Results 141 to 150 of about 4,201 (162)

GSDME-mediated pyroptosis modulates the immunosuppressive microenvironment in lung adenocarcinoma

Acta Pharmacologica Sinica
Despite the increasing recognition of pyroptosis, particularly that involving GSDME, its precise impact on tumor prognosis and the immune microenvironment remains elusive, necessitating a comprehensive investigation in the context of lung adenocarcinoma (LUAD).
Guang-Sheng, Zhu, Xuan-Guang, Li, Pei-Jun, Cao, Ya-Nan, Wang, Ying-Jie, Wang, Zi-He, Zhang, Bo-Shi, Li, Pei-Jie, Chen, Yong-Wen, Li, Chen, Chen, Hong-Bing, Zhang, Hong-Yu, Liu, Jun, Chen   +12 more
openaire   +2 more sources

Cisplatin promotes pyroptosis of gastric cancer cells by activating GSDME

2023
ABSTRACT According to studies, numerous chemotherapeutic drugs can facilitate programmed cell death via pyroptosis. Clarifying the mechanism by which cisplatin kills gastric cancer cells is crucial for enhancing gastric cancer’s sensitivity to chemotherapy and elucidating the mechanism of drug resistance in gastric cancer.
Xianglai Jiang, Yongfeng Wang, Chenyu Wang, Haizhong Ma, Miao Yu, Hui Cai   +5 more
openaire   +1 more source

Full-length GSDME mediates pyroptosis independent from cleavage

Nature Cell Biology
Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing pyroptosis. We here discovered a form of pyroptosis mediated by full-length (FL) GSDME without proteolytic cleavage. Intense ultraviolet-C irradiation-triggered DNA damage activates nuclear PARP1, leading to extensive formation of ...
Bo Zhou, Zhi-hong Jiang, Meng-ran Dai, Yuan-li Ai, Li Xiao, Chuan-qi Zhong, Liu-Zheng Wu, Qi-tao Chen, Hang-zi Chen, Qiao Wu   +9 more
openaire   +2 more sources

[Research progress on GSDME-mediated cell pyroptosis resulting in GSDME type hearing loss].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Pyroptosis is a novel mode for programmed cell death discovered and confirmed in recent years. The Gasdermins (GSDMs) family is a key effector molecule mediating pyroptosis. As an important cause of extensive inflammatory damage and side effects of conventional chemotherapy drugs, anomalous pyroptosis has also been associated with hearing loss, tumor ...
Liting, Peng, Xi, Wang, Weiqian, Wang, Jincao, Xu, Xue, Gao   +4 more
openaire   +1 more source

RETRACTED: Streptococcus anginosus promotes gastric cancer progression via GSDME-mediated pyroptosis pathway: Molecular mechanisms of action of GSDME, cleaved caspase-3, and NLRP3 proteins

International Journal of Biological Macromolecules
Streptococcus vasculosus is a common oral and intestinal symbiotic bacteria, but it can transform into a pathogen under certain conditions, affecting the host's immune response. Studies have shown that Streptococcus vasculosus may promote tumor growth and metastasis by activating host inflammatory responses.
Zeshen, Wang, Ruishu, Mou, Shiyang, Jin, Qiancheng, Wang, Yuming, Ju, Pengcheng, Sun, Rui, Xie, Kuan, Wang   +7 more
openaire   +2 more sources

GSDME unlocks astrocyte-driven neurotoxicity in Alzheimer’s Disease

SUMMARY Astrocytic calcium dysregulation and reactivity precede Aβ deposition in amyloid-β deposition in Alzheimer’s disease (AD) but the neurotoxic mechanisms remain unclear. We show that GSDME acts as a switch, linking MAM-mediated calcium release to astrocyte-driven neurotoxicity.
Xueman Xie, Chenhui Ji, Jinmei Xu, Xiaoyang Lu, Guigui Guo, Xiaomin Wu, Wenjing Liu, Yaozhen Chen, Yuanxing Zhang, Jintao Wang, Jianping Li, Xingbin Hu, Shouwen Chen, Gang Wang, Qin Liu   +14 more
openaire   +1 more source

GSDME as an executioner of chemotherapy-induced cell death

Science China Life Sciences, 2017
Xiaoliang, Yu, Sudan, He
openaire   +2 more sources

The pyroptotic role of Caspase-3/GSDME signalling pathway among various cancer: A Review

International Journal of Biological Macromolecules, 2023
Waleed Hassan Al-Maliki
exaly  

CASP3-GSDME-mediated trophoblast pyroptosis contributes to systemic inflammation

Abstract Early-onset preeclampsia (EOPE) is associated with excessive apoptosis and inflammation, but the mechanistic link between these processes remains enigma. Here, we report elevated circulating pro-apoptotic proteins in EOPE patients at early pregnancy, along with concurrent CASP3 activation and GSDME cleavage ...
Baoying Huang, Shilei Bi, Weinan Deng, Lili Du, Lijun Huang, Yifan Wang, Lizi Zhang, Zhoushan Feng, Tengfei Liu, Julia Kzhyshkowska, Zhaowei Tu, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +14 more
openaire   +1 more source

Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX/GSDME pathway

Acta Pharmacologica Sinica, 2023
Mao Xin-Liang
exaly