Results 71 to 80 of about 6,248 (265)

BIX‐01294 enhanced chemotherapy effect in gastric cancer by inducing GSDME‐mediated pyroptosis [PDF]

Cell Biology International, 2020
AbstractAdjuvant chemotherapy in combination with surgery is expected to be a curative strategy for gastric cancer. However, drug resistance remains an obstacle in effective chemotherapy. Therefore, understanding the potential mechanisms of chemotherapy induced gastric cancer cell death is of great importance.
Bei‐Bei Deng, Bao‐Ping Jiao, Yang‐Jun Liu, Yan‐Rong Li, Gui‐Jun Wang   +4 more
openaire   +2 more sources

Pyroptosis in Neutrophils: Multimodal Integration of Inflammasome and Regulated Cell Death Signaling Pathways [PDF]

, 2023
Pyroptosis is a proinflammatory mode of lytic cell death mediated by accumulation of plasma membrane (PM) macropores composed of gasdermin-family (GSDM) proteins.
Dubyak, George R, Miller, Brandon A, Pearlman, Eric   +2 more
core   +1 more source

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, EarlyView.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source

Transcriptomic insights into GSDME-driven pyroptosis in head and neck cancer. [PDF]

Sci Rep
This study investigates the expression of pyroptosis-related genes (PRGs) in head and neck squamous cell carcinoma (HNSCC) and their potential role in the tumor immune microenvironment.
Hao F, Qin D, Li R, Li X, Hou J, Zhao B.
europepmc   +2 more sources

Gasdermins in Apoptosis: New players in an Old Game. [PDF]

, 2019
Apoptosis is a form of programmed cell death (PCD) that plays critical physiological roles in removing superfluous or dangerous cell populations that are unneeded or threatening to the health of the host organism.
Alnemri, Emad S., Rogers, Corey
core   +1 more source

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

Biomimetic dual-crosslinked GelMA-SilMA hydrogel microneedle for delivering DSPE-PEG2K-TAT-modified quercetin liposomes to treat rheumatoid arthritis via the caspase-8/caspase-3/GSDME pathway. [PDF]

J Nanobiotechnology
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovitis, whose pathogenesis remains unclear. Fibroblast-like synoviocytes (FLS) are central to the pathogenesis and progression of RA. This study aims to investigate the novel
Zheng Q, Lin R, Chen R, Xu W.
europepmc   +2 more sources

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

Cardiomyocyte GSDME Drives Doxorubicin-Induced Cardiotoxicity by Targeting the CCL2-CCR2 Axis. [PDF]

Int J Biol Sci
The use of doxorubicin (DOX), a wide-spectrum antineoplastic drug, is largely limited in clinical practice because of the less than satisfactory strategies available for the prevention and treatment of doxorubicin-induced cardiotoxicity (DIC).
Xue J, Xie S, Cheng X, Su E, Song X, Wei L, Yu P, Liu M, Jiang H.   +8 more
europepmc   +2 more sources

Jefferson Digital Commons quarterly report: April-June 2019 [PDF]

, 2018
This quarterly report includes: Articles CREATE Day Presentations Dissertations From the Archives Grand Rounds and Lectures House Staff Quality Improvement and Patient Safety Posters JCIPE Student Hotspotting Posters Journals and Newsletters MPH ...
Copeland, LIBT, James, Duinkerken, MSI, Kelsey   +1 more
core   +2 more sources