Results 131 to 140 of about 5,307 (166)

Heterogeneity of Ghrelin/Growth Hormone Secretagogue Receptors

Neuroendocrinology, 2007
Ghrelin is a gastric polypeptide displaying strong GH-releasing activity by activation of the type 1a GH secretagogue receptor (GHS-R1a) located in the hypothalamus-pituitary axis. GHS-R1a is a G-protein-coupled receptor that, upon the binding of ghrelin or synthetic peptidyl and non-peptidyl ghrelin-mimetic agents known as GHS, preferentially couples ...
Giampiero Muccioli, Alessandra Baragli, Riccarda Granata, Mauro Papotti, Ezio Ghigo   +4 more
openaire   +1 more source

Molecular Characterization of Growth Hormone Secretagogue Receptors

2000
The synthetic hexapeptide growth hormone releasing peptide 6 (GHRP-6) mediates growth hormone (GH) release from primary pituitary cells through a distinct mechanism from that controlled by growth hormone releasing hormone (GHRH) or somatostatin (1–3).
Andrew D. Howard, Scott D. Feighner, Roy G. Smith, Lex H. T. Van der Ploeg   +3 more
openaire   +1 more source

Distribution and regulation of chicken growth hormone secretagogue receptor isoforms

General and Comparative Endocrinology, 2003
Chicken ghrelin has recently been isolated as a hormone which stimulates growth hormone and corticosterone secretion in chicken. Ghrelin mediates these actions in mammals by binding to the growth hormone secretagogue receptor (GHS-R). In this study, we describe the partial cloning of two chicken GHS-R (cGHS-R) isoforms: cGHS-R1a and cGHS-R1c.
S M E, Geelissen, I M E, Beck, V M, Darras, E R, Kühn, S, Van der Geyten   +4 more
openaire   +2 more sources

Discovery and Pharmacological Evaluation of Growth Hormone Secretagogue Receptor Antagonists

Journal of Medicinal Chemistry, 2006
The discovery and pharmacological evaluation of potent, selective, and orally bioavailable growth hormone secretagogue receptor (GHS-R) antagonists are reported. Previously, 2,4-diaminopyrimidine-based GHS-R antagonists reported from our laboratories have been shown to be dihydrofolate reductase (DHFR) inhibitors.
Zhili, Xin, Michael D, Serby, Hongyu, Zhao, Christi, Kosogof, Bruce G, Szczepankiewicz, Mei, Liu, Bo, Liu, Charles W, Hutchins, Kathy A, Sarris, Ethan D, Hoff, H Douglas, Falls, Chun W, Lin, Christopher A, Ogiela, Christine A, Collins, Michael E, Brune, Eugene N, Bush, Brian A, Droz, Thomas A, Fey, Victoria E, Knourek-Segel, Robin, Shapiro, Peer B, Jacobson, David W A, Beno, Teresa M, Turner, Hing L, Sham, Gang, Liu   +24 more
openaire   +2 more sources

On the use of cells or membranes for receptor binding: Growth hormone secretagogues

Analytical Biochemistry, 2010
Receptor binding techniques have been widely used in different biochemical applications, with isolated membranes being the most used receptor preparation in this type of assays. In this study, intact cells were compared with isolated membranes as receptor support for radioligand receptor binding assay.
Pinyot, Armand, Nikolovski, Zoran, Bosch, Jaume, Segura, Jordi, Gutiérrez-Gallego, Ricardo   +4 more
openaire   +2 more sources

Thyroid Hormones Regulate Pituitary Growth Hormone Secretagogue Receptor Gene Expression

Journal of Neuroendocrinology, 2001
AbstractThyroid hormones regulate growth hormone (GH) secretion by actions both at the hypothalamus and at the pituitary gland. At the level of the pituitary, thyroid hormones increase GH and GH‐releasing hormone receptor (GHRH‐R) mRNA expression.
J, Kamegai, H, Tamura, S, Ishii, H, Sugihara, I, Wakabayashi   +4 more
openaire   +2 more sources

Analysis of polymorphism of growth hormone secretagogue receptor in goat

Indian Journal of Animal Research, 2018
Two pairs of primers (GHSR-3, GHSR-4) were used to amplify GHSR gene of Boer goat, Yaoshan goat and black goat. Totally two mutation sites (SNP loci), G200A and T628C were detected in amplification fragments of GHSR-3 and GHSR-4 respectively. For locus G200A, allele frequencies of G and A in Yaoshan goat, Boer goat and black goat were 0.637/0.595/0.827
J. Y. Bai, Y. G. Zhao, G. L. Li, Y. B. Yang, X. Wang, S. Yang   +5 more
openaire   +1 more source

Structure and regulation of the growth hormone secretagogue receptor.

Minerva endocrinologica, 2003
Synthetic growth hormone secretagogues (GHS) stimulate growth hormone release through binding to a recently cloned specific growth hormone secretagogue receptor (GHS-R). Ghrelin, the endogenous ligand of this receptor, is part of a new endocrine pathway controlling GH secretion.
openaire   +1 more source

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Hope Rugo, Laura Huppert
exaly  

Identification of a Putative β‐Arrestin Superagonist of the Growth Hormone Secretagogue Receptor (GHSR)

ChemMedChem, 2021
Hideaki Fujii, Fumika Karaki, Yasuhito Uezono   +2 more
exaly