Results 81 to 90 of about 6,248 (265)

Biomimetic Iridium‐Based Photothermal Nanozyme to Trigger Ferroptosis and Pyroptosis and Activate the cGAS‐STING Pathway for Improved Tumor Immunotherapy

Advanced Science, EarlyView.
This study develops an iridium‐based nanozyme (IIN@M) with superior enzyme‐like activity and photothermal performance. It disrupts intracellular redox balance by generating reactive oxygen species and depleting glutathione, which synergistically induces ferroptosis, pyroptosis, and immunogenic cell death.
Lijun Ding, Zhongxiong Fan, Guoyu Xia, Fukai Zhu, Nan Yang, Shujie Yu, Longlong Yuan, Jinyao Li   +7 more
wiley   +1 more source

Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation

Cell Death and Disease
Gasdermin E (GSDME) has recently been identified as a critical executioner to mediate pyroptosis. While epidermal keratinocytes can initiate GSDME-mediated pyroptosis, the role of keratinocyte GSDME in psoriatic dermatitis remains poorly characterized ...
Fangyuan Long, Xuecui Wei, Yujie Chen, Min Li, Ni Lian, Shanshan Yu, Sihan Chen, Yong Yang, Min Li, Heng Gu, Xu Chen   +10 more
doaj   +1 more source

Expression levels of caspase‐3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer

Cancer Reports, 2022
Background Pyroptosis plays a dual role in the development of cancer and malignancy; as such, it may potentially be a new target for cancer treatment. However, the inflammatory response to pyroptosis may have adverse effects on the body.
Yuan‐Li Huang, Guang‐Hui Zhang, Qing Zhu, Xia Wu, Li‐Gao Wu   +4 more
doaj   +1 more source

Mitochondria-targeted photodynamic therapy triggers GSDME-mediated pyroptosis and sensitizes anti-PD-1 therapy in colorectal cancer

Journal for ImmunoTherapy of Cancer
Background The effectiveness of immune checkpoint inhibitors in colorectal cancer (CRC) is limited due to the low tumor neoantigen load and low immune infiltration in most microsatellite-stable (MSS) tumors.
Yun Zhou, Wenyao Zhang, Boda Wang, Pei Wang, Dan Li, Tianyu Cao, Dawei Zhang, Hua Han, Mingfeng Bai, Xin Wang, Xiaodi Zhao, Yuanyuan Lu   +11 more
semanticscholar   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Investigating the role of Schizophrenia-associated gene expression in the developing human brain using Machine Learning [PDF]

, 2021
Schizophrenia is a debilitating condition that affects 1% of the population, causes significant hardship and though there are treatments available they are characterised by several limitations.
Kelly, Katie
core   +4 more sources

Methylcobalamin protects against liver failure via engaging gasdermin E

Nature Communications
Gasdermin E (GSDME) is a pyroptotic cell death effector and a promising target for pyroptotic tissue injury. Here we perform high-throughput screening and demonstrate that methylcobalamin (MeCbl), an endogenous coenzyme form of vitamin B12, is a specific
Wanfeng Xu, Yun Wang, Shuang Cui, Qiuling Zheng, Yanghao Lin, Qingqing Cui, Yuxin Xie, Yuming Zeng, Chuan Zhang, Yujie Li, Xin Jin, Minna Qin, Huiyong Sun, Haiping Hao, Lijuan Cao   +14 more
doaj   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Gasdermin E Deletion Attenuates Ureteral Obstruction- and 5/6 Nephrectomy-Induced Renal Fibrosis and Kidney Dysfunction

Frontiers in Cell and Developmental Biology, 2021
Renal fibrosis contributes to kidney dysfunction in various chronic kidney diseases (CKDs). Renal fibrosis can be driven by renal tubular cell death and inflammation.
Mengying Wu, Mengying Wu, Mengying Wu, Weiwei Xia, Weiwei Xia, Weiwei Xia, Qianqian Jin, Qianqian Jin, Qianqian Jin, Anning Zhou, Anning Zhou, Anning Zhou, Qian Wang, Qian Wang, Qian Wang, Shuzhen Li, Shuzhen Li, Shuzhen Li, Songming Huang, Songming Huang, Songming Huang, Aihua Zhang, Aihua Zhang, Aihua Zhang, Yue Zhang, Yue Zhang, Yue Zhang, Yuanyuan Li, Yuanyuan Li, Yuanyuan Li, Zhanjun Jia, Zhanjun Jia, Zhanjun Jia   +32 more
doaj   +1 more source

Metformin Inhibited GSDME to Suppress M2 Macrophage Pyroptosis and Maintain M2 Phenotype to Mitigate Cisplatin-Induced Intestinal Inflammation

Biomedicines
Background: The continuous clinical use of cisplatin is prevented by gastrointestinal toxicity. Methods: Cisplatin was used to treat THP-1-derived macrophages to see its differential effects on different subtypes of macrophages.
Ke Jiang, Qi He, Chenhui Wang, Wen Yang, Changdong Zhou, Jian Li, Jiangbo Li, Yuke Cui, Jingqi Shi, Zhenqiao Wei, Yuanyuan Jiao, Ligai Bai, Shengqi Wang, Liang Guo   +13 more
doaj   +1 more source