Results 1 to 10 of about 81,080 (190)

Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins

Computational and Structural Biotechnology Journal, 2021
Ras undergoes interconversion between the active GTP-bound state and the inactive GDP-bound state. This GTPase cycle, which controls the activities of Ras, is accelerated by Ras GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors ...
Yuanhao Wang, Dong Ji, Chaoyu Lei, Yingfei Chen, Yuran Qiu, Xinyi Li, Mingyu Li, Duan Ni, Jun Pu, Jian Zhang, Qiang Fu, Yaqin Liu, Shaoyong Lu   +12 more
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Wheat TaRab7 GTPase is part of the signaling pathway in responses to stripe rust and abiotic stimuli. [PDF]

PLoS ONE, 2012
Small GTP-binding proteins function as regulators of specific intercellular fundamental biological processes. In this study, a small GTP-binding protein Rab7 gene, designated as TaRab7, was identified and characterized from a cDNA library of wheat leaves
Furong Liu, Jun Guo, Pengfei Bai, Yinhui Duan, Xiaodong Wang, Yulin Cheng, Hao Feng, Lili Huang, Zhensheng Kang   +8 more
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Regulation of the Single Polar Flagellar Biogenesis

Biomolecules, 2020
Some bacterial species, such as the marine bacterium Vibrio alginolyticus, have a single polar flagellum that allows it to swim in liquid environments.
Seiji Kojima, Hiroyuki Terashima, Michio Homma   +2 more
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ARHGEF3 regulates the stability of ACLY to promote the proliferation of lung cancer

Cell Death and Disease, 2022
Rho GTPases play an essential role in many cellular processes, including cell cycle progress, cell motility, invasion, migration, and transformation.
Feifei Zhou, Wenqian Ai, Yixing Zhang, Qifan Hu, Mingxi Gan, Jian-Bin Wang, Tianyu Han   +6 more
doaj   +1 more source

Regulation of lymphocyte-mediated killing by GTP-binding proteins [PDF]

Journal of Leukocyte Biology, 2003
Abstract Exocytosis of granules containing apoptosis-inducing proteins is one mechanism of target cell killing by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Granules containing perforin and granzymes are redistributed to the area of cell contact initiated by specific interactions between surface ligands on a target ...
Dianne, Khurana, Paul J, Leibson
openaire   +2 more sources

Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics [PDF]

Scientific Reports, 2017
AbstractThe mitotic spindle, essential for segregating the sister chromatids into the two evolving daughter cells, is composed of highly dynamic cytoskeletal filaments, the microtubules. The dynamics of microtubules are regulated by numerous microtubule associated proteins.
Schellhaus, A.K., Moreno-Andrés, D., Chugh, M., Yokoyama, H., Moschopoulou, A., De, S., Bono, F., Hipp, K., Schäffer, E., Antonin, W.   +9 more
openaire   +7 more sources

Posttranslational modification of the RHO of plants protein RACB by phosphorylation and cross-kingdom conserved ubiquitination.

PLoS ONE, 2022
Small RHO-type G-proteins act as signaling hubs and master regulators of polarity in eukaryotic cells. Their activity is tightly controlled, as defective RHO signaling leads to aberrant growth and developmental defects.
Lukas Weiß, Lana Gaelings, Tina Reiner, Julia Mergner, Bernhard Kuster, Attila Fehér, Götz Hensel, Manfred Gahrtz, Jochen Kumlehn, Stefan Engelhardt, Ralph Hückelhoven   +10 more
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Oxytocin Downregulates the Ca_V1.2 L-Type Ca²⁺ Channel via Gi/cAMP/PKA/CREB Signaling Pathway in Cardiomyocytes

Membranes, 2021
Oxytocin (OT) and its receptor (OTR) are expressed in the heart and are involved in the physiological cardiovascular functional system. Although it is known that OT/OTR signaling is cardioprotective by reducing the inflammatory response and improving ...
Masaki Morishima, Shintaro Tahara, Yan Wang, Katsushige Ono   +3 more
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Rho GTPases as Key Molecular Players within Intestinal Mucosa and GI Diseases

Cells, 2021
Rho proteins operate as key regulators of the cytoskeleton, cell morphology and trafficking. Acting as molecular switches, the function of Rho GTPases is determined by guanosine triphosphate (GTP)/guanosine diphosphate (GDP) exchange and their lipidation
Rashmita Pradhan, Phuong A. Ngo, Luz d. C. Martínez-Sánchez, Markus F. Neurath, Rocío López-Posadas   +4 more
doaj   +1 more source

Computational study of the motor neuron protein KIF5A to identify nsSNPs, bioactive compounds, and its key regulators

Frontiers in Genetics, 2023
Introduction: Kinesin family member 5A (KIF5A) is a motor neuron protein expressed in neurons and involved in anterograde transportation of organelles, proteins, and RNA. Variations in the KIF5A gene that interfere with axonal transport have emerged as a
Rupesh Kumar, Thirumurthy Madhavan, Kalaiarasan Ponnusamy, Honglae Sohn, Shazia Haider   +4 more
doaj   +1 more source