN INDONESIAN BUFFALO
Journal of the Indonesian Tropical Animal Agriculture, 2014 Growth hormone (GH) is an anabolic hormone which sintesized and secreted by somatrotop cell inpituitary anterior lobe. GH exert its effect on growth and metabolism by interacting with a specificreceptor on the surface of the target cells.
E. Andreas +4 more
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Growth hormone, growth hormone receptor and insulin-like growth factor serum levels in patients with obesity and food addiction [PDF]
The Ukrainian Biochemical Journal, 2021 Obesity is a public health problem that increasingly becomes widespread and causes various complications. Food addiction is a hedonic eating behavior characterized by overconsumption of palatable foods (i.e., foods involve a high amount of salt, sugar ...
O. Avsar, S. Sancak, I. Koroglu, E. Avci
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