Results 21 to 30 of about 41,822 (243)
High throughput transcriptome profiling of lithium stimulated human mesenchymal stem cells reveals priming towards osteoblastic lineage. [PDF]
PLoS ONE, 2013 Human mesenchymal stem cells (hMSCs) present in the bone marrow are the precursors of osteoblasts, chondrocytes and adipocytes, and hold tremendous potential for osteoregenerative therapy.
Neeraj Kumar Satija +4 more
doaj +1 more source
Regulation of the small GTP‐binding protein Rho by cell adhesion and the cytoskeleton [PDF]
The EMBO Journal, 1999 Soluble factors from serum such as lysophosphatidic acid (LPA) are thought to activate the small GTP-binding protein Rho based on their ability to induce actin stress fibers and focal adhesions in a Rho-dependent manner. Cell adhesion to extracellular matrices (ECM) has also been proposed to activate Rho, but this point has been controversial due to ...
X D, Ren, W B, Kiosses, M A, Schwartz
openaire +2 more sources
Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac. [PDF]
PLoS ONE, 2010 The intracellular bacterium Chlamydia trachomatis causes infections of urogenital tract, eyes or lungs. Alignment reveals homology of CT166, a putative effector protein of urogenital C. trachomatis serovars, with the N-terminal glucosyltransferase domain
Jessica Thalmann +7 more
doaj +1 more source
The small GTP-binding protein Rac is a regulator of cell death in plants [PDF]
Proceedings of the National Academy of Sciences, 1999 Cell death plays important roles in the development and defense of plants as in other multicellular organisms. Rapid production of reactive oxygen species often is associated with plant defense against pathogens, but their molecular mechanisms are not known.
T, Kawasaki +6 more
openaire +2 more sources
Differential proteome analysis of pea roots at the early stages of symbiosis with nodule bacteria
Вавиловский журнал генетики и селекции, 2018 In this paper, we have analyzed changes in the proteomic spectrum of pea Pisum sativum L. roots during inoculation with rhizobial bacteria with the aim of revealing new regulators of symbiosis development. To study the changes in the proteome spectrum of
I. V. Leppyanen +3 more
doaj +1 more source
Small GTP-binding protein Ran is regulated by posttranslational lysine acetylation [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance The small GTPase Ran plays fundamental roles in cellular processes such as nucleo-cytoplasmic transport, mitotic spindle formation, and nuclear envelope assembly. Recently, Ran was found to be lysine acetylated, among others, in functionally important regions such as switch I and switch II.
Susanne, de Boor +9 more
openaire +2 more sources
PLoS ONE, 2019 Regulators of G Protein Signaling (RGS proteins) inhibit G protein-coupled receptor (GPCR) signaling by accelerating the GTP hydrolysis rate of activated Gα subunits.
Adam B Schroer +5 more
doaj +1 more source
Phytochrome regulates GTP‐binding protein activity in the envelope of pea nuclei [PDF]
The Plant Journal, 1993 Three GTP‐binding proteins with apparent molecular masses of 27, 28 and 30 kDa have been detected in isolated nuclei of etiolated pea plumules. After LDS‐PAGE and transfer to nitrocellulose these proteins bind [32p]GTP in the presence of excess ATP, suggesting that they are monomeric G proteins.
G B, Clark +4 more
openaire +2 more sources
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source