Results 11 to 20 of about 168,029 (341)
Regulation of lymphocyte-mediated killing by GTP-binding proteins [PDF]
Journal of Leukocyte Biology, 2003 Abstract Exocytosis of granules containing apoptosis-inducing proteins is one mechanism of target cell killing by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Granules containing perforin and granzymes are redistributed to the area of cell contact initiated by specific interactions between surface ligands on a target ...
Dianne, Khurana, Paul J, Leibson
openaire +2 more sources
Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics [PDF]
Scientific Reports, 2017 AbstractThe mitotic spindle, essential for segregating the sister chromatids into the two evolving daughter cells, is composed of highly dynamic cytoskeletal filaments, the microtubules. The dynamics of microtubules are regulated by numerous microtubule associated proteins.
Schellhaus, A.K. +9 more
openaire +7 more sources
PLoS ONE, 2022 Small RHO-type G-proteins act as signaling hubs and master regulators of polarity in eukaryotic cells. Their activity is tightly controlled, as defective RHO signaling leads to aberrant growth and developmental defects.
Lukas Weiß +10 more
doaj +1 more source
Membranes, 2021 Oxytocin (OT) and its receptor (OTR) are expressed in the heart and are involved in the physiological cardiovascular functional system. Although it is known that OT/OTR signaling is cardioprotective by reducing the inflammatory response and improving ...
Masaki Morishima +3 more
doaj +1 more source
Rho GTPases as Key Molecular Players within Intestinal Mucosa and GI Diseases
Cells, 2021 Rho proteins operate as key regulators of the cytoskeleton, cell morphology and trafficking. Acting as molecular switches, the function of Rho GTPases is determined by guanosine triphosphate (GTP)/guanosine diphosphate (GDP) exchange and their lipidation
Rashmita Pradhan +4 more
doaj +1 more source
Frontiers in Genetics, 2023 Introduction: Kinesin family member 5A (KIF5A) is a motor neuron protein expressed in neurons and involved in anterograde transportation of organelles, proteins, and RNA. Variations in the KIF5A gene that interfere with axonal transport have emerged as a
Rupesh Kumar +4 more
doaj +1 more source
Frontiers in Plant Science, 2022 Stem cutting recalcitrance to adventitious root formation is a major limitation for the clonal propagation or micropropagation of elite genotypes of many forest tree species, especially at the adult stage of development.
Alberto Pizarro, Carmen Díaz-Sala
doaj +1 more source
GTP-Binding Proteins and Regulated Exocytosis [PDF]
Critical Reviews in Oral Biology & Medicine, 1999 Regulated exocytosis, which occurs in response to stimuli, is a two-step process involving the docking of secretory granules (SGs) at specific sites on the plasma membrane (PM), with subsequent fusion and release of granule contents. This process plays a crucial role in a number of tissues, including exocrine glands, chromaffin cells, platelets, and ...
openaire +2 more sources
Dual positive and negative regulation of GPCR signaling by GTP hydrolysis [PDF]
, 2009 G protein-coupled receptors (GPCRs) regulate a variety of intracellular pathways through their ability to promote the binding of GTP to heterotrimeric G proteins. Regulator of G protein signaling (RGS) proteins increase the intrinsic GTPase activity of G-
Berg, Hugo van den +8 more
core +1 more source
The non-catalytic carboxyl-terminal domain of ARFGAP1 regulates actin cytoskeleton reorganization by antagonizing the activation of Rac1. [PDF]
PLoS ONE, 2011 The regulation of the actin cytoskeleton and membrane trafficking is coordinated in mammalian cells. One of the regulators of membrane traffic, the small GTP-binding protein ARF1, also activates phosphatidylinositol kinases that in turn affect actin ...
Ka Yu Siu +6 more
doaj +1 more source