Results 11 to 20 of about 6,474,870 (228)

Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ : prostaglandin E2 dependent proliferation of growth plate chondrocytes [PDF]

open access: yes, 2006
Prostaglandin E2 (PGE2) plays an important role in bone development and metabolism. To interfere therapeutically in the PGE2 pathway, however, knowledge about the involved enzymes (cyclooxygenases) and receptors (PGE2 receptors) is essential.
Nüsing, Rolf M.   +9 more
core   +1 more source

The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438 [PDF]

open access: yes, 2007
Long-term use of glucocorticoids (GC) can cause growth retardation in children due to their actions on growth plate chondrocytes. AL-438, a non-steroidal anti-inflammatory agent that acts through the glucocorticoid receptor (GR) retains full anti ...
Farquharson, C   +7 more
core   +1 more source

Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'

open access: yeseLife, 2019
We respond to concerns expressed by Pacifici and Shore (2019) about a recent paper (Lees-Shepard and Goldhamer, 2018a) in which we reported that the drug palovarotene can have severe side effects in a mouse model of fibrodysplasia ossificans progressiva.
David J Goldhamer, John B Lees-Shepard
doaj   +1 more source

The Hunt Is On! In Pursuit of the Ideal Stem Cell Population for Cartilage Regeneration

open access: yesFrontiers in Bioengineering and Biotechnology, 2022
Cartilage injury and degeneration are hallmarks of osteoarthritis (OA), the most common joint disease. OA is a major contributor to pain, loss of function, and reduced quality of life.
T. Mark Campbell   +11 more
doaj   +1 more source

A Computed Microtomography Method for Understanding Epiphyseal Growth Plate Fusion

open access: yesFrontiers in Materials, 2018
The epiphyseal growth plate is a developmental region responsible for linear bone growth, in which chondrocytes undertake a tightly regulated series of biological processes. Concomitant with the cessation of growth and sexual maturation, the human growth
Katherine A. Staines   +4 more
doaj   +1 more source

Effect of Allium fistulosum Extracts on the Stimulation of Longitudinal Bone Growth in Animal Modeling Diet-Induced Calcium and Vitamin D Deficiencies

open access: yesApplied Sciences, 2021
Allium fistulosum is a perennial plant species grown worldwide belonging to the family Liliaceae. In Korean medicine, it is referred to as Chongbaek (CB), and it is prescribed for symptoms associated with the common cold due to its antipyretic properties.
Jin Ah Ryuk   +3 more
doaj   +1 more source

Bone wax in the treatment of partial epiphysiodesis of distal femoral growth plate: Case report at 10-year follow-up

open access: yesFrontiers in Surgery, 2022
The growth plate is the weakest structure in the skeleton of a child and a frequent site of injury or fracture; physeal injuries represent 15%–30% of all fractures in children.
Luca Basiglini   +5 more
doaj   +1 more source

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