Results 21 to 30 of about 82,021 (288)

Regulators of G protein signalling proteins in the human myometrium [PDF]

, 2009
The contractile state of the human myometrium is controlled by extracellular signals that promote relaxation or contraction. Many of these signals function through G proteincoupled receptors at the cell surface, stimulating heterotrimeric G proteins and ...
Abramow-Newerly, Ballon, Bansal, Benians, Bernstein, Blanks, Brodt-Eppley, Chatterjee, Cho, De Vries, Dohlman, Druey, Europe-Finner, Georgoussi, Graham Ladds, Hague, Hao, Hepler, Hill, Hollinger, Hu, John Davey, Koelle, Ladds, Langer, Li, Lopez-Bernal, Manu Vatish, Milligan, Mittmann, Moore, Neitzel, O'Brien, Park, Phaneuf, Plested, Ross, Saitoh, Sanborn, Sevasti Zervou, Snabaitis, Snow, Steven Thornton, Suarez, Tamirisa, Tang, Tinker, Tribe, Wang, Willars, Xie, Xu, Zeng   +52 more
core   +1 more source

Novel split-luciferase-based genetically encoded biosensors for noninvasive visualization of Rho GTPases. [PDF]

PLoS ONE, 2013
Rho family GTPases are critical regulators of many important cellular processes and the dysregulation of their activities is implicated in a variety of human diseases including oncogenesis and propagation of malignancy.
Weibing Leng, Xiaohui Pang, Hongwei Xia, Mingxing Li, Liu Chen, Qiulin Tang, Dandan Yuan, Ronghui Li, Libo Li, Fabao Gao, Feng Bi   +10 more
doaj   +1 more source

Regulation of polarised growth in fungi [PDF]

, 2008
Polarised growth in fungi occurs through the delivery of secretory vesicles along tracks formed by cytoskeletal elements to specific sites on the cell surface where they dock with a multiprotein structure called the exocyst before fusing with the ...
Adamo, Adamo, Adams, Akashi, Ayad-Durieux, Bachewich, Bartnicki-Garcia, Bartnicki-Garcia, Bassilana, Bassilana, Bassilana, Behrens, Berman, Bidlingmaier, Bose, Boyce, Boyce, Boyce, Boyd, Brown, Caviston, Chant, Chapa y Lazo, Collinge, Colman-Lerner, Court, Crampin, Cvrckova, Dong, Drgonova, Dunkler, Feng, Finger, France, Gao, Girbardt, Gladfelter, Goehring, Gorovits, Gulli, Guo, Harris, Harris, Hartwell, Hergovich, Hou, Hou, Irazoqui, Jin, Karnoub, Knechtle, Kohno, Konzack, Kron, Leberer, Leberer, Leberer, Leonhard, Lew, Li, Liu, Loeb, Loeb, Longtine, Mahlert, Mata, McCollum, McCusker, Medkova, Mehta, Mendenhall, Nelson, Nonaka, Novick, Pan, Park, Pearson, Peter, Peter E. Sudbery, Philippsen, Punt, Qadota, Racki, Read, Santangelo, Schmidt, Seiler, Seiler, Sinha, Smith, Soll, Stevenson, Sudbery, Sudbery, Sudbery, Tamaskovic, Tanaka, Tcheperegine, Trinci, Verde, Versele, Virag, Virag, Walton, Walworth, Wedlich-Soldner, Wedlich-Soldner, Wendland, Wu, Yarden, Zhang, Zheng, Zheng   +112 more
core   +1 more source

Structural determinants at the M2 muscarinic receptor modulate the RGS4-GIRK response to pilocarpine by impairment of the receptor voltage sensitivity. [PDF]

, 2017
Membrane potential controls the response of the M2 muscarinic receptor to its ligands. Membrane hyperpolarization increases response to the full agonist acetylcholine (ACh) while decreasing response to the partial agonist pilocarpine.
Chen, I-Shan, Furutani, Kazuharu, Kurachi, Yoshihisa   +2 more
core   +1 more source

Allosteric binding sites in Rab11 for potential drug candidates.

PLoS ONE, 2018
Rab11 is an important protein subfamily in the RabGTPase family. These proteins physiologically function as key regulators of intracellular membrane trafficking processes.
Ammu Prasanna Kumar, Suryani Lukman
doaj   +1 more source

Function and regulation of Rnd proteins in cortical projection neuron migration

Frontiers in Neuroscience, 2015
The mammalian cerebral cortex contains a high variety of neuronal subtypes that acquire precise spatial locations and form long or short-range connections to establish functional neuronal circuits.
Roberta eAzzarelli, Francois eGuillemot, Emilie ePacary, Emilie ePacary   +3 more
doaj   +1 more source

High throughput transcriptome profiling of lithium stimulated human mesenchymal stem cells reveals priming towards osteoblastic lineage. [PDF]

PLoS ONE, 2013
Human mesenchymal stem cells (hMSCs) present in the bone marrow are the precursors of osteoblasts, chondrocytes and adipocytes, and hold tremendous potential for osteoregenerative therapy.
Neeraj Kumar Satija, Deepa Sharma, Farhat Afrin, Rajendra P Tripathi, Gurudutta Gangenahalli   +4 more
doaj   +1 more source

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton [PDF]

The EMBO Journal, 1999
Soluble factors from serum such as lysophosphatidic acid (LPA) are thought to activate the small GTP-binding protein Rho based on their ability to induce actin stress fibers and focal adhesions in a Rho-dependent manner. Cell adhesion to extracellular matrices (ECM) has also been proposed to activate Rho, but this point has been controversial due to ...
X D, Ren, W B, Kiosses, M A, Schwartz
openaire   +2 more sources

Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac. [PDF]

PLoS ONE, 2010
The intracellular bacterium Chlamydia trachomatis causes infections of urogenital tract, eyes or lungs. Alignment reveals homology of CT166, a putative effector protein of urogenital C. trachomatis serovars, with the N-terminal glucosyltransferase domain
Jessica Thalmann, Katrin Janik, Martin May, Kirsten Sommer, Jenny Ebeling, Fred Hofmann, Harald Genth, Andreas Klos   +7 more
doaj   +1 more source

The small GTP-binding protein Rac is a regulator of cell death in plants [PDF]

Proceedings of the National Academy of Sciences, 1999
Cell death plays important roles in the development and defense of plants as in other multicellular organisms. Rapid production of reactive oxygen species often is associated with plant defense against pathogens, but their molecular mechanisms are not known.
T, Kawasaki, K, Henmi, E, Ono, S, Hatakeyama, M, Iwano, H, Satoh, K, Shimamoto   +6 more
openaire   +2 more sources