Results 41 to 50 of about 870,777 (309)

Endocrine Regulation of the Growth Plate [PDF]

Hormone Research in Paediatrics, 2005
Longitudinal bone growth occurs at the growth plate by endochondral ossification. Within the growth plate, chondrocyte proliferation, hypertrophy, and cartilage matrix secretion result in chondrogenesis. The newly formed cartilage is invaded by blood vessels and bone cells that remodel the newly formed cartilage into bone tissue.
Ola, Nilsson, Rose, Marino, Francesco, De Luca, Moshe, Phillip, Jeffrey, Baron   +4 more
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Continental growth and the crustal record

, 2013
Funding: Natural Environment Research Council (NERC) (grant NE/J021822/1) and the University of St. Andrews.The continental crust is the archive of Earth history.
Hawkesworth, Chris, Cawood, Peter, Dhuime, Bruno   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Expression patterns of chondrocyte genes cloned by differential display in tibial dyschondroplasia

, 2000
Tibial dyschondroplasia (TD) appears to involve a failure of the growth plate chondrocytes within growing long bones to differentiate fully to the hypertrophic stage, resulting in a mass of prehypertrophic chondrocytes which form the avascular TD lesion.
Farquharson, C, Lester, D, Thorp, B H, Botman, M, Farquharson, C; id_orcid, Thorp, B.H, Jefferies, D, Whitehead, C.C, Houston, B, Whitehead, C C   +9 more
core   +1 more source

The Crosstalk Between Cartilage and Bone in Skeletal Growth

Biomedicines
While the flat bones of the face, most of the cranial bones, and the clavicles are formed directly from sheets of undifferentiated mesenchymal cells, most bones in the human body are first formed as cartilage templates. Cartilage is subsequently replaced
Frank Hernández-García, Ángela Fernández-Iglesias, Julián Rodríguez Suárez, Helena Gil Peña, José M. López, Rocío Fuente Pérez   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Accelerated Growth Plate Mineralization and Foreshortened Proximal Limb Bones in Fetuin-A Knockout Mice [PDF]

, 2012
PMCID: PMC3473050This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Himadri S Gupta, Stefanie Krauss, Philip Catalá-Lehnen, Willi Jahnen-Dechent, Busse, Björn, Michael Kerschnitzki (126715), Busse, B., Peter Fratzl (126726), Jahnen-Dechent Willi, Fratzl, P., Zaslansky, Paul, Jahnen-Dechent, W., Schäfer, Caro, Jong Seto (126700), Kerschnitzki, Michael, Schäfer, Cora, Admir Masic (126713), Kerschnitzki Michael, Gupta, H., Masic, A., Björn Busse, Stefanie Krauss (126706), Paul Zaslansky (126717), Seto Jong, Himadri S. Gupta (126704), Jahnen-Dechent, Willi, Bösecke, Peter, Peter Boesecke (126719), Gupta, Himradi S., John W. C. Dunlop (126709), Admir Masic, Thorsten Schinke, Catalá-Lehnen, Philip, Catalá-Lehnen Philip, Cora Schäfer (126705), Schaefer, C, Thorsten Schinke (126724), Masic, Admir, Willi Jahnen-Dechent (126728), John W C Dunlop, Kerschnitzki, M., Michael Kerschnitzki, Schäfer, C., Krauss, Stefanie, Fratzl, P, Catala-Lehnen, P, Boesecke Peter, Dunlop, J., Gupta Himadri S., Masic, A, Peter Boesecke, Schinke, T, Peter Fratzl, Jahnen-Dechent, W, Schinke Thorsten, Catala-Lehnen, P., Paul Zaslansky, Zaslansky, P., Philip Catalá-Lehnen (126722), Boesecke, Peter, Seto, Jong, Schinke, T., Busse, B, Krauss, S, Björn Busse (126702), Seto, J, Schäfer Cora, Boesecke, P., Gupta, Himadri S., Boesecke, P, Cora Schäfer, Krauss, S., Dunlop, John W. C., Dunlop John W. C., Jong Seto, Busse Björn, Schinke, Thorsten, Masic Admir, Krauss Stefanie, Zaslansky Paul, Gupta, HS, Kerschnitzki, M, Dunlop, JWC, Zaslansky, P, Fratzl, Peter, Seto, J., Jahnen-Dechent, Wilhelm, Fratzl Peter   +87 more
core   +1 more source

The growth plate: a physiologic overview

EFORT Open Reviews, 2020
The growth plate is the cartilaginous portion of long bones where the longitudinal growth of the bone takes place. Its structure comprises chondrocytes suspended in a collagen matrix that go through several stages of maturation until they finally die, and are replaced by osteoblasts, osteoclasts, and lamellar bone.
openaire   +2 more sources