Results 31 to 40 of about 10,555 (248)

Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity [PDF]

Journal of Clinical Investigation, 2002
Growth hormone secretagogues (GHSs) stimulate GH secretion and food intake. GHS receptor (GHS-R) mRNA has been identified mainly in the arcuate nucleus (Arc) and ventromedial nucleus of the hypothalamus and in the pituitary. Ghrelin, an endogenous ligand for GHS-R, has recently been purified from rat stomach.
Yujin Shuto, Tamotsu Shibasaki, Asuka Otagiri, Hideki Kuriyama, Hisayuki Ohata, Hideki Tamura, Jun Kamegai, Hitoshi Sugihara, Shinichi Oikawa, Ichiji Wakabayashi   +9 more
openalex   +4 more sources

Growth hormone secretagogue receptor and cannabinoid receptor type 1 intersection in the mouse brain. [PDF]

Brain Struct Funct
Abstract The growth hormone secretagogue receptor (GHSR) and the cannabinoid receptor type 1 (CB1R) are G-protein coupled receptors highly expressed in the brain and involved in critical regulatory processes, such as energy homeostasis, appetite control, reward, and stress responses.
Saenz C, Fernandez G, Llovera R, Tolosa MJ, Cantel S, Fehrentz JA, Mackie K, Leggio L, Zigman J, De Francesco PN, Perello M.   +10 more
europepmc   +4 more sources

Diversification and coevolution of the ghrelin/growth hormone secretagogue receptor system in vertebrates. [PDF]

Ecol Evol, 2016
AbstractThe gut hormone ghrelin is involved in numerous metabolic functions, such as the stimulation of growth hormone secretion, gastric motility, and food intake. Ghrelin is modified by ghrelin O‐acyltransferase (GOAT) or membrane‐bound O‐acyltransferase domain‐containing 4 (MBOAT4) enabling action through the growth hormone secretagogue receptors ...
Tine M, Kuhl H, Teske PR, Tschöp MH, Jastroch M.   +4 more
europepmc   +6 more sources

Growth Hormone Secretagogue Receptor Dimers: A New Pharmacological Target [PDF]

eNeuro, 2015
AbstractThe growth hormone secretagogue receptor (GHSR1a), the target of the ghrelin peptide, is widely distributed throughout the brain, and, while studies have often reported very low or absent levels of central ghrelin, it is now known that GHSR1a, even in the absence of a natural ligand, has physiological roles.
Wellman M, Abizaid A.
europepmc   +5 more sources

Ghrelin transport across the blood–brain barrier can occur independently of the growth hormone secretagogue receptor [PDF]

Molecular Metabolism, 2018
Objective: The blood–brain barrier (BBB) regulates the entry of substrates and peptides into the brain. Ghrelin is mainly produced in the stomach but exerts its actions in the central nervous system (CNS) by crossing the BBB.
Elizabeth M. Rhea, Therese S. Salameh, Sarah Gray, Jingjing Niu, William A. Banks, Jenny Tong   +5 more
doaj   +2 more sources

Development and Characterization of an F-labeled Ghrelin Peptidomimetic for Imaging the Cardiac Growth Hormone Secretagogue Receptor [PDF]

Molecular Imaging, 2018
One-third of patients with heart disease develop heart failure, which is diagnosed through imaging and detection of circulating biomarkers. Imaging strategies reveal morphologic and functional changes but fall short of detecting molecular abnormalities ...
Ahmed Abbas MSc, Lihai Yu PhD, Tyler Lalonde BSc, Derek Wu BSc, Jonathan D. Thiessen PhD, Leonard G. Luyt PhD, Savita Dhanvantari PhD   +6 more
doaj   +2 more sources

Growth Hormone Secretagogue Receptor (GHSR) Is Elevated in Myocardial Tissues of DMD <i>mdx:utrn</i>^-/- Mice, and Correlates Strongly with Inflammatory Markers, and Negatively with Cardiac Function. [PDF]

Cells
Naghibosadat M, McClennan A, Egiian M, Flynn-Rizk R, Lalonde T, Charron C, Chhabra A, Luyt LG, Dhanvantari S, Hoffman LM.   +9 more
europepmc   +2 more sources

Ghrelin protects the myocardium with hypoxia/reoxygenation treatment through upregulating the expression of growth hormone, growth hormone secretagogue receptor and insulin-like growth factor-1, and promoting the phosphorylation of protein kinase B. [PDF]

Int J Mol Med, 2018
Liu Y, Liu Y, Li G, Chen Z, Gu G.
europepmc   +3 more sources

Ghrelin Decreases Firing Activity of Gonadotropin-Releasing Hormone (GnRH) Neurons in an Estrous Cycle and Endocannabinoid Signaling Dependent Manner. [PDF]

, 2013
The orexigenic peptide, ghrelin is known to influence function of GnRH neurons, however, the direct effects of the hormone upon these neurons have not been explored, yet.
Farkas, Imre, Liposits, Zsolt, Sárvári, Miklós, Vastagh, Csaba   +3 more
core   +10 more sources

Ghrelin and the growth hormone secretagogue receptor in growth and development [PDF]

International Journal of Obesity, 2009
The pancreas is a major source of ghrelin in the perinatal period, whereas gastric production progressively increases after birth. Loss of function of the genes for ghrelin or for the constitutively activated growth hormone secretagogue receptor (GHSR) does not affect birth weight and early postnatal growth.
K. De Waele, Pallavi Walia, Jean-Pierre Chanoine   +2 more
openaire   +3 more sources