Tubastatin A alleviates post-resuscitation myocardial damage possibly via inhibiting GSDME-mediated pyroptosis and MLKL-mediated necroptosis in a porcine model of cardiac arrest. [PDF]
Resusc PlusLai L +5 more
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GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis
Nature Communications, 2023 AbstractPyroptosis, a type of Gasdermin-mediated cell death, contributes to an exacerbation of inflammation. To test the hypothesis that GSDME-mediated pyroptosis aggravates the progression of atherosclerosis, we generate ApoE and GSDME dual deficiency mice.
Yuanyuan Wei, tao zheng, Zuyi Yuan
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GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy
Cell Death and Differentiation, 2021Renal tubular cell (RTC) death and inflammation contribute to the progression of obstructive nephropathy, but its underlying mechanisms have not been fully elucidated. Here, we showed that Gasdermin E (GSDME) expression level and GSDME-N domain generation determined the RTC fate response to TNFα under the condition of oxygen-glucose-serum deprivation ...
Hui Chen, Hong Chen, Hui Yao Lan
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P06.02.B GSDME-MEDIATED PYROPTOSIS IN GLIOBLASTOMA
Neuro-Oncology, 2023Abstract BACKGROUND Immunotherapeutic strategies have largely failed for glioblastoma , the most frequent primary brain tumor. Beyond apoptosis and autophagy, little is known about cell death mechanisms in glioblastoma, despite their potential impact on the immune microenvironment.
E Solel +6 more
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GSDME: A Potential Ally in Cancer Detection and Treatment
Trends in Cancer, 2021Gasdermin E (GSDME) is an executioner of caspase-3 mediated regulated pyroptosis, and as such plays an important role in several cancers. Recent findings highlighted the potential of GSDME as a biomarker that can be implemented in cancer diagnosis, monitoring, and therapy.
Ibrahim, Joe +2 more
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Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis
Acta Pharmaceutica Sinica B, 2020 Pyroptosis is a form of programmed cell death, and recently described as a new molecular mechanism of chemotherapy drugs in the treatment of tumors. Miltirone, a derivative of phenanthrene-quinone isolated from the root of Salvia miltiorrhiza Bunge, has been shown to possess anti-cancer activities.
Jun Chen
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Caspase-3/GSDME mediated pyroptosis: A potential pathway for sepsis
International Immunopharmacology, 2023The inflammatory response is one of the host's mechanisms to combat pathogens. Normal and controlled inflammation can accelerate the clearance of pathogens. However, in sepsis, the host often exhibits an excessive inflammatory response to infection, leading to tissue and organ damage.
Chaoze Jiao +8 more
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Bnip3 mediates doxorubicin-induced cardiomyocyte pyroptosis via caspase-3/GSDME
Life Sciences, 2020This study was aimed to investigate the role of GSDME-mediated pyroptosis in cardiac injury induced by Doxorubicin (DOX), and to evaluate the role of BH3-only protein Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 (Bnip3) in regulation of DOX-induced pyroptosis.HL-1 cardiomyocytes and C57BL/6J mice were treated by DOX to establish DOX-induced ...
Deling Yin
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Identification of duck GSDME: Tissue distribution, proteolysis and cellular location
Cytokine, 2022Gasdermin E (GSDME) is a member of the gasdermin family. Cleavage of mammalian GSDME by apoptotic caspases or granzyme proteases liberates the N-terminal effector domain (GSDME-N), which is capable of forming membrane pores and executing inflammation and cell death.
Yao, Cheng +19 more
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