Results 1 to 10 of about 40,011 (267)
Oncogene ect2 is related to regulators of small GTP-binding proteins [PDF]
Nature, 1993 We have developed an efficient expression cloning system that allows rapid isolation of complementary DNAs able to induce the transformed phenotype. We searched for molecules expressed in epithelial cells and possessing transforming potential to fibroblasts, and cloned a cDNA for the normal receptor of a growth factor secreted by NIH/3T3 cells. Here we
Toru Miki +4 more
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Computational and Structural Biotechnology Journal, 2021 Ras undergoes interconversion between the active GTP-bound state and the inactive GDP-bound state. This GTPase cycle, which controls the activities of Ras, is accelerated by Ras GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors ...
Yuanhao Wang +12 more
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Wheat TaRab7 GTPase is part of the signaling pathway in responses to stripe rust and abiotic stimuli. [PDF]
PLoS ONE, 2012 Small GTP-binding proteins function as regulators of specific intercellular fundamental biological processes. In this study, a small GTP-binding protein Rab7 gene, designated as TaRab7, was identified and characterized from a cDNA library of wheat leaves
Furong Liu +8 more
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Allosteric binding sites in Rab11 for potential drug candidates. [PDF]
PLoS ONE, 2018 Rab11 is an important protein subfamily in the RabGTPase family. These proteins physiologically function as key regulators of intracellular membrane trafficking processes.
Ammu Prasanna Kumar, Suryani Lukman
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Regulation of the Single Polar Flagellar Biogenesis
Biomolecules, 2020 Some bacterial species, such as the marine bacterium Vibrio alginolyticus, have a single polar flagellum that allows it to swim in liquid environments.
Seiji Kojima +2 more
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ARHGEF3 regulates the stability of ACLY to promote the proliferation of lung cancer
Cell Death and Disease, 2022 Rho GTPases play an essential role in many cellular processes, including cell cycle progress, cell motility, invasion, migration, and transformation.
Feifei Zhou +6 more
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Regulation of lymphocyte-mediated killing by GTP-binding proteins [PDF]
Journal of Leukocyte Biology, 2003 Abstract Exocytosis of granules containing apoptosis-inducing proteins is one mechanism of target cell killing by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Granules containing perforin and granzymes are redistributed to the area of cell contact initiated by specific interactions between surface ligands on a target ...
Dianne, Khurana, Paul J, Leibson
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Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics [PDF]
Scientific Reports, 2017 AbstractThe mitotic spindle, essential for segregating the sister chromatids into the two evolving daughter cells, is composed of highly dynamic cytoskeletal filaments, the microtubules. The dynamics of microtubules are regulated by numerous microtubule associated proteins.
Schellhaus, A.K. +9 more
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PLoS ONE, 2022 Small RHO-type G-proteins act as signaling hubs and master regulators of polarity in eukaryotic cells. Their activity is tightly controlled, as defective RHO signaling leads to aberrant growth and developmental defects.
Lukas Weiß +10 more
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Membranes, 2021 Oxytocin (OT) and its receptor (OTR) are expressed in the heart and are involved in the physiological cardiovascular functional system. Although it is known that OT/OTR signaling is cardioprotective by reducing the inflammatory response and improving ...
Masaki Morishima +3 more
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