Results 21 to 30 of about 5,144 (202)

Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis [PDF]

Cellular and Molecular Life Sciences, 2021
AbstractSecondary necrosis has long been perceived as an uncontrolled process resulting in total lysis of the apoptotic cell. Recently, it was shown that progression of apoptosis to secondary necrosis is regulated by Gasdermin E (GSDME), which requires activation by caspase-3.
de Schutter, Elke, Ramon, Jana, Pfeuty, Benjamin, de Tender, Caroline, Stremersch, Stephan, Raemdonck, Koen, de Beeck, Ken Op, Declercq, Wim, Riquet, Franck, Braeckmans, Kevin, Vandenabeele, Peter   +10 more
openaire   +6 more sources

Gasdermin-E Mediated Pyroptosis—A Novel Mechanism Regulating Migration, Invasion and Release of Inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-like Synoviocytes

Frontiers in Cell and Developmental Biology, 2022
Synovium fibroblast-like synoviocytes (FLSs) are important participants in the pathogenesis of synovitis and joint destruction in rheumatoid arthritis (RA).
Tao Wu, Xue-Pei Zhang, Qian Zhang, Yao-Yao Zou, Jian-Da Ma, Le-Feng Chen, Yao-Wei Zou, Ji-Meng Xue, Ruo-Fan Ma, Zhong Chen, Lie Dai   +10 more
doaj   +1 more source

Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation

Cell Death and Disease, 2021
Pyroptosis, one kind of inflammatory regulated cell death, is involved in various inflammatory diseases, including acute kidney injury (AKI). Besides Gasdermin D (GSDMD), GSDME is a newly identified mediator of pyroptosis via the cleavage of caspase-3 ...
Weiwei Xia, Yuanyuan Li, Mengying Wu, Qianqian Jin, Qian Wang, Shuzhen Li, Songming Huang, Aihua Zhang, Yue Zhang, Zhanjun Jia   +9 more
doaj   +1 more source

NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils. [PDF]

, 2023
Neutrophil extracellular traps (NETs) not only counteract bacterial and fungal pathogens but can also promote thrombosis, autoimmunity, and sterile inflammation. The presence of citrullinated histones, generated by the peptidylarginine deiminase 4 (PAD4),
Amatullah, Hajera, Askari, Kasra, Catz, Sergio, Chen, Alyce, Croker, Ben, Gerlic, Motti, Ghassemian, Majid, Greco, Kimberly, Griffis, Eric, Hoffman, Hal, Huang, Carolyn, Jeffrey, Kate, Kiosses, William, Lee, Jamie, Nowell, Cameron, Peng, Weiqi, Sadreyev, Ruslan, Salinger, Ari, Santini, Jennifer, Speir, Mary, Tan, ZheHao, Thompson, Paul, Weller, Edie, Wong, Lai, Wu, Gio, Zhu, Yanfang   +25 more
core   +1 more source

GSDME deficiency leads to the aggravation of UVB-induced skin inflammation through enhancing recruitment and activation of neutrophils

Cell Death and Disease, 2022
Gasdermin E (GSDME)-mediated pyroptosis is induced in keratinocytes of UVB-challenged skin. The role of GSDME in UVB-caused skin damage remains unknown. To explore the role of GSDME in UVB-induced skin inflammation.
Yujie Chen, Ni Lian, Sihan Chen, Ta Xiao, Yangying Ke, Yiqun Zhang, Changjun Song, Yong Yang, Song Xu, Heng Gu, Xu Chen   +10 more
doaj   +1 more source

ER stress induces caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with herpes simplex virus type 2 [PDF]

, 2023
Neurotropic viruses, including herpes simplex virus (HSV) types 1 and 2, have the capacity to infect neurons and can cause severe diseases. This is associated with neuronal cell death, which may contribute to morbidity or even mortality if the infection ...
Bak, Rasmus O., Fruhwürth, Stefanie, Gao, Zongliang, Narita, Ryo, Paludan, Søren R., Rashidi, Ahmad S., Reinert, Line S., Ren, Fanghui, Thomsen, Martin K., Verjans, Georges M.G.M.   +9 more
core   +2 more sources

Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn’s disease by promoting intestinal inflammation

Cell Reports, 2021
Summary: Crohn’s disease (CD) is a kind of refractory intestinal inflammatory diseases. Pyroptosis was recently identified as a gasdermin-mediated proinflammatory cell death.
Gao Tan, Chongyang Huang, Jiaye Chen, Bingxia Chen, Fachao Zhi   +4 more
doaj   +1 more source

Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer cells

Cell Communication and Signaling, 2023
Background Lung cancer is the most lethal malignancy, with non-small cell lung cancer (NSCLC) being the most common type (~ 85%). Abnormal activation of epidermal growth factor receptor (EGFR) promotes the development of NSCLC.
Limei Xu, Feifei Shi, Yingdi Wu, Shun Yao, Yingying Wang, Xukai Jiang, Ling Su, Xiangguo Liu   +7 more
doaj   +1 more source

Accelerating functional gene discovery in osteoarthritis. [PDF]

, 2021
Osteoarthritis causes debilitating pain and disability, resulting in a considerable socioeconomic burden, yet no drugs are available that prevent disease onset or progression.
Adams, David J, Adoum, Anne-Tounsia, Bassett, JH Duncan, Bianco, Antonio C, Boyde, Alan, Butterfield, Natalie C, Croucher, Peter I, Curry, Katherine F, Dewhurst, Hannah, Ghirardello, Elena, Jacques, Richard, Komla-Ebri, Davide, Kussy, Fiona, Leitch, Victoria D, Lelliott, Christopher J, Logan, John G, Mannan, Naila S, McAninch, Elizabeth A, Southam, Lorraine, Steinberg, Julia, Vancollie, Valerie E, Waung, Julian A, White, Jacqueline K, Wilkinson, J Mark, Williams, Graham R, Youlten, Scott E, Zeggini, Eleftheria   +26 more
core   +10 more sources

Targeting 7KCh-Induced Cell Death Response Mediated by p38, P2X7 and GSDME in Retinal Pigment Epithelium Cells with Sterculic Acid [PDF]

, 2023
Age-related macular degeneration (AMD) is the main cause of blindness in developed countries. AMD is characterized by the formation of drusen, which are lipidic deposits, between retinal pigment epithelium (RPE) and the choroid. One of the main molecules
0000-0001-9046-6629, 0000-0002-4047-6017, Bobadilla, Miriam, Larráyoz, Ignacio M., Ochoa, Rodrigo, Pariente, Ana, Peláez, Rafael, Pérez-Sala, Álvaro, Villanueva-Martínez, Ángela   +8 more
core   +1 more source