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Known and Unknown Growth Hormone Secretagogue Receptors and their Ligands
2004The discovery of ghrelin is a typical example of reverse pharmacology: first the synthetic analogues (i.e. peptidyl and non-peptidyl growth hormone secretagogues (GHS)); second the receptor; third the natural ligand for this orphan receptor, i.e. ghrelin. Ghrelin is providing new understanding about how the gastrointestinal tract and nutritional intake
MUCCIOLI, Giampiero +3 more
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Structure and regulation of the growth hormone secretagogue receptor.
Minerva endocrinologica, 2003Synthetic growth hormone secretagogues (GHS) stimulate growth hormone release through binding to a recently cloned specific growth hormone secretagogue receptor (GHS-R). Ghrelin, the endogenous ligand of this receptor, is part of a new endocrine pathway controlling GH secretion.
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[Molecular analysis of the human "growth hormone secretagogue"-receptor].
Medizinische Klinik (Munich, Germany : 1983), 1999Growth hormone secretagogues (GHS) are highly potent synthetic peptides which release growth hormone (GH) by activation of a growth hormone-releasing hormone-independent signal cascade. A specific growth hormone secretagogue receptor (GHS-R) has been isolated, its endogenous ligand is still unknown.
S, Petersenn +3 more
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GHSR: Growth Hormone Secretagogue Receptor
2016Yue Yin, Shiying Liu, Weizhen Zhang
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Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor
Trends in Endocrinology and Metabolism, 2001Hiroshi Hosoda +2 more
exaly