Results 41 to 50 of about 6,616,948 (200)

Compound heterozygosity for two GHR missense mutations in a patient affected by Laron Syndrome: a case report

Italian Journal of Pediatrics, 2017
Background Mutations localized in the Growth Hormone Receptor (GHR) gene are often associated with the pathogenesis of Laron Syndrome, an autosomal recessive hereditary disorder characterized by severe growth retardation.
Stefania Moia, Daniele Tessaris, Silvia Einaudi, Luisa de Sanctis, Gianni Bona, Simonetta Bellone, Flavia Prodam   +6 more
doaj   +1 more source

The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects

Frontiers in Endocrinology, 2018
The growth hormone receptor (GHR), although most well known for regulating growth, has many other important biological functions including regulating metabolism and controlling physiological processes related to the hepatobiliary, cardiovascular, renal ...
Farhad Dehkhoda, Christine M. M. Lee, Johan Medina, Andrew J. Brooks   +3 more
doaj   +1 more source

Producción de la proteína recombinante JAK2 de ratón

Biomédica: revista del Instituto Nacional de Salud, 2000
El presente trabajo describe la producción de la proteina recombinante JAK2, empleando un sistema de vectores de expresión baculovirales. La infección de células Sf9, derivadas del tejido de ovario de Spodoptera frugiperda, permitió establecer las ...
Ruth E. Garzón, Amílcar Flores, Cecilia Anzola, Myriam Sánchez de Gómez   +3 more
doaj   +1 more source

Impact of single nucleotide polymorphisms in leptin, leptin receptor, growth hormone receptor, and diacylglycerol acyltransferase (DGAT1) gene loci on milk production, feed, and body energy traits of UK dairy cows [PDF]

, 2008
The impact of 9 single nucleotide polymorphisms (SNP) in the leptin (LEP), leptin receptor (LEPR), growth hormone receptor (GHR), and diacylglycerol acyltransferase (DGAT1) gene loci on daily milk production, feed intake, and feed conversion, and weekly ...
Woodward, B. W., Forbes, A. B., Coffey, M. P., Banos, G., Woolliams, J. A.   +4 more
core   +1 more source

Exploring the growth hormone and growth hormone receptor gene families in rainbow trout (Oncorhynchus mykiss): A genome-wide perspective

In Silico Research in Biomedicine
The growth hormone (GH) and growth hormone receptor (GHR) system is a central regulator of growth and metabolism in vertebrates, with critical implications for aquaculture productivity and functional genomics research.
Neethi Ajith, Urwah Farooq, Tabinda Waheed, Suvadip Ghara, Somasundaram Iyyappan, Irfan Ahmad Bhat, Irfan Ahmad Khan, Mohd Ashraf Rather   +7 more
doaj   +1 more source

Structure and Physiological Actions of Ghrelin

Scientifica, 2013
Ghrelin is a gastric peptide hormone, discovered as being the endogenous ligand of growth hormone secretagogue receptor. Ghrelin is a 28 amino acid peptide presenting a unique n-octanoylation modification on its serine in position 3, catalyzed by ghrelin
Christine Delporte
doaj   +1 more source

Identification of Two Types of Growth Hormone Receptor Mutations in Two Strains of Sex-linked Dwarf Chickens

The Journal of Poultry Science, 2009
Sex-linked dwarf (SLD) of White Leghorn (WL; S23MA line, Okazaki station, Japan) and White Plymouth Rock (WPR; 15 line, Hyogo station, Japan) strains were established from the MA line (WL) and 16 line (WPR) of a normal growing line, respectively ...
Kenichi Tahara, Akira Tsukada, Takanobu Hanai, Kenta Okumura, Kikumi Yamada, Atsushi Murai, Rikiya Yamamoto, Makoto Maeno, Noboru Saito, Kiyoshi Shimada   +9 more
doaj   +1 more source

New and emerging treatments for estrogen receptor-positive breast cancer: focus on everolimus

Therapeutics and Clinical Risk Management, 2013
Elisavet Paplomata, Ruth O’ReganDepartment of Hematology and Medical Oncology, Winship Institute of Emory University, Atlanta, GA, USAAbstract: Management of patients with metastatic hormone receptor-positive breast cancer poses a challenge due
Paplomata E, O'Regan R
doaj  

Signal Transduction by the Growth Hormone Receptor

Experimental Biology and Medicine, 1994
It has been proposed that dimerization of identical receptor subunits by growth hormone (GH) is the mechanism of signal transduction across the cell membrane. We present here data with analogs of porcine GH (pGH), with GH receptors (GHR) mutated in the dimerization domain and with monoclonal antibodies to the GHR which indicate that dimerization is ...
Waters, M. J., Rowlinson, S. W., Clarkson, R. W., Chen, C. -M., Lobie, P. E., Norstedt, G., Mertani, H., Morel, G.,, Brinkworth, R., Wells, C. A., Bastiras, S., Robins, A. R., Muscat, G. E., Barnard, R. T.   +13 more
openaire   +4 more sources

VMN growth hormone-releasing hormone receptor regulation of counterregulatory transmission

Academia Biology
Ventromedial hypothalamic nucleus (VMN) growth hormone-releasing hormone (Ghrh) neurotransmission governs counterregulatory hormone release.
Subash Sapkota, Rami Shrestha, Sushma Katakam, Sagor C. Roy, Karen P. Briski   +4 more
doaj   +1 more source