Wheat TaRab7 GTPase is part of the signaling pathway in responses to stripe rust and abiotic stimuli. [PDF]
PLoS ONE, 2012 Small GTP-binding proteins function as regulators of specific intercellular fundamental biological processes. In this study, a small GTP-binding protein Rab7 gene, designated as TaRab7, was identified and characterized from a cDNA library of wheat leaves
Furong Liu +8 more
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Pathogenic single nucleotide polymorphisms in RhoA gene: Insights into structural and functional impacts on RhoA-PLD1 interaction through molecular dynamics simulation [PDF]
Current Research in Structural BiologyMolecular switches serve as key regulators of biological systems by acting as one of the crucial driving forces in the initiation of signal transduction pathway cascades.
Mahbub Hasan +6 more
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Allosteric binding sites in Rab11 for potential drug candidates. [PDF]
PLoS ONE, 2018 Rab11 is an important protein subfamily in the RabGTPase family. These proteins physiologically function as key regulators of intracellular membrane trafficking processes.
Ammu Prasanna Kumar, Suryani Lukman
doaj +1 more source
ARHGEF3 regulates the stability of ACLY to promote the proliferation of lung cancer
Cell Death and Disease, 2022 Rho GTPases play an essential role in many cellular processes, including cell cycle progress, cell motility, invasion, migration, and transformation.
Feifei Zhou +6 more
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Regulation of the Single Polar Flagellar Biogenesis
Biomolecules, 2020 Some bacterial species, such as the marine bacterium Vibrio alginolyticus, have a single polar flagellum that allows it to swim in liquid environments.
Seiji Kojima +2 more
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Quantifying the noise in bursty gene expression under regulation by small RNAs [PDF]
International Journal of Modern Physics C (IJMPC), Vol. 30, No.
07, 1940002 (2019), 2021 Gene expression is a fundamental process in a living system. The small RNAs (sRNAs) is widely observed as a global regulator in gene expression. The inherent nonlinearity in this regulatory process together with the bursty production of messenger RNA (mRNA), sRNA and protein make the exact solution for this stochastic process intractable.
arxiv +1 more source
Membranes, 2021 Oxytocin (OT) and its receptor (OTR) are expressed in the heart and are involved in the physiological cardiovascular functional system. Although it is known that OT/OTR signaling is cardioprotective by reducing the inflammatory response and improving ...
Masaki Morishima +3 more
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Analyzing and Comparing Omicron Lineage Variants Protein-Protein Interaction Network using Centrality Measure [PDF]
SN Computer Science.4(2023)299, 2023 The Worldwide spread of the Omicron lineage variants has now been confirmed. It is crucial to understand the process of cellular life and to discover new drugs need to identify the important proteins in a protein interaction network (PPIN). PPINs are often represented by graphs in bioinformatics, which describe cell processes.
arxiv +1 more source
PLoS ONE, 2022 Small RHO-type G-proteins act as signaling hubs and master regulators of polarity in eukaryotic cells. Their activity is tightly controlled, as defective RHO signaling leads to aberrant growth and developmental defects.
Lukas Weiß +10 more
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Rho GTPases as Key Molecular Players within Intestinal Mucosa and GI Diseases
Cells, 2021 Rho proteins operate as key regulators of the cytoskeleton, cell morphology and trafficking. Acting as molecular switches, the function of Rho GTPases is determined by guanosine triphosphate (GTP)/guanosine diphosphate (GDP) exchange and their lipidation
Rashmita Pradhan +4 more
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