Results 151 to 160 of about 6,273,650 (192)

The Growth Hormone Secretagogue Receptor

2007
The neuroendocrine hormone ghrelin, a recently discovered acylated peptide with numerous activities in various organ systems, exerts most of its known effects on the body through a highly conserved G-protein-coupled receptor, the growth hormone secretagogue receptor (GHSR) type 1a.
Conrad Russell Young, Cruz, Roy G, Smith
openaire   +2 more sources

Molecular characterization of chicken growth hormone secretagogue receptor gene

General and Comparative Endocrinology, 2003
Synthetic growth hormone secretagogues stimulate growth hormone secretion by binding to a specific receptor, growth hormone secretagogue receptor (GHS-R). In this study, we investigated the cDNA and the genomic structure of chicken GHS-R. Chicken GHS-R gene is composed of two exons separated by an intron.
Ichiro Yamamoto, Masaaki Wakita, Kiyoshi Shimada   +2 more
exaly   +3 more sources

Growth Hormone Secretagogue Receptor Family Members and Ligands

Endocrine, 2001
We have previously reported the cloning and characterization of a new orphan G-protein-coupled receptor (GPC-R), the growth hormone secretagogue receptor (GHS-R), and shown that this receptor mediates the activity of the growth hormone-releasing peptides (GHRPs) and nonpeptide ligands such as L-692,429 and MK-0677.
R G, Smith, R, Leonard, A R, Bailey, O, Palyha, S, Feighner, C, Tan, K K, Mckee, S S, Pong, P, Griffin, A, Howard   +9 more
openaire   +2 more sources

Adenosine: A Partial Agonist of the Growth Hormone Secretagogue Receptor

Biochemical and Biophysical Research Communications, 2000
The growth hormone secretagogue receptor (GHS-R) is involved in the regulation of pulsatile GH release. However, until recently, natural endogenous ligands for the receptor were unknown. We fractionated porcine hypothalamic extracts and assayed fractions for activity on HEK293 cells expressing GHS-R and aequorin.
R G, Smith, P R, Griffin, Y, Xu, A G, Smith, K, Liu, J, Calacay, S D, Feighner, C, Pong, D, Leong, A, Pomés, K, Cheng, L H, Van der Ploeg, A D, Howard, J, Schaeffer, R J, Leonard   +14 more
openaire   +2 more sources

Heterogeneity of Ghrelin/Growth Hormone Secretagogue Receptors

Neuroendocrinology, 2007
Ghrelin is a gastric polypeptide displaying strong GH-releasing activity by activation of the type 1a GH secretagogue receptor (GHS-R1a) located in the hypothalamus-pituitary axis. GHS-R1a is a G-protein-coupled receptor that, upon the binding of ghrelin or synthetic peptidyl and non-peptidyl ghrelin-mimetic agents known as GHS, preferentially couples ...
Giampiero Muccioli, Alessandra Baragli, Riccarda Granata, Mauro Papotti, Ezio Ghigo   +4 more
openaire   +1 more source

On the use of cells or membranes for receptor binding: Growth hormone secretagogues

Analytical Biochemistry, 2010
Receptor binding techniques have been widely used in different biochemical applications, with isolated membranes being the most used receptor preparation in this type of assays. In this study, intact cells were compared with isolated membranes as receptor support for radioligand receptor binding assay.
Jordi Segura
exaly   +3 more sources

Molecular Characterization of Growth Hormone Secretagogue Receptors

2000
The synthetic hexapeptide growth hormone releasing peptide 6 (GHRP-6) mediates growth hormone (GH) release from primary pituitary cells through a distinct mechanism from that controlled by growth hormone releasing hormone (GHRH) or somatostatin (1–3).
Andrew D. Howard, Scott D. Feighner, Roy G. Smith, Lex H. T. Van der Ploeg   +3 more
openaire   +1 more source

Discovery and Pharmacological Evaluation of Growth Hormone Secretagogue Receptor Antagonists

Journal of Medicinal Chemistry, 2006
The discovery and pharmacological evaluation of potent, selective, and orally bioavailable growth hormone secretagogue receptor (GHS-R) antagonists are reported. Previously, 2,4-diaminopyrimidine-based GHS-R antagonists reported from our laboratories have been shown to be dihydrofolate reductase (DHFR) inhibitors.
Zhili, Xin, Michael D, Serby, Hongyu, Zhao, Christi, Kosogof, Bruce G, Szczepankiewicz, Mei, Liu, Bo, Liu, Charles W, Hutchins, Kathy A, Sarris, Ethan D, Hoff, H Douglas, Falls, Chun W, Lin, Christopher A, Ogiela, Christine A, Collins, Michael E, Brune, Eugene N, Bush, Brian A, Droz, Thomas A, Fey, Victoria E, Knourek-Segel, Robin, Shapiro, Peer B, Jacobson, David W A, Beno, Teresa M, Turner, Hing L, Sham, Gang, Liu   +24 more
openaire   +2 more sources

Thyroid Hormones Regulate Pituitary Growth Hormone Secretagogue Receptor Gene Expression

Journal of Neuroendocrinology, 2001
AbstractThyroid hormones regulate growth hormone (GH) secretion by actions both at the hypothalamus and at the pituitary gland. At the level of the pituitary, thyroid hormones increase GH and GH‐releasing hormone receptor (GHRH‐R) mRNA expression.
J, Kamegai, H, Tamura, S, Ishii, H, Sugihara, I, Wakabayashi   +4 more
openaire   +2 more sources

Analysis of polymorphism of growth hormone secretagogue receptor in goat

Indian Journal of Animal Research, 2018
Two pairs of primers (GHSR-3, GHSR-4) were used to amplify GHSR gene of Boer goat, Yaoshan goat and black goat. Totally two mutation sites (SNP loci), G200A and T628C were detected in amplification fragments of GHSR-3 and GHSR-4 respectively. For locus G200A, allele frequencies of G and A in Yaoshan goat, Boer goat and black goat were 0.637/0.595/0.827
J. Y. Bai, Y. G. Zhao, G. L. Li, Y. B. Yang, X. Wang, S. Yang   +5 more
openaire   +1 more source