Frontiers in PharmacologyColorectal cancer (CRC) patients with a microsatellite-stable (MSS) status exhibit poor responsiveness to PD-1/PD-L1 blockade. Pyroptosis induction may resensitize MSS tumors to PD-1/PD-L1 blockade; however, the expression of GSDME, a key executor of ...
Dongsheng Tan +6 more
doaj +1 more source
Bioorthogonal Activation of Deep Red Photoredox Catalysis Inducing Pyroptosis [PDF]
The revolutionary impact of photoredox catalytic processes has ignited novel avenues for exploration, empowering us to delve into nature in unprecedented ways and to pioneer innovative biotechnologies for therapy and diagnosis.
Fox, Joseph M +6 more
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CDC5L binds to ELAVL1 to inhibit pyroptosis in hepatocellular carcinoma through the Caspase 3/GSDME signaling pathway. [PDF]
Int J Mol MedHepatocellular carcinoma (HCC) is associated with elevated rates of illness and mortality, posing a significant challenge to global health. Elevated levels of cell division cycle 5 like (CDC5L) in HCC predict a poor prognosis.
Liang S +6 more
europepmc +2 more sources
Total extract of Abelmoschus manihot L. alleviates uric acid-induced renal tubular epithelial injury via inhibition of caspase-8/caspase-3/NLRP3/GSDME signaling [PDF]
, 2022 Zhihui Ding +13 more
openalex +1 more source
Pyroptosis: A Novel Therapeutic Target for Bioactive Compounds in Human Disease Treatment? A Narrative Review [PDF]
Background/Objectives: Bioactive compounds possess the ability to maintain health and improve diseases by regulating inflammation and cell death processes.
Armas Diaz Y +10 more
core +1 more source
American journal of cancer researchPyroptosis, a newly discovered mode of programmed cell death (PCD), is important in the regulation of cancer development. High mobility group box 1 (HMGB1) is a non-histone nuclear protein that is closely related to tumor development and chemotherapy resistance.
Chen-Ying, Fan +7 more
openaire +1 more source
Norovirus co-opts NINJ1 for selective protein secretion [PDF]
Plasma membrane rupture by Ninjurin-1 (NINJ1) executes programmed cell death, releasing large cellular damage-associated molecular patterns (DAMPs). However, the regulation and selectivity of NINJ1-mediated DAMP release remain unexplored.
Beatty, Wandy L +3 more
core +2 more sources
Mechanism of motoneuronal and pyramidal cell death in amyotrophic lateral sclerosis and its potential therapeutic modulation [PDF]
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder clinically characterized by muscle atrophy and progressive paralysis. Loss of motoneurons and pyramidal cells is thought to be the center piece of the complex and multifaceted ALS ...
Csont Tamás Bálint +5 more
core +1 more source
NLRP1 and DNA damage in relation to IL-1b release in lung fibroblasts infected with respiratory syncytial virus [PDF]
Respiratorisk syncytialt virus (RSV) er en viktig årsak til alvorlige luftveisinfeksjoner, spesielt hos barn og eldre. Overdreven inflammasjon under RSV-infeksjon er knyttet til forhøyede nivåer av IL-1β sekresjon.
Brenden, Kine Jeanette
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