Results 51 to 60 of about 6,616,948 (200)
pS6K1 as an efficacy marker of GnRH agonist with premenopausal breast cancer
Endocrine Connections, 2019 Estradiol is a key factor for tumorigenesis and prognosis of hormone receptor-positive breast cancer. Adipocytes are one source of estradiol in patients with breast cancer. Recent studies have shown that phosphorylated ribosomal protein S6 kinase-1 plays
Chan Sub Park +8 more
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The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438 [PDF]
, 2007 Long-term use of glucocorticoids (GC) can cause growth retardation in children due to their actions on growth plate chondrocytes. AL-438, a non-steroidal anti-inflammatory agent that acts through the glucocorticoid receptor (GR) retains full anti ...
Farquharson, C +7 more
core +1 more source
Growth Hormone Overexpression Disrupts Reproductive Status Through Actions on Leptin
Frontiers in Endocrinology, 2018 Growth and reproduction are closely related. Growth hormone (GH)-transgenic common carp exhibit accelerated growth and delayed reproductive development, which provides an amenable model to study hormone cross talk between the growth and reproductive axes.
Ji Chen +10 more
doaj +1 more source
Bioscience Reports, 2012 We have investigated the interaction between GH (growth hormone) and GHR (GH receptor). We previously demonstrated that a truncated GHR that possesses a transmembrane domain but no cytoplasmic domain blocks receptor signalling.
François Guesdon +8 more
doaj +1 more source
Endocrinology Research and Practice, 2022 Growth hormone secretagogues are synthetic peptidyl and non- peptidyl molecules that possess growth hormone releasing activity. Ghrelin is an endogenous natural ligand for the growth hormone secretagogue receptor that has recently been isolated from the ...
Serdar Güler +2 more
doaj +2 more sources
How the ghrelin receptor recognizes the acyl-modified orexigenic hormone
Frontiers in Molecular NeuroscienceGhrelin, discovered in 1999 as an endogenous ligand of the growth hormone secretagogue receptor (now known as the ghrelin receptor), is a peptide hormone with diverse physiological activities, such as stimulation of growth hormone release, increased ...
Yuki Shiimura +3 more
doaj +1 more source
Primary growth hormone insensitivity (Laron syndrome) and acquired hypothyroidism: a case report
Journal of Medical Case Reports, 2011 Introduction Primary growth hormone resistance or growth hormone insensitivity syndrome, also known as Laron syndrome, is a hereditary disease caused by deletions or different types of mutations in the growth hormone receptor gene or by post-receptor ...
Corneli Ginevra +6 more
doaj +1 more source
Lapatinib in the Treatment of Hormone Receptor-Positive/ErbB2-Positive Breast Cancer [PDF]
, 2010 In women with estrogen receptor(ER)- and ErbB2(HER2)-positive breast cancer, a vicious cycle is established between ER mechanisms of action and the growth factor receptor network, leading to enhanced cell proliferation and endocrine resistance.
Bauerfeind, Ingo +2 more
core +1 more source
Growth Hormone Receptor Expression In HCV-Related Hepatocellular Carcinoma [PDF]
Minia Journal of Medical Research:Background: Hepatocellular carcinoma (HCC) is unquestionably a major obstacle in the way of health progress in Egypt, considering its high incidence and extreme fatality.
Mona Abu El-Makarem +6 more
doaj +1 more source
A study of association between genetic markers in candidate genes and reproductive traits in one generation of a commercial broiler breeder hen population [PDF]
, 2004 Markers of alleles for three physiological candidate genes for reproductive traits, growth hormone (GHR), gonadotropin-releasing hormone receptor (GNRHR) and neuropeptide Y (NPY) were assessed for the association with the total egg production, number of ...
I C Dunn +11 more
core +1 more source