Results 151 to 160 of about 6,616,948 (200)

Growth hormone receptors in lymphocytes of growth hormone-deficient children

Archives of Biochemistry and Biophysics, 1983
Human growth hormone was injected intravenously into 18 growth hormone-deficient children and growth hormone binding sites in lymphocytes were investigated. Fresh circulating lymphocytes had a low initial value for the binding of growth hormone to solubilized receptors (3.45 +/- 1.46%) but after growth hormone injection, the binding rapidly increased ...
C, Stewart, S, Clejan, L, Fugler, T, Cheruvanky, P J, Collipp   +4 more
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The Prolactin/Growth Hormone Receptor Family

Endocrine Reviews, 1991
PRL and GH are hormones with a wide spectrum of actions. Specific receptors are widely distributed in a number of classical target organs, but other tissues that are not known targets also contain measurable binding sites or receptor mRNA. The most likely explanation is that PRL and GH cause effects that have not yet been characterized in certain ...
Kelly, P.A., Djiane, Jean, Postel-Vinay, M.C., Edery, M.   +3 more
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Growth Hormone Receptor and Binding Protein

1990
Publisher Summary The purification and cloning of the growth hormone (GH) receptor and the binding protein have contributed to our understanding of hormonally controlled growth in mammals. This chapter discusses the purification and cloning of growth hormone receptor and binding protein.
Spencer, Steven A., Leung, David W., Godowski, Paul J., Glenn Hammonds, R., Waters, Michael J., Wood, William I.   +5 more
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Mechanism of signaling by growth hormone receptor

Physiological Reviews, 1996
Growth hormone (GH) has long been known to stimulate linear growth and regulate metabolism. The cellular mechanism by which GH elicits these effects has only recently begun to be understood. This review provides an overview of a current model of GH signaling.
L S, Argetsinger, C, Carter-Su
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Growth Hormone Receptor in Growth

2011
It has been approximately 20 years since the cloning and characterization of the human growth hormone (GH) receptor, GHR, gene. Cell-surface GHR binds circulating GH, which promotes postnatal growth by regulating the expression of insulin-like growth factor (IGF)-I.
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Defects in growth hormone receptor signaling

Trends in Endocrinology & Metabolism, 2007
Severe growth failure and insulin-like growth factor (IGF) deficiency were first reported 40 years ago in patients who ultimately proved to have mutations in the gene encoding the growth hormone receptor (GHR). So far, over 250 similar patients, encompassing more than 60 different mutations of GHR, have been reported.
Ron G, Rosenfeld, Alicia, Belgorosky, Cecelia, Camacho-Hubner, M O, Savage, J M, Wit, Vivian, Hwa   +5 more
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Expression of growth hormone receptor and growth hormone in colorectal carcinoma.

Hepato-gastroenterology, 2009
The aims of this study were to determine and compare the expression of growth hormone and growth hormone receptor in primary colorectal adenocarcinoma, regional lymph node metastases and unaffected adjacent bowel wall, and to correlate the expression of growth hormone and growth hormone receptor with clinicopathologic and survival data of the patients ...
Mijić, August, Krušlin, Božo, Tomas, Davor, Jukić, Zoran   +3 more
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Molecular biology of growth hormone receptors

Trends in Endocrinology & Metabolism, 1991
Growth hormone (GH), synthesized in and secreted from the anterior pituitary lobe, has multiple effects at both the cellular and the organismal levels, including promotion of body growth, stimulation of intermediary metabolism, and transcriptional regulation of specific genes.
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[Growth hormone receptor].

Annales d'endocrinologie, 1992
Growth hormone (GH) exerts multiple actions and GH receptors have been demonstrated in a variety of tissues. Changes in the number of hepatic GH receptors have been demonstrated in several models of growth failure in rats. Cloning of the rabbit and human liver GH receptor has shown that the receptor is a single polypeptide chain of 620 amino acids ...
M C, Postel-Vinay, J, Finidori, L, Goujon, J F, Martini, M C, Delehaye Zervas, P A, Kelly   +5 more
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Truncated growth hormone receptor isoforms

Acta Paediatrica, 1999
Ross RJM. Truncated growth hormone receptor isoforms. Acta Pædiatr 1999; Suppl 428: 164–6. Stockholm. ISSN 0803–5326Truncated forms of the growth hormone receptor (GHR) that lack the majority of the cytoplasmic domain have been identified in a number of human tissues. In vitro, these truncated receptors act as dominant‐negative inhibitors of the growth
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