Results 171 to 180 of about 149,249 (343)

The GTPase κB-Ras is an essential subunit of the RalGAP tumor suppressor complex. [PDF]

J Biol Chem
Rasche R, Apken LH, Titze S, Michalke E, Singh RK, Oeckinghaus A, Kümmel D.   +6 more
europepmc   +1 more source

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

A tubulin-binding protein that preferentially binds to GDP-tubulin and promotes GTP exchange. [PDF]

J Biol Chem
Yon WJ, Ha T, Zheng Y, Pedersen RTA.
europepmc   +1 more source

Coexistence of APC and KRAS Mutations in Familial Adenomatous Polyposis and Endometrial Cancer: A Mini‐Review With Case‐Based Perspective

Med Research, EarlyView.
ABSTRACT Familial adenomatous polyposis (FAP) is a well‐characterized hereditary colorectal cancer syndrome driven by germline mutations in the APC gene. KRAS mutations, although more common in sporadic colorectal and endometrial cancers, are rarely seen concurrently in patients with FAP.
Tongchuan Yin, Zhenhua Tan, Lanjin Bai, Haibo Lan, Tianliang Liu   +4 more
wiley   +1 more source

The Rab3 family proteins in age-related neurodegeneration: unraveling molecular pathways and potential therapeutic targets. [PDF]

NPJ Aging
He H, Ai R, Fang EF, Palikaras K.
europepmc   +1 more source

Ferroptosis in Pneumoconiosis: From Molecular and Cellular Mechanisms to Therapeutic Strategies

Med Research, EarlyView.
Targeting lung various cells to alleviate pneumoconiosis by suppressing ferroptosis. AAV9‐HGF, adeno‐associated virus‐hepatocyte growth factor; DFP, deferiprone; DHQ, dihydroquercetin; Fer‐1, ferrostatin‐1; IL‐1β, interleukin‐1β; NMN, nicotinamide mononucleotide; sh‐SLC39A14, shRNA targeting solute carrier family 39 member 14; si‐OC‐STAMP, siRNA ...
Mengli Yan, Jing Zhang, Gaili Ji, Xiaobin Fang, Chunheng Mo   +4 more
wiley   +1 more source

Mitochondrial transfer as a novel therapeutic approach in ischemic stroke treatment: Current challenges and future perspectives

Neuroprotection, EarlyView.
Cerebral ischemia is a serious neurological disease that mainly leads to pathological changes such as mitochondrial dysfunction, oxidative stress and iron death. Mitochondria play a key role in the regulation of cellular energy metabolism and oxidative stress, and their damage can lead to mitochondrial damage, reduced adenosine triphosphate production,
Shuchen Meng, Min Bai, Changsheng Ma, Bo Han, Mengyuan Duan, Liying Zhang, Jinfen Guo, Changku Shi, Ke Li, Maotao He   +9 more
wiley   +1 more source

A cDNA from Medicago sativa Encodes a Protein Homologous to Small GTP-Binding Proteins

Plant Physiology, 1995
C. Jonak, E. Heberle‐Bors, H. Hirt
semanticscholar   +1 more source

RESEARCH CHALLENGES IN STAGE III AND IV RAS-ASSOCIATED CANCERS: A Narrative Review of the Complexities and Functions of the Family of <i>RAS</i> Genes and Ras Proteins in Housekeeping and Tumorigenesis. [PDF]

Biology (Basel)
McDonald RA, Varela-Ramirez A, Ashley AK.   +2 more
europepmc   +1 more source

Genome resequencing and genome‐wide polymorphisms in Chinese population of Phyllotreta striolata (Coleoptera, Chrysomelidae)

New Plant Protection, EarlyView.
The striped flea beetle, Phyllotreta striolata, is a globally notorious pest of cruciferous vegetables. In this study, we successfully sequenced the whole genome of the Chinese population of P. striolata. Comparative analysis with the reference genome of the Canadian population enabled a high‐resolution examination of genetic variation, which is ...
Kui Wang, Beibei Cao, Changlong Shu, Jie Zhang   +3 more
wiley   +1 more source