Results 1 to 10 of about 10,555 (248)

Hormone and Metabolite Changes associated with Extended Breeding Fasts in Male Northern Elephant Seals (Mirounga Angustirostris) [PDF]

, 2012
We measured metabolic hormones and several key metabolites in breeding adult male northern elephant seals to examine the regulation of fuel metabolism during extended natural fasts of over 3 months associated with high levels of energy expenditure. Males
Costa, Daniel P., Crocker, Daniel E., Houser, Dorian S., Ortiz, Rudy M., Webb, Paul M.   +4 more
core   +1 more source

The Essentiality of Amino Acids in Healthiness and Disease State: Type II Diabetes as a Case Study

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
This review investigates the functions of amino acids in normal physiological states, their potential as a diagnostic biomarker, the probable risk of deficiency, and the therapeutic ability for managing and preventing type 2 diabetes mellitus. ABSTRACT A healthy life depends on the availability and the synthesis of amino acids as they are building ...
Samuel Idowu Fayomi, Ochuko Lucky Erukainure, Nontokozo Zimbili Msomi   +2 more
wiley   +1 more source

Cisplatin‐Induced Muscle Wasting and Atrophy: Molecular Mechanism and Potential Therapeutic Interventions

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.
ABSTRACT Platinum‐based chemotherapeutics, particularly cisplatin, are crucial in the treatment of various malignancies due to their strong antitumor effects. However, a significant side effect of cisplatin is muscle atrophy, which severely impairs physical strength, diminishes quality of life and complicates cancer therapy.
Ko‐Chieh Huang, Yi‐Fen Chiang, Mohamed Ali, Shih‐Min Hsia   +3 more
wiley   +1 more source

Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons [PDF]

, 2015
The growth hormone secretagogue receptor type 1a (GHSR1a) has the highest constitutive activity of any G protein coupled receptor (GPCR). GHSR1a mediates the action of the hormone ghrelin and, its activation increases transcriptional and electrical ...
Agosti, Agustina Cabral, Altier, Andrews, Andrews, Beedle, Bennett, Cabral, Cabral, Cabral, Cao, Catterall, Chuang, Chuang, Cogger, Cowley, Cui, Daniel Castrogiovanni, Diano, Eduardo Javier López Soto, Emilio Roman Mustafa, Evron, Francina Agosti, Furness, Gamper, Gandini, Heneghan, Holst, Howard, Ikeda, Jesica Raingo, Jiang, Jiang, Kammermeier, Kammermeier, Kern, Keum, Kim, Kineman, Kisilevsky, Kisilevsky, Kitano, Kurrasch, Lauckner, Lipscombe, Liu, Liu, Lopez Soto, Mani, Maria Alejandra Gandini, Mario Perelló, McGirr, Nakazato, Pantel, Paxinos, Petersen, Raingo, Raingo, Rediger, Ribeiro, Ricardo Felix, Sakata, Schaeffer, Schellekens, Shi, Silvia Rodríguez, Suh, Suh, Tong, Uchida, Valentina Martínez Damonte, Wu, Wu, Yang, Yu, Zamponi, Zigman   +76 more
core   +4 more sources

Efficacy and safety of imeglimin add‐on to DPP‐4 inhibitor therapy in Japanese patients with type 2 diabetes mellitus: An interim analysis of the randomised, double‐blind FAMILIAR trial

Diabetes, Obesity and Metabolism, Volume 27, Issue 6, Page 3212-3222, June 2025.
Abstract Aims The ongoing FAMILIAR trial aims to provide evidence for clinical decision‐making and offer a novel treatment paradigm in type 2 diabetes mellitus (T2DM) management. The interim findings of FAMILIAR through Week 24 are reported. Materials and Methods FAMILIAR is a multicentre, randomised, double‐blind study comparing the efficacy and ...
Kohei Kaku, Masashi Shimoda, Takeshi Osonoi, Masahiro Iwamoto, Hideaki Kaneto   +4 more
wiley   +1 more source

Neuroendocrine Regulation of Metabolism [PDF]

, 2016
Given the current environment in most developed countries, it is a challenge to maintain a good balance between calories consumed and calories burned, although maintenance of metabolic balance is key to good health. Therefore, understanding how metabolic
Becu Villalobos, D., Coirini, Hector, Cornejo, María Paula, Elias, C. F., Hentges, S.T., Maliqueo, M.   +5 more
core   +3 more sources

Hypotheses in light detection by vertebrate ancient opsin in the bird brain

Journal of Neuroendocrinology, Volume 37, Issue 6, June 2025.
Abstract Extra‐retinal photoreception is common across fish and avian species. In birds, the hypothalamus contains non‐visual photoreceptors that detect light and regulate multiple endocrine systems. To date, light‐dependent control of seasonal reproduction is one of the most well‐studied systems that require deep brain photoreception.
Tyler J. Stevenson, Timothy A. Liddle, Simone L. Meddle, Jonathan H. Pérez, Stuart N. Peirson, Russell G. Foster, Gaurav Majumdar   +6 more
wiley   +1 more source

Metabolomics in cardiometabolic diseases: Key biomarkers and therapeutic implications for insulin resistance and diabetes

Journal of Internal Medicine, Volume 297, Issue 6, Page 584-607, June 2025.
Abstract Cardiometabolic diseases—including Type 2 diabetes and obesity—remain leading causes of global mortality. Recent advancements in metabolomics have facilitated the identification of metabolites that are integral to the development of insulin resistance, a characteristic feature of cardiometabolic disease. Key metabolites, such as branched‐chain
David Rizo‐Roca, John D. Henderson, Juleen R. Zierath   +2 more
wiley   +1 more source

Circulating Immune and Endocrine Markers in Currently Drinking and Abstinent Individuals With Alcohol Use Disorder and Controls

Addiction Biology, Volume 30, Issue 5, May 2025.
Circulating concentrations of BDNF, GLP‐1 and IL‐8 were altered only in abstinent individuals with AUD, likely reflecting greater disease burden and comorbidities compared to current drinkers. ABSTRACT Alcohol use disorder (AUD) is associated with changes in endocrine and immune system function. This study is a secondary analysis aimed at investigating
Ryan E. Tyler, Carlotta Vizioli, Jennifer J. Barb, Mehdi Farokhnia, Lorenzo Leggio   +4 more
wiley   +1 more source

Ghrelin receptor in two species of anuran amphibian, bullfrog (Rana catesbeiana) and Japanese tree frog (Hyla japonica)

Frontiers in Endocrinology, 2011
We identified cDNA encoding a functional growth hormone secretagogue-receptor 1a (GHS-R1a, ghrelin receptor) in two species of anuran amphibian, bullfrog (Rana catesbeiana) and Japanese tree frog (Hyla japonica). Deduced receptor protein for bullfrog and
Hiroyuki eKaiya, Yasushi eKoizumi, Norifumi eKonno, Kazutoshi eYamamoto, Minoru eUchiyama, Kenji eKangawa, Mikiya eMiyazato   +6 more
doaj   +1 more source