Results 111 to 120 of about 6,248 (265)

Role for Caspase-8 in the Release of IL-1β and Active Caspase-1 from Viable Human Monocytes during Toxoplasma gondii Infection. [PDF]

Monocytes are actively recruited to sites of infection and produce the potent proinflammatory cytokine IL-1β. We previously showed that IL-1β release during Toxoplasma gondii infection of primary human monocytes requires the NLRP3 inflammasome and ...
Batarseh, Sarah N, Kao, Tiffany H, Kim, Samuel C, Lodoen, Melissa B, Mallya, Sharmila, Matsuno, Stephanie Y, Pandori, William J, Shin, Ji-Hun   +7 more
core   +1 more source

From Exciton Dynamics to Cell Fate: A Carbon Dot Based NIR Photocatalytic Platform for Pyroptosis via Self‐Trapped Excitons

Advanced Functional Materials, Volume 35, Issue 51, December 16, 2025.
A facile and effective method to boost NIR light induced photocatalysis based on nontoxic NIR emissive carbon dots (nir‐CDs) via Self‐trapped excitons, showing that both O2− • and •OH can be generated from nir‐CDs under NIR laser irradiation. Abstract Near‐infrared (NIR) light‐triggered photocatalytic therapy remains a critical challenge in efficient ...
Qingcheng Wang, Quansheng Cheng, Bingzhe Wang, Tesen Zhang, Yupeng Liu, Ruifeng Zheng, Shi Chen, Guichuan Xing, Songnan Qu   +8 more
wiley   +1 more source

Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling

Journal of experimental & clinical cancer research : CR
High expression of ubiquitin ligase MDM2 is a primary cause of p53 inactivation in many tumors, making it a promising therapeutic target. However, MDM2 inhibitors have failed in clinical trials due to p53-induced feedback that enhances MDM2 expression ...
Wei Chen, Kai-Bin Yang, Yuan Zhang, Zai-Shan Lin, Jin-Wei Chen, Si-Fan Qi, Chenfei Wu, G. Feng, Da-jun Yang, Ming Chen, Xiao-Feng Zhu, Xuan Li   +11 more
semanticscholar   +1 more source

Engineered biomimetic cisplatin-polyphenol nanocomplex for chemo-immunotherapy of glioblastoma by inducing pyroptosis [PDF]

© 2025. The Author(s).Glioblastoma multiforme (GBM) is characterized by pronounced immune escape and resistance to chemotherapy-induced apoptosis. Preliminary investigations revealed a marked overexpression of gasdermin E (GSDME) in GBM.
Conde, João, Han, Ruyue, Hao, Xinyan, He, Jun, Hu, Xiongbin, Li, Yongjiang, Liao, Dehua, Liu, Jiayi, Peng, Yanjin, Sun, Pengcheng, Tang, Tiantian, Tang, Yucheng, Wang, Jiemin, Wang, Ming, Wu, Junyong, Xiang, Daxiong, Xu, Wenjie, Zhou, Min   +17 more
core   +1 more source

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR‐NFκB Pathway

Advanced Science, Volume 12, Issue 46, December 11, 2025.
This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen, Nian Liu, Qian Tao, Jie Wu, Jinyu Huang, Can Lu, Qiuqiu Li, Liangfang Shen, Xiang Chen, Cong Peng   +9 more
wiley   +1 more source

Caerin 1.1 and 1.9 peptides induce acute caspase 3/GSDME-mediated pyroptosis in epithelial cancer cells

Scientific Reports
Caerin peptides exhibit a dual role in cancer treatment by directly killing cancer cells and modulating the tumour microenvironment to enhance anti-tumour immunity. This study investigates the mechanisms underlying caerin 1.1/1.9-induced acute cell death
Yuandong Luo, Junjie Li, Quanlan Fu, Pingping Zhang, Xinyi Song, Mengqi Liu, Rongmi Mo, Jiawei Fu, Shuxian Tang, Jialing Wu, Xiaodan Yang, Xiaosong Liu, Tianfang Wang, Guoying Ni   +13 more
semanticscholar   +1 more source

LL37 complexed to double-stranded RNA induces RIG-I-like receptor signalling and Gasdermin E activation facilitating IL-36γ release from keratinocytes [PDF]

The Interleukin-36 (IL-36) cytokine family have emerged as important players in mounting an inflammatory response at epithelial barriers and tailoring appropriate adaptive immune responses.
Danis Judit, French Lars E., Girousi Eleftheria, Keller Jennifer, Kemény Lajos, Krehl Isabella, Kündig Thomas M., Meier-Schiesser Barbara, Mellett Mark, Pascolo Steve, Satoh Takashi K., Széll Márta, Wong W. Wei-Lynn   +12 more
core   +1 more source

TNFSF15 inhibits progression of diabetic retinopathy by blocking pyroptosis via interacting with GSDME

Cell Death and Disease
Diabetic retinopathy is a common microvascular complication of diabetes and a leading cause of blindness. Pyroptosis has emerged as a mechanism of cell death involved in diabetic retinopathy pathology.
Hongkun Zhao, Yating Dai, Yunqin Li, Juanjuan Li, Hua Li   +4 more
doaj   +1 more source

Caspase-3 Promotes Diabetic Kidney Disease Through Gasdermin E-Mediated Progression to Secondary Necrosis During Apoptosis

Diabetes, Metabolic Syndrome and Obesity, 2020
Si Wen,1,* Zhao-Hua Wang,2,* Cong-Xiao Zhang,1 Ying Yang,1 Qiu-Ling Fan1 1Department of Nephrology, First Hospital of China Medical University, Shenyang, People’s Republic of China; 2Affiliated Dalian Friendship Hospital of Dalian Medical ...
Wen S, Wang ZH, Zhang CX, Yang Y, Fan QL
doaj  

Palmitoylation at a conserved cysteine residue facilitates gasdermin D-mediated pyroptosis and cytokine release [PDF]

Gasdermin D (GSDMD)-mediated pyroptotic cell death drives inflammatory cytokine release and downstream immune responses upon inflammasome activation, which play important roles in host defense and inflammatory disorders. Upon activation by proteases, the
Bracey, Syrena, Dickinson, Bryan C., Lan, Tong, Li, Ling, Li, Sai, Liu, Zhonghua, Miyagi, Masaru, Osme, Abdullah, Pizarro, Theresa T., Vidmar, Kaylynn, Wang, Chuanping, Willard, Belinda, Xiao, Tsan Sam   +12 more
core   +1 more source