Results 51 to 60 of about 870,777 (309)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Differentiation of the brain vasculature : the answer came blowing by the Wnt

, 2010
Vascularization of the vertebrate brain takes place during embryonic development from a preformed perineural vascular plexus. As a consequence of the intimate contact with neuroectodermal cells the vessels, which are entering the brain exclusively via ...
Liebner, Stefan, Plate, Karl, Stefan Liebner, Karl H Plate   +3 more
core   +1 more source

Analytical study on growth-induced axisymmetric deformations and shape-control of circular hyperelastic plates

, 2022
Growth of soft material plates is commonly observed in nature. However, the relations between growth fields and shape changes of the plate samples remain poorly understood.
Du, Ping, Wang, Qiongyu, Li, Zhanfeng, Hossain, Mokarram, Kadapa, Chennakesava, Wang, Jiong   +5 more
core   +1 more source

Factores mecánicos en enfermedades osteocondrales Mechanical factors of osteochondral diseases

Revista Cubana de Investigaciones Biomédicas, 2011
Las osteocondrosis son enfermedades que afectan al esqueleto en crecimiento y que en sus estados avanzados producen deformaciones y cambios de los patrones de actividad física y movimiento del individuo.
Alejandro Gamboa Márquez, Diego Alexander Garzón-Alvarado   +1 more
doaj  

Tibial tubercle avulsion fractures in children and adolescents

Pediatric Discovery
Tibial tubercle avulsion fractures (TTAFs) are uncommon injuries in the pediatric population, predominantly affecting children and adolescents who are approaching skeletal maturity and frequently engage in high‐energy activities. Despite of their rarity,
Hailun Yao, Yuanlin He, Xiang Li, Mingyan Shi, Peikang Wang, Man Zhang, Xinkai Zhang, Xing Liu   +7 more
doaj   +1 more source

Depletion of SMN protein in mesenchymal progenitors impairs the development of bone and neuromuscular junction in spinal muscular atrophy

eLife
Spinal muscular atrophy (SMA) is a neuromuscular disorder characterized by the deficiency of the survival motor neuron (SMN) protein, which leads to motor neuron dysfunction and muscle atrophy.
Sang-Hyeon Hann, Seon-Yong Kim, Ye Lynne Kim, Young-Woo Jo, Jong-Seol Kang, Hyerim Park, Se-Young Choi, Young-Yun Kong   +7 more
doaj   +1 more source

Effects of Glucocorticoids on the Growth Plate [PDF]

, 2010
Glucocorticoids have a direct, inhibitory effect on the growth plate, as demonstrated by in vivo and organ culture studies. Glucocorticoids slow longitudinal bone growth by inhibiting chondrocyte proliferation, hypertrophy, and cartilage matrix synthesis. The molecular mediators of these effects are poorly understood.
Julian C, Lui, Jeffrey, Baron
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Potential Effects of Oral Isotretinoin on Growth Plate and Height

, 2023
Longitudinal growth and puberty are the result of a complex interaction of genetic, hormonal, nutritional, and environmental factors. Acne vulgaris is a chronic disease of the pilosebaceous unit that affects 85% of adolescents worldwide.
Cesar Luiz Boguszewski, Adriane A. Cardoso-Demartini, Margaret C. S. Boguszewski   +2 more
core   +1 more source

A Theoretical Link Between the GH/IGF-1 Axis and Cytokine Family in Children: Current Knowledge and Future Perspectives

Children
Background/Objectives: Growth in childhood and adolescence is influenced by a complex interaction of genetic, environmental, and hormonal factors, with growth hormone (GH) and insulin-like growth factor 1 (IGF-1) playing crucial roles in linear growth ...
Ignazio Cammisa, Donato Rigante, Clelia Cipolla   +2 more
doaj   +1 more source