Results 21 to 30 of about 6,248 (265)

Pharmacological activation of STAT1-GSDME pyroptotic circuitry reinforces epigenetic immunotherapy for hepatocellular carcinoma [PDF]

Gut
Background: Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for therapeutic development remain less understood ...
Chan, Stephen Lam, Chen, Shufen, Chen, Siyun, Cheng, Alfred Sze Lok, Feng, Yu, Kerr, David, Kwong, Tsz Tung, La Thangue, Nick, Leung, Howard, Liang, Jianxin, Liang, Liying, Liang, Zhixian, Lin, Yingnan, Liu, Yan, Lu, Jiahuan, Ma, Stephanie, Ren, Weida, Si-Tou, Willis Wai Yiu, Sun, Hanyong, Sung, Joseph J.Y., To, Ka Fai, Tong, Man, Tu, Yalin, Vong, Joaquim S.L., Wang, Jing, Wong, Patrick Pak Chun, Wu, Haoran, Xia, Qiang, Xiong, Zhewen, Yang, Weiqin, Yin, Baoyi, Zhang, Lingyun, Zhong, Chengpeng, Zhou, Jingying   +33 more
core   +5 more sources

Enhancing GSDME-induced pyroptosis through low-dose doxorubicin/biflavonoid derivative co-loaded nanodisc in hepatocellular carcinoma. [PDF]

Drug Deliv
The chemotherapeutic drug doxorubicin (DOX) has been demonstrated to trigger pyroptosis in tumor cells at exceptionally high concentrations. Nevertheless, the administration of DOX at suprapharmacological doses could cause acute off-target cytotoxicity ...
Wang Y, Fu Y, Wu M, Wan H, Chen X, Ge L, Shi C, Li Y, Zeng X, Wang T.   +9 more
europepmc   +3 more sources

Cholestane-3β,5α,6β-triol induces cancer cell death by activating GSDME-mediated pyroptosis [PDF]

Frontiers in Pharmacology
BackgroundTrihydroxysterols and their analogues accumulate in several pathologies, including neurodegenerative diseases, cancers, and atherosclerosis.
Jiaxi Chen, Yuan He, Min Zhao, Zihan Liu, Zixin Su, Chuanzhou Li, Chuanzhou Li, Chen Yang, Chen Yang, Jieping Zhang, Shuichun Mao, Hua Han, Zhenyu Cai, Wen Zhang, Wen Zhang   +14 more
doaj   +2 more sources

Antileukemic effect of venetoclax and hypomethylating agents via caspase-3/GSDME-mediated pyroptosis

Journal of Translational Medicine, 2023
Background The identifying of B-cell lymphoma 2 (Bcl-2) as a therapeutic target has led to a paradigm shift in acute myeloid leukemia (AML) treatment. Pyroptosis is a novel antitumor therapeutic mechanism due to its cytotoxic and immunogenic effects. The
Fanghua Ye, Wen Zhang, Chenying Fan, Jiajia Dong, Min Peng, Wenjun Deng, Hui Zhang, Liangchun Yang   +7 more
doaj   +3 more sources

Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis [PDF]

Cellular and Molecular Life Sciences, 2021
AbstractSecondary necrosis has long been perceived as an uncontrolled process resulting in total lysis of the apoptotic cell. Recently, it was shown that progression of apoptosis to secondary necrosis is regulated by Gasdermin E (GSDME), which requires activation by caspase-3.
Elke De Schutter, Jana Ramon, Benjamin Pfeuty, Caroline De Tender, Stephan Stremersch, Koen Raemdonck, Ken Op de Beeck, Wim Declercq, Franck B. Riquet, Kevin Braeckmans, Peter Vandenabeele   +10 more
openalex   +7 more sources

Cleavage-independent GSDME activation by UVC [PDF]

Nature Cell Biology
Erning Zhang, Liam B. Healy, Gang Du, Hao Wu   +3 more
openalex   +2 more sources

Celastrol activates caspase-3/GSDME-dependent pyroptosis in tumor cells by inducing endoplasmic reticulum stress

Journal of Traditional Chinese Medical Sciences
Objective: To investigate the pyroptosis-inducing effects of celastrol on tumor cells and to explore the potential mechanisms involved, specifically focusing on the role of the caspase-3/gasdermin E (GSDME) signaling pathway and the impact of endoplasmic
Jiajian Guo, Dongxiao Cui, Yuping Tang, Sanjiao Wang, Cuiyan Ma, Wenfu Ma   +5 more
doaj   +2 more sources

Pyroptosis‐Inducing Platinum(IV) Prodrugs via GSDME Pathway for Chemoimmunotherapy and Metastasis Inhibition in Triple‐Negative Breast Cancer

Advanced Science
Pyroptosis has attracted significant attention for its role in cancer chemotherapy and immunotherapy. However, few drugs have been reported to induce pyroptosis via the Caspase‐3/gasdermin E (GSDME) pathway.
Xinda Yang, Chuansheng Xu, Youliang Zeng, Chunhui Wang, Yan Gao, Jie Ding, Sirui Chen, Yuheng Pan, Xin Zhang, Zongwan Mao, Shuo Shi   +10 more
doaj   +2 more sources

Mini-Review: GSDME-Mediated Pyroptosis in Diabetic Nephropathy [PDF]

Frontiers in Pharmacology, 2021
Pyroptosis is a recently identified type of lytic programmed cell death, in which pores form in the plasma membrane, and cells swell, rupture, and then release their contents, including inflammatory cytokines. Molecular studies indicated that pyroptosis may occur via a gasdermin D (GSDMD) and caspase-1 (Casp1) -dependent classical pathway, a GSDMD and ...
Wen Li, Jing Sun, Xiaoxi Zhou, Yue Lu, Wenpeng Cui, Lining Miao   +5 more
openaire   +3 more sources

Ocifisertib alleviates the gasdermin D-independent pyroptosis of nucleus pulposus cells by targeting GSDME

Scientific Reports
This study aimed to elucidate the cellular and molecular mechanisms of GSDME in GSDMD independent nucleus pulposus (NP) cell pyroptosis. We analyzed microarray datasets to identify differentially expressed genes (DEGs) in the progression of ...
Yu Lin, Qiyong Chen, Shaoqiang Liu, Boling Liu   +3 more
doaj   +2 more sources