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The Growth Hormone Receptor in Growth
Endocrinology and Metabolism Clinics of North America, 2007The growth hormone receptor (GHR) is a major effector of Human growth. Functional variants of the GHR include very rare loss-of-function mutations (pathology) and very common polymorphisms (physiology). Recent experimental data have clarified the mechanisms through which mutations of the GHR or Stat5 lead to growth hormone insensitivity and major ...
Pierre, Bougnères, Vincent, Goffin
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Growth Hormone Receptor Antagonists
Neuroendocrinology, 2006The currently available long-acting somatostatin analogs normalize serum growth hormone (GH) levels and insulin-like growth factor-I levels in approximately 60% of patients with acromegaly. The recently introduced GH receptor antagonist, pegvisomant, is able to normalize insulin-like growth factor-I levels in virtually all acromegalic subjects ...
van der Lely, AJ (Aart-Jan) +1 more
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