Results 21 to 30 of about 35,497 (235)

Potential Regulatory Role of miR-21 on Alzheimer’s Disease by Targeting GSK-3β Signaling

Galen Medical Journal, 2023
Background: Alzheimer’s disease (AD) is the most important neurogenerative disorder with progressive dementia as its main clinical manifestation. The microRNAs (miRNAs) are identified as crucial modulators in AD progression. Nevertheless, the biological potential of miR-21 in AD is obscure. Hence, this study aimed to evaluate the possible role of miR-
openaire   +2 more sources

Beraprost sodium attenuates the development of myocardial fibrosis after myocardial infarction by regulating GSK‐3β expression in rats

Immunity, Inflammation and Disease, 2023
Objective The aim of this study was to elucidate the mechanism of beraprost sodium (BPS) in the intervention of myocardial fibrosis after myocardial infarction (MI) through glycogen synthase kinase‐3β (GSK‐3β) and to provide new ideas for intervention in
Xing‐Xing Li, Yun‐Zhe Wang, Chuang Liu, Guo‐Wei Fu, Jun Li, Jin‐Ying Zhang   +5 more
doaj   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

Regulatory Role of GSK-3β on NF-κB, Nitric Oxide, and TNF-α in Group A Streptococcal Infection

Mediators of Inflammation, 2013
Group A streptococcus (GAS) imposes a great burden on humans. Efforts to minimize the associated morbidity and mortality represent a critical issue. Glycogen synthase kinase-3β (GSK-3β) is known to regulate inflammatory response in infectious diseases ...
Yu-Tzu Chang, Chia-Ling Chen, Chiou-Feng Lin, Shiou-Ling Lu, Miao-Huei Cheng, Chih-Feng Kuo, Yee-Shin Lin   +6 more
doaj   +1 more source

Additional file 7: of GSK-3β protects fetal oocytes from premature death via modulating TAp63 expression in mice

, 2019
Table S3. Antibody information. (DOCX 13 kb)
Wen, Jia, Yan, Hao, He, Meina, Zhang, Tuo, Xinyi Mu, Haibin Wang, Zhang, Hua, Guoliang Xia, Wang, Chao   +8 more
openaire   +1 more source

Molecular docking study of xylogranatins binding to glycogen synthase kinase-3β

Digital Chinese Medicine, 2022
Objective: The mangrove tree Xylocarpus granatum J. Koenig (X. granatum) is a medicinal plant used to treat various diseases in several Asian countries.
Christian Bailly, Gérard Vergoten
doaj   +1 more source

Additional file 5: of GSK-3β protects fetal oocytes from premature death via modulating TAp63 expression in mice

, 2019
Table S1. Genotyping primers. (DOCX 11 kb)
Wen, Jia, Yan, Hao, He, Meina, Zhang, Tuo, Xinyi Mu, Haibin Wang, Zhang, Hua, Guoliang Xia, Wang, Chao   +8 more
openaire   +1 more source

Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: Role of GSK-3β in Myocardial Protection Against Ischemia/Reperfusion Injury

Journal of Pharmacological Sciences, 2009
Although reperfusion is required to salvage ischemic myocardium from necrosis, reperfusion per se induces myocardial necrosis. In this “lethal reperfusion injury”, opening of the mitochondrial permeability transition pore (mPTP) upon reperfusion is ...
Tetsuji Miura, Masahiro Nishihara, Takayuki Miki   +2 more
doaj   +1 more source

Glycogen Synthase Kinase-3β Facilitates Cytokine Production in 12-O-Tetradecanoylphorbol-13-Acetate/Ionomycin-Activated Human CD4⁺ T Lymphocytes

Cells, 2020
Cytokines are the major immune regulators secreted from activated CD4+ T lymphocytes that activate adaptive immunity to eradicate nonself cells, including pathogens, tumors, and allografts.
Cheng-Chieh Tsai, Chin-Kun Tsai, Po-Chun Tseng, Chiou-Feng Lin, Chia-Ling Chen   +4 more
doaj   +1 more source