Results 11 to 20 of about 18,138 (288)

GSDMD contributes to myocardial reperfusion injury by regulating pyroptosis

Frontiers in Immunology, 2022
BackgroundGasdermin D (GSDMD) plays an essential role in the pathway of pyroptosis. However, whether GSDMD participates in myocardial ischaemia/reperfusion injury (MI/RI) remains poorly understood.MethodsSerum levels of GSDMD and IL-18 in ST-segment ...
Xiaomiao Ye, Peng Zhang, Yuting Zhang, Jingyun Luan, Caili Xu, Zhengyu Wu, Dianwen Ju, Dianwen Ju, Wei Hu   +8 more
doaj   +3 more sources

GSDMD-mediated pyroptosis promotes cardiac remodeling in pressure overload

Clinical and Experimental Hypertension, 2023
Background Gasdermin D (GSDMD) forms membrane pores to execute pyroptosis. But the mechanism of how cardiomyocyte pyroptosis induces cardiac remodeling in pressure overload remains unclear.
Jieyun You, Xuan Li, Fangjie Dai, Jun Liu, Qi Zhang, Wei Guo   +5 more
doaj   +3 more sources

HDAC4-mediated deacetylation of GSDMD prevents pyroptosis by inhibiting GSDMD ubiquitination [PDF]

, 2023
AbstractGasdermin D (GSDMD) functions as a key pyroptotic executor and induces cytokine secretion after cleavage by inflammatory caspases. However, less is known about the role of posttranslational modifications (PTMs) in GSDMD-mediated pyroptosis. Here, we report that GSDMD can be acetylated at Lysine 248 residue and the acetylation of GSDMD promotes ...
Weilv Xu, Xinyue Li, Danyue Li, Xinyu Fu, Nan Chen, Qian Lv, Yuhua Shi, Suhui He, Lu Dong, Yang Yang, Fushan Shi   +10 more
openalex   +2 more sources

Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis

Cell Death and Disease
Gasdermin D (GSDMD) functions as a pivotal executor of pyroptosis, eliciting cytokine secretion following cleavage by inflammatory caspases. However, the role of posttranslational modifications (PTMs) in GSDMD-mediated pyroptosis remains largely ...
Weilv Xu, Qiao Jin, Xinyue Li, Danyue Li, Xinyu Fu, Nan Chen, Qian Lv, Yuhua Shi, Suhui He, Lu Dong, Yang Yang, Yuqi Yan, Fushan Shi   +12 more
doaj   +3 more sources

Snapshot of a Deadly Embrace: The Caspase-1-GSDMD Interface [PDF]

Immunity, 2020
Proteolytic maturation of the pore-forming protein gasdermin D (GSDMD) by inflammasome-activated caspase-1 is crucial for initiating pyroptosis, a lytic form of cell death. In this issue of Immunity, Lui et al. report the X-ray structure of the caspase-1-GSDMD complex, mapping the interaction interfaces that determine recognition and cleavage of GSDMD ...
Lieselotte Vande Walle, Mohamed Lamkanfi
openalex   +3 more sources

Mitochondrial GSDMD Pores DAMPen Pyroptosis [PDF]

Immunity, 2020
Noncanoncial inflammasome activation by cytosolic lipopolysaccharide (LPS) causes pyroptotic cell death facilitated by gasdermin D (GSDMD) pore formation. In this issue of Immunity, Huang et al. describe how cytosolic LPS in endothelial cells does not cause cell death but restrains endothelial cell proliferation.
Katherine C, Barnett, Jenny P-Y, Ting
openaire   +2 more sources

Review: the role of GSDMD in sepsis

Inflammation Research, 2022
Gasdermin D (GSDMD) is a cytoplasmic protein that is encoded by the gasdermin family GSDMD gene and is the ultimate executor of pyroptosis. Pyroptosis is a mode of lysis and inflammation that regulates cell death, ultimately leading to cell swelling and rupture.
Shao, Ruifei, Lou, Xiran, Xue, Jinfang, Ning, Deyuan, Chen, Guobing, Jiang, Lihong   +5 more
openaire   +2 more sources

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance The protein gasdermin D (GSDMD) is the physiological substrate of inflammatory caspases and plays key roles in cell pyroptosis upon microbial infection and associated danger signals. GSDMD, as well as other gasdermin members, can bind lipid and form pore structures to induce pyroptosis.
Siyun, Kuang, Jun, Zheng, Hui, Yang, Suhua, Li, Shuyan, Duan, Yanfang, Shen, Chaoneng, Ji, Jianhua, Gan, Xue-Wei, Xu, Jixi, Li   +9 more
openaire   +2 more sources

GSDMD Deficiency Protects Against Aortic Rupture [PDF]

, 2021
ABSTRACTObjectiveAortic ruptures are fatal consequences of aortic aneurysms with macrophage accumulation being a hallmark at the site of ruptures. Pyroptosis is critical in macrophage-mediated inflammation. This study determined effects of pyroptosis on aortic dilation and rupture using GSDMD deficient mice.Approach and ResultsIn an initial study ...
Dien Ye, Deborah A. Howatt, Zhenyu Li, Alan Daugherty, Hong S. Lu, Congqing Wu   +5 more
openaire   +1 more source

Human polymorphisms in GSDMD alter the inflammatory response [PDF]

Journal of Biological Chemistry, 2020
Exomic studies have demonstrated that innate immune genes exhibit an even higher degree of variation than the majority of other gene families. However, the phenotypic implications of this genetic variation are not well understood, with effects ranging from hypomorphic to silent to hyperfunctioning.
Joseph K. Rathkey, Tsan S. Xiao, Derek W. Abbott   +2 more
openaire   +2 more sources