Results 71 to 80 of about 5,144 (202)

Chemotherapy-Activated Caspase 3 Cleaves GSDME to Drive Pyroptosis [PDF]

Cancer Discovery, 2017
Abstract GSMDE promotes a switch of chemotherapy-mediated cell death from apoptosis to pyroptosis.
openaire   +1 more source

Integrating mass spectrometry and systems biology for the modernization of natural medicines: From deciphering chemical complexity to holistic efficacy assessment

VIEW, EarlyView.
This review explores how mass spectrometry is transforming research in natural medicines, with Traditional Chinese medicine (TCM) as a primary exemplar. It details the application of advanced mass spectrometry in chemical analysis, the development of comprehensive quality control methods, and systematic research on the targeted mechanisms of single ...
Yudian Xu, Linlin Cao, Chenhuan Ding, Chen Wang, Yi Lai, Dan Ru, He Li, Wei Xu   +7 more
wiley   +1 more source

Gasdermin E Deletion Attenuates Ureteral Obstruction- and 5/6 Nephrectomy-Induced Renal Fibrosis and Kidney Dysfunction

Frontiers in Cell and Developmental Biology, 2021
Renal fibrosis contributes to kidney dysfunction in various chronic kidney diseases (CKDs). Renal fibrosis can be driven by renal tubular cell death and inflammation.
Mengying Wu, Mengying Wu, Mengying Wu, Weiwei Xia, Weiwei Xia, Weiwei Xia, Qianqian Jin, Qianqian Jin, Qianqian Jin, Anning Zhou, Anning Zhou, Anning Zhou, Qian Wang, Qian Wang, Qian Wang, Shuzhen Li, Shuzhen Li, Shuzhen Li, Songming Huang, Songming Huang, Songming Huang, Aihua Zhang, Aihua Zhang, Aihua Zhang, Yue Zhang, Yue Zhang, Yue Zhang, Yuanyuan Li, Yuanyuan Li, Yuanyuan Li, Zhanjun Jia, Zhanjun Jia, Zhanjun Jia   +32 more
doaj   +1 more source

Investigating the role of Schizophrenia-associated gene expression in the developing human brain using Machine Learning [PDF]

, 2021
Schizophrenia is a debilitating condition that affects 1% of the population, causes significant hardship and though there are treatments available they are characterised by several limitations.
Kelly, Katie
core   +4 more sources

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source

Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P

Cell Research, 2023
AbstractPyroptosis is a type of regulated cell death executed by gasdermin family members. However, how gasdermin-mediated pyroptosis is negatively regulated remains unclear. Here, we demonstrate that mannose, a hexose, inhibits GSDME-mediated pyroptosis by activating AMP-activated protein kinase (AMPK).
Yuan-li Ai, Wei-jia Wang, Fan-jian Liu, Wei Fang, Hang-zi Chen, Liu-zheng Wu, Xuehui Hong, Yuekun Zhu, Ci-xiong Zhang, Long-yu Liu, Wen-bin Hong, Bo Zhou, Qi-tao Chen, Qiao Wu   +13 more
openaire   +2 more sources

An anti-mesothelin targeting antibody drug conjugate induces pyroptosis and ignites antitumor immunity in mouse models of cancer

Journal for ImmunoTherapy of Cancer, 2023
Background Emerging evidence suggests that the mechanism of chemotherapy-induced cell death may influence the antitumor immune response in patients with cancer.
Michael P Brown, Nicole L Wittwer, Alexander H Staudacher, Vasilios Liapis, Pina Cardarelli, Harriet Warren   +5 more
doaj   +1 more source

Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders

MedComm, Volume 7, Issue 4, April 2026.
CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley   +1 more source

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8 [PDF]

, 2020
Necroptosis and pyroptosis are inflammatory forms of regulated necrotic cell death as opposed to apoptosis that is generally considered immunologically silent.
Laurien, Lucie, Pasparakis, Manolis, Schwarzer, Robin   +2 more
core   +1 more source