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Growth hormone receptor modulators
Reviews in Endocrine and Metabolic Disorders, 2008Growth hormone (GH) regulates somatic growth, substrate metabolism and body composition. Its actions are elaborated through the GH receptor (GHR). GHR signalling involves the role of at least three major pathways, STATs, MAPK, and PI3-kinase/Akt. GH receptor function can be modulated by changes to the ligand, to the receptor or by factors regulating ...
Vita, Birzniece +2 more
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Growth hormone receptor signalling
Baillière's Clinical Endocrinology and Metabolism, 1996The growth hormone (GH) receptor belongs to the superfamily of transmembrane proteins that includes the prolactin (PRL) receptor and a number of cytokine receptors. Two forms exist for the GH receptor: the membrane-bound form is a protein of 620 amino acid residues with a unique transmembrane domain; the GH-binding protein (GHBP), which is a soluble ...
M C, Postel-Vinay, P A, Kelly
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Activation of the growth hormone receptor
Expert Review of Endocrinology & Metabolism, 2006Growth hormone (GH) is a major regulator of postnatal growth and metabolism. There are extensive clinical applications for GH or its antagonists, including treatments for dwarfism, cancer and metabolic wasting. Owing to this, there is considerable interest in the mechanisms of GH receptor (GHR) activation.
Pelekanos, Rebecca A. +1 more
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The growth hormone-releasing hormone receptor
2001Publisher Summary This chapter describes growth hormone (GH) as a polypeptide secreted by the somatotroph cells of the anterior pituitary gland, is the primary stimulator of linear growth in vertebrates and is involved in the regulation of protein and fat metabolism.
V I, DeAlmeida, K E, Mayo
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Life Sciences, 1988
The receptor for rabbit liver growth hormone (GH) has recently been purified and cloned. Sequencing data demonstrates that this site represents a new class of transmembrane receptor proteins containing covalently linked ubiquitin and N-linked oligosaccharides. Homology with the human GH liver receptor is estimated to be 84%.
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The receptor for rabbit liver growth hormone (GH) has recently been purified and cloned. Sequencing data demonstrates that this site represents a new class of transmembrane receptor proteins containing covalently linked ubiquitin and N-linked oligosaccharides. Homology with the human GH liver receptor is estimated to be 84%.
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Growth Hormone Releasing Hormone Receptor
Receptors and Channels, 2002Growth hormone releasing hormone receptor (GHRH-R) is a class II G protein-coupled receptor required for normal growth hormone (GH) synthesis and release from the pituitary, and for the normal growth and proliferation of somatotrophs within the pituitary.
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Role of growth hormone and growth hormone receptor in oocyte maturation
Molecular and Cellular Endocrinology, 2002Near the completion of growth, mammalian oocytes acquire the competence to resume and complete meiosis. In vivo the preovulatory LH surge triggers the resumption of meiosis in the oocyte contained in preovulatory follicles. When immature oocytes and the surrounding cumulus cells are released from their follicular environment, resumption of meiosis is ...
Bevers, M.M., Izadyar, F.
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Growth Hormone Receptor Polymorphisms
2007Many variables influence the outcome of growth hormone (GH) therapy (GH dose and duration, height - SDS at treatment start or at puberty onset, bone age, mid parental height, growth velocity, age, etc.). Nevertheless, all these factors only partially explain the interindividual variability in response to GH in GH deficiency (GHD) and in short non-GHD ...
Fabio, Buzi +5 more
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The Human Liver Growth Hormone Receptor*
Endocrinology, 1989Human livers, obtained from donors at the time of transplant, were homogenized in 0.25 M sucrose and fractionated by differential centrifugation. The specific binding of [125I] human (h) GH to total particulate fractions from 18 livers varied from 0.4-5.1% of the total radioactivity/100 micrograms protein.
Hocquette, Jean-François +4 more
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The Growth Hormone Secretagogue Receptor
2007The neuroendocrine hormone ghrelin, a recently discovered acylated peptide with numerous activities in various organ systems, exerts most of its known effects on the body through a highly conserved G-protein-coupled receptor, the growth hormone secretagogue receptor (GHSR) type 1a.
Conrad Russell Young, Cruz, Roy G, Smith
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