Results 111 to 120 of about 5,144 (202)

Celastrol activates caspase-3/GSDME-dependent pyroptosis in tumor cells by inducing endoplasmic reticulum stress

Journal of Traditional Chinese Medical Sciences
Objective: To investigate the pyroptosis-inducing effects of celastrol on tumor cells and to explore the potential mechanisms involved, specifically focusing on the role of the caspase-3/gasdermin E (GSDME) signaling pathway and the impact of endoplasmic
Jiajian Guo, Dongxiao Cui, Yuping Tang, Sanjiao Wang, Cuiyan Ma, Wenfu Ma   +5 more
doaj   +1 more source

Norovirus co-opts NINJ1 for selective protein secretion [PDF]

Plasma membrane rupture by Ninjurin-1 (NINJ1) executes programmed cell death, releasing large cellular damage-associated molecular patterns (DAMPs). However, the regulation and selectivity of NINJ1-mediated DAMP release remain unexplored.
Beatty, Wandy L, et al.,, Orvedahl, Anthony, Song, Jaewon   +3 more
core   +2 more sources

Mechanism of motoneuronal and pyramidal cell death in amyotrophic lateral sclerosis and its potential therapeutic modulation [PDF]

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder clinically characterized by muscle atrophy and progressive paralysis. Loss of motoneurons and pyramidal cells is thought to be the center piece of the complex and multifaceted ALS ...
Csont Tamás Bálint, Erdélyi-Furka Barbara Fanni, Kádár Zalán, Molnár-Gáspár Renáta, Nógrádi Bernát, Nógrádi-Halmi Dóra   +5 more
core   +1 more source

Renal tubular GSDME protects cisplatin nephrotoxicity by impeding OGT-STAT3-S100A7A axis in male mice

Nature Communications
Gasdermin E (GSDME) is known as a key executive protein of pro-inflammatory pyroptosis. However, the function diversity of GSDME needs further investigation. Here, we show that GSDME expression is downregulated in kidney tissues after cisplatin treatment
Qingzhou Chen, Pengxiao Sun, Jiaxin Zhou, Tantan Long, An Xiao, Zhuoliang Liu, Shihui Xu, Wenjing Lei, Rui Zhang, Jianwei Tian, Miaomiao Zhou, Zheng Hu, Fengxin Zhu, Jing Nie   +13 more
doaj   +1 more source

NLRP1 and DNA damage in relation to IL-1b release in lung fibroblasts infected with respiratory syncytial virus [PDF]

Respiratorisk syncytialt virus (RSV) er en viktig årsak til alvorlige luftveisinfeksjoner, spesielt hos barn og eldre. Overdreven inflammasjon under RSV-infeksjon er knyttet til forhøyede nivåer av IL-1β sekresjon.
Brenden, Kine Jeanette
core  

Emerging role of immunogenic cell death in cancer immunotherapy. [PDF]

Cancer immunotherapy, such as immune checkpoint blockade (ICB), has emerged as a groundbreaking approach for effective cancer treatment. Despite its considerable potential, clinical studies have indicated that the current response rate to cancer ...
Arimoto, Kei-Ichiro, Liu, Mengdan, Miyauchi, Sayuri, Zhang, Dong-Er   +3 more
core   +1 more source

Miltirone induces GSDME-dependent pyroptosis in colorectal cancer by activating caspase 3

Heliyon
Colorectal cancer (CRC) is a common and malignant tumor, ranking as the third most common cancer in men and the second most common cancer in women. Pyroptosis, a recently described programmed cell death mechanism mediated by the GSDM family, has emerged as an immunogenic mechanism for chemotherapy drugs in tumor treatment.
Guangwei Zheng, Zhipeng Fang, Zhenlv Lin, Guoxian Guan   +3 more
openaire   +3 more sources

Harnessing redox reactions for anticancer effects: A copper(II) Schiff base complex induces apoptosis in HepG2 liver cancer cells via ROS generation [PDF]

This study uncovers the potential of a copper(II) Schiff base complex, CuL2+, to access the Cu(I) oxidation state and generate reactive oxygen species (ROS), highlighting its significance in eventual therapeutic applications.
Abruscato G., Barone G., Bonsignore R., Cataldo S., Chiarelli R., D'Anna L., Ganci D., Le Chevalier M., Luparello C., Pettignano A., Quideau O., Rubino S.   +11 more
core   +1 more source

GSDME : from tumor suppressor gene to biomarker

, 2019
Abstract: abstract not ...
openaire   +1 more source

Ocifisertib alleviates the gasdermin D-independent pyroptosis of nucleus pulposus cells by targeting GSDME

Scientific Reports
This study aimed to elucidate the cellular and molecular mechanisms of GSDME in GSDMD independent nucleus pulposus (NP) cell pyroptosis. We analyzed microarray datasets to identify differentially expressed genes (DEGs) in the progression of ...
Yu Lin, Qiyong Chen, Shaoqiang Liu, Boling Liu   +3 more
doaj   +1 more source