Results 121 to 130 of about 324,189 (163)
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Growth hormone receptor regulation in growth hormone-deficient dwarf rats
Journal of Endocrinology, 1993ABSTRACT In the rat, many actions of GH depend upon the sexually dimorphic pattern of exposure to GH. Hepatic human GH (hGH) receptor binding differs between the sexes and is sensitive to GH deficiency, but this has mostly been studied in acutely hypophysectomized rats, which lack all pituitary hormones.
D F, Carmignac +3 more
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Growth hormone receptors in lymphocytes of growth hormone-deficient children
Archives of Biochemistry and Biophysics, 1983Human growth hormone was injected intravenously into 18 growth hormone-deficient children and growth hormone binding sites in lymphocytes were investigated. Fresh circulating lymphocytes had a low initial value for the binding of growth hormone to solubilized receptors (3.45 +/- 1.46%) but after growth hormone injection, the binding rapidly increased ...
C, Stewart +4 more
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Signaling mechanism of growth hormone-releasing hormone receptor
2023The hypothalamic peptide growth hormone-releasing hormone (GHRH) stimulates the secretion of growth hormone (GH) from the pituitary through binding and activation of the pituitary type of GHRH receptor (GHRH-R), which belongs to the family of G protein-coupled receptors with seven potential membrane-spanning domains.
Gabor, Halmos +3 more
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Truncated growth hormone receptor isoforms
Acta Paediatrica, 1999Ross RJM. Truncated growth hormone receptor isoforms. Acta Pædiatr 1999; Suppl 428: 164–6. Stockholm. ISSN 0803–5326Truncated forms of the growth hormone receptor (GHR) that lack the majority of the cytoplasmic domain have been identified in a number of human tissues. In vitro, these truncated receptors act as dominant‐negative inhibitors of the growth
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Annales d'endocrinologie, 1992
Growth hormone (GH) exerts multiple actions and GH receptors have been demonstrated in a variety of tissues. Changes in the number of hepatic GH receptors have been demonstrated in several models of growth failure in rats. Cloning of the rabbit and human liver GH receptor has shown that the receptor is a single polypeptide chain of 620 amino acids ...
M C, Postel-Vinay +5 more
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Growth hormone (GH) exerts multiple actions and GH receptors have been demonstrated in a variety of tissues. Changes in the number of hepatic GH receptors have been demonstrated in several models of growth failure in rats. Cloning of the rabbit and human liver GH receptor has shown that the receptor is a single polypeptide chain of 620 amino acids ...
M C, Postel-Vinay +5 more
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Growth Hormone-Releasing Hormone Receptor and Growth Hormone Gene Abnormalities
2016In approximately 10 % of children with isolated growth hormone deficiency, a genetic defect can be found. Traditionally, familial isolated growth hormone deficiency (IGHD) has been classified into four types, depending on the inheritance pattern. We propose to use an adapted classification which is first based on the gene defect (GHRHR or GH1).
Jan M. Wit +2 more
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Growth hormone secretagogue receptor antagonists.
Expert opinion on therapeutic patents, 2012The patent claims peptidic/nonpeptidic inhibitors of the ghrelin receptor, the growth hormone secretagogue receptor (GHSR) 1A. Among these compounds, it was disclosed that the addition in some compounds of a GlyMetAla tripeptide at the N-terminus of the ghrelin peptide agonists converts them into ghrelin receptor antagonists.
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Activation of the growth hormone receptor
Expert Review of Endocrinology & Metabolism, 2006Growth hormone (GH) is a major regulator of postnatal growth and metabolism. There are extensive clinical applications for GH or its antagonists, including treatments for dwarfism, cancer and metabolic wasting. Owing to this, there is considerable interest in the mechanisms of GH receptor (GHR) activation.
Pelekanos, Rebecca A. +1 more
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Annales d'endocrinologie, 1990
Specific binding sites for growth hormone (GH) have been found in a variety of tissues. The rabbit liver GH receptor has recently been purified, sequenced and cloned. It is a polypeptide chain of 620 aminoacids with a single transmembrane domain. The sequence of the extracellular hormone binding domain of the receptor is identical to the sequence of ...
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Specific binding sites for growth hormone (GH) have been found in a variety of tissues. The rabbit liver GH receptor has recently been purified, sequenced and cloned. It is a polypeptide chain of 620 aminoacids with a single transmembrane domain. The sequence of the extracellular hormone binding domain of the receptor is identical to the sequence of ...
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Growth Hormone Receptor in Growth
2011It has been approximately 20 years since the cloning and characterization of the human growth hormone (GH) receptor, GHR, gene. Cell-surface GHR binds circulating GH, which promotes postnatal growth by regulating the expression of insulin-like growth factor (IGF)-I.
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