Results 131 to 140 of about 4,201 (162)
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GSDME: A Potential Ally in Cancer Detection and Treatment
Trends in Cancer, 2021Gasdermin E (GSDME) is an executioner of caspase-3 mediated regulated pyroptosis, and as such plays an important role in several cancers. Recent findings highlighted the potential of GSDME as a biomarker that can be implemented in cancer diagnosis, monitoring, and therapy.
J Ibrahim, K Op De Beeck
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Identification of duck GSDME: Tissue distribution, proteolysis and cellular location
Cytokine, 2022Gasdermin E (GSDME) is a member of the gasdermin family. Cleavage of mammalian GSDME by apoptotic caspases or granzyme proteases liberates the N-terminal effector domain (GSDME-N), which is capable of forming membrane pores and executing inflammation and cell death.
Anchun Cheng, Renyong Jia
exaly +3 more sources
GSDME Is Related to Prognosis and Response to Chemotherapy in Oral Cancer
Journal of Dental Research, 2022Gasdermin E (GSDME), as the major executive protein of pyroptosis, has been considered to be linked to antitumor immunity in recent years. However, the role of GSDME in oral squamous cell carcinoma (OSCC) remains to be elucidated.
Wang, S. +9 more
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P06.02.B GSDME-MEDIATED PYROPTOSIS IN GLIOBLASTOMA
Neuro-Oncology, 2023Abstract BACKGROUND Immunotherapeutic strategies have largely failed for glioblastoma , the most frequent primary brain tumor. Beyond apoptosis and autophagy, little is known about cell death mechanisms in glioblastoma, despite their potential impact on the immune microenvironment.
E Solel +6 more
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GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy
Cell Death & Differentiation, 2021Renal tubular cell (RTC) death and inflammation contribute to the progression of obstructive nephropathy, but its underlying mechanisms have not been fully elucidated. Here, we showed that Gasdermin E (GSDME) expression level and GSDME-N domain generation determined the RTC fate response to TNFα under the condition of oxygen-glucose-serum deprivation ...
Yinshuang Li +13 more
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Caspase-3/GSDME mediated pyroptosis: A potential pathway for sepsis
International Immunopharmacology, 2023The inflammatory response is one of the host's mechanisms to combat pathogens. Normal and controlled inflammation can accelerate the clearance of pathogens. However, in sepsis, the host often exhibits an excessive inflammatory response to infection, leading to tissue and organ damage.
Chaoze Jiao +8 more
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GSDME mediates caspase-3-dependent pyroptosis in gastric cancer
Biochemical and Biophysical Research Communications, 2018Gastric cancer is a malignancy that starts from the cells in the stomach with relatively low overall survival rate. Chemotherapy following resection surgery has been recommended as a curative strategy for gastric cancer. However, the mechanism of the chemotherapy drugs on gastric cancer is not completely understood.
Yubin, Wang +5 more
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The deafness gene GSDME: its involvement in cell apoptosis, secondary necrosis, and cancers
Naunyn-Schmiedeberg's Archives of Pharmacology, 2019Gasdermin E (GSDME), also called DFNA5, is a member of the gasdermin family. GSDME is involved in the regulation of apoptosis and necrosis. The N-terminal domain of GSDME displays an apoptosis-inducing activity while the C-terminal domain may serve as an apoptosis-inhibiting regulator by shielding the N-terminal domain.
Jun Peng, Xiuju Luo, Luo Xiu-Ju
exaly +3 more sources
The Journal of Steroid Biochemistry and Molecular Biology
Expression of the critical pyroptosis protein gasdermin E (GSDME) has been reported to be regulated by DNA methylation and negatively correlated with the expression of estrogen receptor (ER) in breast cancer tissues, suggesting that estrogen-induced target gene methylation may be involved in the regulation of GSDME expression in breast cancer cells. To
Yu Pan +10 more
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Expression of the critical pyroptosis protein gasdermin E (GSDME) has been reported to be regulated by DNA methylation and negatively correlated with the expression of estrogen receptor (ER) in breast cancer tissues, suggesting that estrogen-induced target gene methylation may be involved in the regulation of GSDME expression in breast cancer cells. To
Yu Pan +10 more
openaire +2 more sources