Results 121 to 130 of about 5,307 (166)

Mutational analysis of ghrelin and the growth hormone secretagogue receptor

, 2016
Gueorguiev, M, Lecoeur, C, Froguel, R, Grossman, AB, Korbonits, M   +4 more
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Growth hormone secretagogue receptor antagonists

Expert Opinion on Therapeutic Patents, 2012
The patent claims peptidic/nonpeptidic inhibitors of the ghrelin receptor, the growth hormone secretagogue receptor (GHSR) 1A. Among these compounds, it was disclosed that the addition in some compounds of a GlyMetAla tripeptide at the N-terminus of the ghrelin peptide agonists converts them into ghrelin receptor antagonists.
Luca Costantino
exaly   +4 more sources

Characterization of a Monoclonal Antibody Specific for the Growth Hormone Secretagogue Receptor

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2017
Ghrelin is an orexigenic peptide hormone that primarily regulates growth hormone secretion, food intake, and energy homeostasis. It has been shown to also play a role in numerous higher brain functions, such as the regulation of inflammation and cell proliferation. Ghrelin is the endogenous ligand of the growth hormone secretagogue receptor (GHSR), a G-
Ornella Marelli, Claudia Casnici
exaly   +3 more sources

Molecular characterization of chicken growth hormone secretagogue receptor gene

General and Comparative Endocrinology, 2003
Synthetic growth hormone secretagogues stimulate growth hormone secretion by binding to a specific receptor, growth hormone secretagogue receptor (GHS-R). In this study, we investigated the cDNA and the genomic structure of chicken GHS-R. Chicken GHS-R gene is composed of two exons separated by an intron.
Ichiro Yamamoto, Masaaki Wakita, Kiyoshi Shimada   +2 more
exaly   +3 more sources

Growth Hormone–Releasing Hormone and Growth Hormone Secretagogue-Receptor Ligands

Endocrine, 2001
Growth hormone-releasing hormone (GHRH) and somatostatin are the most important hypothalamic neurohormones controlling growth hormone (GH) secretion. Several neurotransmitters and neuropeptides also play an important role in the control of GH secretion, mainly acting via modulation of GHRH and somatostatin. In the past two decades, particular attention
Emanuela Arvat, Laura Gianotti, Roberta Giordano, Fabio Broglio, Mauro Maccario, Fabio Lanfranco, Giampiero Muccioli, Mauro Papotti, Andrea Graziani, Ezio Ghigo, Romano Deghenghi   +10 more
openaire   +4 more sources

The Growth Hormone Secretagogue Receptor (Ghs-R)

Current Pharmaceutical Design, 2012
The growth hormone secretagogue receptor (GHS-R) is a component of the ghrelin signaling pathway and is involved in mediating the pleiotropic effects of ghrelin. Two isoforms have been identified, but only GHS-R1a binds with acyl ghrelin and transduces its message.
LAVIANO, Alessandro, MOLFINO, ALESSIO, Serena Rianda, ROSSI FANELLI, Filippo   +3 more
openaire   +3 more sources

The Growth Hormone Secretagogue Receptor

2007
The neuroendocrine hormone ghrelin, a recently discovered acylated peptide with numerous activities in various organ systems, exerts most of its known effects on the body through a highly conserved G-protein-coupled receptor, the growth hormone secretagogue receptor (GHSR) type 1a.
Conrad Russell Young, Cruz, Roy G, Smith
openaire   +2 more sources

Growth Hormone Secretagogue Receptor Family Members and Ligands

Endocrine, 2001
We have previously reported the cloning and characterization of a new orphan G-protein-coupled receptor (GPC-R), the growth hormone secretagogue receptor (GHS-R), and shown that this receptor mediates the activity of the growth hormone-releasing peptides (GHRPs) and nonpeptide ligands such as L-692,429 and MK-0677.
R G, Smith, R, Leonard, A R, Bailey, O, Palyha, S, Feighner, C, Tan, K K, Mckee, S S, Pong, P, Griffin, A, Howard   +9 more
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Adenosine: A Partial Agonist of the Growth Hormone Secretagogue Receptor

Biochemical and Biophysical Research Communications, 2000
The growth hormone secretagogue receptor (GHS-R) is involved in the regulation of pulsatile GH release. However, until recently, natural endogenous ligands for the receptor were unknown. We fractionated porcine hypothalamic extracts and assayed fractions for activity on HEK293 cells expressing GHS-R and aequorin.
R G, Smith, P R, Griffin, Y, Xu, A G, Smith, K, Liu, J, Calacay, S D, Feighner, C, Pong, D, Leong, A, Pomés, K, Cheng, L H, Van der Ploeg, A D, Howard, J, Schaeffer, R J, Leonard   +14 more
openaire   +2 more sources

A relationship between motilin and growth hormone secretagogue receptors

Regulatory Peptides, 2012
The motilin receptor (MR) belongs to a family of Class I G protein-coupled receptors that also includes growth hormone secretagogue receptor (GHSR). Their potentially unique structure and the molecular basis of their binding and activation are not yet clear.
Hiroaki, Nunoi, Bunzo, Matsuura, Sachiko, Utsunomiya, Teruhisa, Ueda, Teruki, Miyake, Shinya, Furukawa, Teru, Kumagi, Yoshiou, Ikeda, Masanori, Abe, Yoichi, Hiasa, Morikazu, Onji   +10 more
openaire   +2 more sources