Results 141 to 150 of about 6,248 (265)

Testosterone‐Induced Pyroptotic Death of Ovarian Granulosa Cells in PCOS Might Involve Both GSDMD and GSDME, the Latter Possibly Enabling a Crosstalk Between Apoptosis and Pyroptosis [PDF]

Caglar Berk
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Emerging role of immunogenic cell death in cancer immunotherapy. [PDF]

Cancer immunotherapy, such as immune checkpoint blockade (ICB), has emerged as a groundbreaking approach for effective cancer treatment. Despite its considerable potential, clinical studies have indicated that the current response rate to cancer ...
Arimoto, Kei-Ichiro, Liu, Mengdan, Miyauchi, Sayuri, Zhang, Dong-Er   +3 more
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Harnessing redox reactions for anticancer effects: A copper(II) Schiff base complex induces apoptosis in HepG2 liver cancer cells via ROS generation [PDF]

This study uncovers the potential of a copper(II) Schiff base complex, CuL2+, to access the Cu(I) oxidation state and generate reactive oxygen species (ROS), highlighting its significance in eventual therapeutic applications.
Abruscato G., Barone G., Bonsignore R., Cataldo S., Chiarelli R., D'Anna L., Ganci D., Le Chevalier M., Luparello C., Pettignano A., Quideau O., Rubino S.   +11 more
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Mesenchymal stem cells ameliorate H9N2-induced acute lung injury by inhibiting caspase-3-GSDME-mediated pyroptosis of lung alveolar epithelial cells

, 2023
Mengwei Zhang, Guofeng Xu, Xin Zhou, Min Luo, Ning Ma, Xing Wang, Zhibin Wang, Hongmei Tang, Xiaoyun Wang, Yuejiao Li, Xiefang Yuan, Yuying Li, Yuying Li, Yuying Li   +13 more
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Miltirone induces GSDME-dependent pyroptosis in colorectal cancer by activating caspase 3

Heliyon
Colorectal cancer (CRC) is a common and malignant tumor, ranking as the third most common cancer in men and the second most common cancer in women. Pyroptosis, a recently described programmed cell death mechanism mediated by the GSDM family, has emerged as an immunogenic mechanism for chemotherapy drugs in tumor treatment.
Guangwei Zheng, Zhipeng Fang, Zhenlv Lin, Guoxian Guan   +3 more
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GSDME : from tumor suppressor gene to biomarker

, 2019
Abstract: abstract not ...
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Data from Molecular Targeted Therapies Elicit Concurrent Apoptotic and GSDME-Dependent Pyroptotic Tumor Cell Death

, 2023
Haijiao Lu, Shengzhe Zhang, Jie Wu, Minjiang Chen, Mei‐Chun Cai, Yujie Fu, Wenfeng Li, Jing Wang, Xiaojing Zhao, Zhuang Yu, Pengfei Ma, Guanglei Zhuang   +11 more
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Correction: Cold atmospheric plasma induces GSDME-dependent pyroptotic signaling pathway via ROS generation in tumor cells [PDF]

, 2022
Xiaorui Yang, Guodong Chen, Kaiyuan Yu, Miaomiao Yang, Shengjie Peng, Jie Ma, Feng Qin, Wei Cao, Shujun Cui, Lili Nie, Wei Han   +10 more
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Intravital molecular imaging reveals that ROS-caspase-3-GSDME-induced cell punching enhances humoral immunotherapy targeting intracellular tumor antigens [PDF]

, 2022
Bolei Dai, Ren Zhang, Shuhong Qi, Lei Liu, Xian Zhang, Deqiang Deng, Jie Zhang, Yilun Xu, Fanxuan Liu, Zheng Liu, Qingming Luo, Zhihong Zhang   +11 more
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Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil

, 2022
Bingxue Yang, Xinran Xie, Dazhao Lv, Jiajun Hu, Yuyun Chen, Zhaoyu Wu, Shuyue Luo, Shiyi Zhang   +7 more
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