Results 111 to 120 of about 11,206 (235)

Lemongrass (Cymbopogon citratus) Extracts Ameliorate Polycystic Ovary Syndrome in Rats by Inhibiting Follicular Atresia and Modulating Ghrelin and Leptin

Biochemistry Research International, Volume 2026, Issue 1, 2026.
Polycystic ovary syndrome (PCOS) accelerates ovarian follicular depletion through atresia. This study investigated the therapeutic potential of aqueous (AE) and hydroethanolic (HEE) extracts of Cymbopogon citratus in mitigating PCOS‐induced ovarian damage (specifically ferroptosis, apoptosis, and oxidative stress) in a rat model of PCOS.
Vanis Slauvers Akago, Marie Alfrede Mvondo, Sefirin Djiogue, Stephen Lacmata Tamekou, Nina-Sonia Messongue Mbollo, Josue Jobin Biba, Agatha Yelah Ntumnyuy, Lylie Gisèle Atsafack Mboudem, Perpetue Atsama Mbede, Christophe Mezui, Hélène Carole Edima-Durand, Jules-Roger Kuiate, Dieudonné Njamen, Yoel Klug   +13 more
wiley   +1 more source

Unacylated ghrelin modulates circulating angiogenic cell number in insulin-resistant states [PDF]

, 2017
__Background:__ Type 2 diabetes (T2D) is associated with reduced numbers and impaired function of circulating angiogenic cells (CAC) which contributes to the progression of atherosclerosis and microvascular disease.
Baldeón Rojas, L.Y. (Lucy), Delhanty, P.J.D. (Patric), Leenen, P.J.M. (Pieter), Lely, A-J. (Aart-Jan) van der, Neggers, S.J.C.M.M. (Bas), Ozcan, B. (Behiye)   +5 more
core   +1 more source

From Pathophysiology to Treatment: Contemporary Approaches to CFRD in the Pediatric and Adolescent Population

Pediatric Diabetes, Volume 2026, Issue 1, 2026.
Cystic fibrosis‐related diabetes (CFRD) is the most prevalent nonrespiratory complication of cystic fibrosis (CF), with its prominence growing as survival rates improve due to advances in CFTR modulator therapies. Its prevalence increases with age, affecting nearly 50% of patients with CF (PwCF) over 30 years old.
Dogus Vuralli, Andrea Scaramuzza
wiley   +1 more source

Ghrelin Increases Beta-Catenin Level through Protein Kinase A Activation and Regulates OPG Expression in Rat Primary Osteoblasts. [PDF]

, 2015
Ghrelin, by binding growth hormone secretagogue receptor (GHS-R), promotes osteoblast proliferation but the signaling mechanism of GHS-R on these cells remains unclear. Since canonical Wnt/β-catenin pathway is critically associated with bone homeostasis,
Casati, L, Mrak, E, Pagani, F, Rubinacci, A, Sibilia, V, Zarattini, G   +5 more
core   +4 more sources

Advances in pancreatic cancer early diagnosis, prevention, and treatment: The past, the present, and the future

CA: A Cancer Journal for Clinicians, Volume 76, Issue 1, January/February 2026.
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a dismal prognosis, largely because of late‐stage diagnosis and therapeutic resistance. PDAC incidence has been rising, with modifiable and non‐modifiable risk factors contributing to disease development.
Alessandro Mannucci, Ajay Goel
wiley   +1 more source

Calcium-sensing receptor activation increases cell-cell adhesion and ß-cell function [PDF]

, 2012
Background/Aims: The extracellular calcium-sensing receptor (CaR) is expressed in pancreatic β-cells where it is thought to facilitate cell-to-cell communication and augment insulin secretion.
Bennett, J., Hills, C. E., Liu, K.-K., Siamantouras, E., Squires, P. E., Younis, M. Y.G.   +5 more
core   +2 more sources

Characterization of a Bovine Serum Albumin‐Derived Pro‐Cognitive Peptide (bSAPP): An Orally Active Peptide Alleviates Cognitive Decline in HFD‐Fed Mice via CCK Signaling Through the Gut‐Brain Axis

The FASEB Journal, Volume 39, Issue 24, 31 December 2025.
The popularity of the Western diet has increased the prevalence of dementia in addition to aging. We found that the digest of bovine serum albumin and a peptide derived from the digest showed an oral pro‐cognitive effect in mice fed a high‐fat diet (HFD). We named the peptide bSAPP (EC50 = 0.01 mg/kg BW). The oral effect of bSAPP was modulated by CCK1R
Biyun Zhang, Mone Ando, Kohei Kawano, Yusaku Iwasaki, Kazuo Inoue, Kousaku Ohinata   +5 more
wiley   +1 more source

Overcoming Curcumin's Limitations: Synthetic Derivatives in Diabetes and Cancer Management

Applied Research, Volume 4, Issue 6, December 2025.
Synthetic curcumin derivatives overcome curcumin's poor bioavailability through structural modifications, enhancing pharmacokinetics and therapeutic efficacy. These derivatives exhibit potent antidiabetic and anticancer activities, offering promising dual‐targeted interventions for non‐communicable diseases.
Adesola Oluwaseun Adeleye, Simon Mwaringa Dena, Oluwafemi O. Oguntibeju, Salam Titinchi, Chinyerum S. Opuwari   +4 more
wiley   +1 more source

Pathophysiology of acute experimental pancreatitis: Lessons from genetically engineered animal models and new molecular approaches [PDF]

, 2005
The incidence of acute pancreatitis is growing and worldwide population-based studies report a doubling or tripling since the 1970s. 25% of acute pancreatitis are severe and associated with histological changes of necrotizing pancreatitis. There is still
Anne Barbara Tietz, Arnush M, Bhagat L, Bhatia M, Bhatia M, Bockman DE, Burkhard Göke, Claus Schäfer, Demols A, Ebert MP, Frossard JL, Gardner JD, Gerard C, Grady T, Grisham M, Gu D, Gukovskaya AS, Gukovsky I, Hahm KB, Halangk W, Halangk W, Korc M, Lee MS, Leser HG, Massague J, Meda P, Norman J, Ohnishi H, Ohnishi H, Ohnishi H, Roberts AB, Saluja A, Schafer C, Schafer C, Schmid RM, Song AM, Steinle A, Van Acker GJD, Vogelmann R   +38 more
core   +1 more source

Ghrelin receptor in two species of anuran amphibian, bullfrog (Rana catesbeiana) and Japanese tree frog (Hyla japonica)

Frontiers in Endocrinology, 2011
We identified cDNA encoding a functional growth hormone secretagogue-receptor 1a (GHS-R1a, ghrelin receptor) in two species of anuran amphibian, bullfrog (Rana catesbeiana) and Japanese tree frog (Hyla japonica). Deduced receptor protein for bullfrog and
Hiroyuki eKaiya, Yasushi eKoizumi, Norifumi eKonno, Kazutoshi eYamamoto, Minoru eUchiyama, Kenji eKangawa, Mikiya eMiyazato   +6 more
doaj   +1 more source