Neutrophil elastase (Elane) may serve as a potential therapeutic target in inflammatory bowel disease-associated growth attenuation: focus on the epiphyseal growth plate in young male rats [PDF]
Frontiers in EndocrinologyIntroductionGrowth is frequently compromised in children with inflammatory bowel disease (IBD). With the prevalence of pediatric IBD having doubled over the past 25 years, growth failure poses a major additional challenge in managing the disease. Despite
Chen Menahem +15 more
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miRNA-based regulation in growth plate cartilage: mechanisms, targets, and therapeutic potential [PDF]
Frontiers in EndocrinologyMicroRNAs (miRNAs) are critical regulators of the skeleton. In the growth plate, these small non-coding RNAs modulate gene networks that drive key stages of chondrogenesis, including proliferation, differentiation, extracellular matrix synthesis and ...
Prachi Thakore, Anne M. Delany
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A new era of genetic diagnosis for short stature children: A review [PDF]
Precision and Future Medicine, 2022 Children with short stature are often presented to pediatric endocrinologists. Short stature is defined as the height that is more than two standard deviations below the corresponding mean height for a specific age and sex in a reference population ...
Yoo-Mi Kim
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Bilateral distal femoral epiphyseal detachment in a young adult: a case report [PDF]
Journal of Trauma and Injury, 2023 Epiphyseal dislocations and fractures frequently occur in children and adolescents. However, these injuries seldom involve the distal femur, and bilateral cases are even rarer. We present an unusual case of bilateral epiphyseal detachment of the femur in
Armand Yepie +3 more
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Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review
Frontiers in Bioengineering and Biotechnology, 2021 The growth plate (GP) is a cartilaginous region situated between the epiphysis and metaphysis at the end of the immature long bone, which is susceptible to mechanical damage because of its vulnerable structure.
Xianggang Wang +17 more
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Angular Deformities of the Knee in Children Treated with Guided Growth [PDF]
Malaysian Orthopaedic Journal, 2021 INTRODUCTION: The guided growth technique is an alternative to corrective osteotomy for treating angular deformities of the extremities. It has the advantage of being minimally invasive and is effective in a growing child.
Jamil K +4 more
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Secondary ossification center induces and protects growth plate structure
eLife, 2020 Growth plate and articular cartilage constitute a single anatomical entity early in development but later separate into two distinct structures by the secondary ossification center (SOC). The reason for such separation remains unknown.
Meng Xie +31 more
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Frontiers in Endocrinology, 2023 IntroductionHistomorphometry of rodent metaphyseal trabecular bone, by histology or microCT, is generally restricted to the mature secondary spongiosa, excluding the primary spongiosa nearest the growth plate by imposing an ‘offset’.
P. L. Salmon +5 more
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Pubertal growth and epiphyseal fusion [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2015 The complex networks of nutritional, cellular, paracrine, and endocrine factors are closely related with pubertal growth and epiphyseal fusion. Important influencing factors include chondrocyte differentiation capacity, multiple molecular pathways active
Kye Shik Shim
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The Hunt Is On! In Pursuit of the Ideal Stem Cell Population for Cartilage Regeneration
Frontiers in Bioengineering and Biotechnology, 2022 Cartilage injury and degeneration are hallmarks of osteoarthritis (OA), the most common joint disease. OA is a major contributor to pain, loss of function, and reduced quality of life.
T. Mark Campbell +11 more
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