Results 31 to 40 of about 11,206 (235)

Development and Characterization of an F-labeled Ghrelin Peptidomimetic for Imaging the Cardiac Growth Hormone Secretagogue Receptor [PDF]

Molecular Imaging, 2018
One-third of patients with heart disease develop heart failure, which is diagnosed through imaging and detection of circulating biomarkers. Imaging strategies reveal morphologic and functional changes but fall short of detecting molecular abnormalities ...
Ahmed Abbas MSc, Lihai Yu PhD, Tyler Lalonde BSc, Derek Wu BSc, Jonathan D. Thiessen PhD, Leonard G. Luyt PhD, Savita Dhanvantari PhD   +6 more
doaj   +2 more sources

Pharmacokinetic and pharmacodynamic results from a randomized controlled study with the growth hormone secretagogue receptor blocker PF-5190457 in recently abstinent patients with alcohol use disorder. [PDF]

Int J Neuropsychopharmacol
Tyler RE, Pfaff RK, Khan RMN, Loften A, Zurick R, Zeng Y, Arisa OT, Harvey C, Akhlaghi F, Figg WD, Farokhnia M, Leggio L.   +11 more
europepmc   +3 more sources

Growth Hormone Secretagogue Receptor (GHSR) Is Elevated in Myocardial Tissues of DMD <i>mdx:utrn</i>^-/- Mice, and Correlates Strongly with Inflammatory Markers, and Negatively with Cardiac Function. [PDF]

Cells
Naghibosadat M, McClennan A, Egiian M, Flynn-Rizk R, Lalonde T, Charron C, Chhabra A, Luyt LG, Dhanvantari S, Hoffman LM.   +9 more
europepmc   +3 more sources

Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer's disease. [PDF]

Sci Transl Med, 2019
Tian J, Guo L, Sui S, Driskill C, Phensy A, Wang Q, Gauba E, Zigman JM, Swerdlow RH, Kroener S, Du H.   +10 more
europepmc   +3 more sources

Establishment of a Cell Line Stably Expressing the Growth Hormone Secretagogue Receptor to Identify Crocin as a Ghrelin Agonist. [PDF]

Biomolecules, 2022
Wang CH, Tseng CY, Hsu WL, Tzen JTC.
europepmc   +3 more sources

Novel isoxazole carboxamides as growth hormone secretagogue receptor (GHS-R) antagonists

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Bo Liu, Gang Liu, Zhili Xin, Micheal D. Serby, Hongyu Zhao, Verlyn G. Schaefer, Hugh D. Falls, Wiweka Kaszubska, Christine A. Collins, Hing L. Sham   +9 more
openalex   +3 more sources

Hindbrain ghrelin and liver-expressed antimicrobial peptide 2, ligands for growth hormone secretagogue receptor, bidirectionally control food intake.

Am J Physiol Regul Integr Comp Physiol, 2023
Wald HS, Ghidewon MY, Hayes MR, Grill HJ.   +3 more
europepmc   +3 more sources

Growth hormone secretagogue receptor deficiency in mice protects against obesity-induced hypertension. [PDF]

Physiol Rep, 2014
Abstract Growth hormone secretagogue receptor (GHS-R) signaling has been associated with growth hormone release, increases in food intake and pleiotropic cardiovascular effects. Recent data demonstrated that acute GHS-R antagonism leads to increases in mean arterial pressure mediated by the sympathetic nervous system in rats; a highly undesirable ...
Harris LE, Morgan DG, Balthasar N.
europepmc   +6 more sources

2,4-Diaminopyrimidine Derivatives as Potent Growth Hormone Secretagogue Receptor Antagonists

Journal of Medicinal Chemistry, 2006
Ghrelin, a gut-derived orexigenic hormone, is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R). Centrally administered ghrelin has been shown to cause hunger and increase food intake in rodents. Inhibition of ghrelin actions with ghrelin antibody, peptidyl GHS-R antagonists, and antisense oligonucleosides resulted in weight loss
Michael D. Serby, Hongyu Zhao, Bruce G. Szczepankiewicz, Christi Kosogof, Zhili Xin, Bo Liu, Mei Liu, Lissa T.J. Nelson, Wiweka Kaszubska, Hugh D. Falls, Verlyn G. Schaefer, Eugene N. Bush, Robin Shapiro, Brian A. Droz, Victoria Knourek-Segel, Thomas A. Fey, Michael E. Brune, David W. A. Beno, Theresa M. Turner, Christine A. Collins, Peer B. Jacobson, Hing L. Sham, Gang Liu   +22 more
openalex   +3 more sources

Centrally administered growth hormone secretagogue receptor antagonist DLys decreases alcohol intake and preference in male mice. [PDF]

Neuroreport
Richardson RS, Gomez JL, Vendruscolo LF, Leggio L, Ryabinin AE.   +4 more
europepmc   +3 more sources