Results 171 to 180 of about 80,664 (305)

RAS-membrane interaction and oligomerization: there is more than meets the eye. [PDF]

Biochem Soc Trans
Sianoya AC, Bhardwaj VK, Gorfe AA.
europepmc   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, EarlyView.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

The mechanism of thioamide formation by the YcfA-YcfC system in 6-thioguanine biosynthesis. [PDF]

Nat Commun
Zhang L, Dou C, Yan W, Chen P, Jia X, Zhang N, Zhou D, Long Z, Zhang L, Zhu X, Cheng W.   +10 more
europepmc   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

A tubulin-binding protein that preferentially binds to GDP-tubulin and promotes GTP exchange. [PDF]

J Biol Chem
Yon WJ, Ha T, Zheng Y, Pedersen RTA.
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Advances in biomarkers of resistance to KRAS mutation-targeted inhibitors. [PDF]

Discov Oncol
Wang L, Wei D, Li S, Jiang S.
europepmc   +1 more source

Guanylate-binding proteins: emerging critical functions in plant development, immunity and stress response. [PDF]

New Phytol
Summary Guanylate‐binding proteins (GBPs) are large GTPases that belong to the Dynamin Superfamily Protein family. In humans, GBPs are well‐characterized interferon‐induced GTPases, playing a central role in cell‐autonomous innate immunity against infections, inflammation and cancer. GBPs orthologs have been identified in plants only recently.
Fernandez-Lochu L, Lemaire-Chamley M, Chevalier C.   +2 more
europepmc   +2 more sources

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source