Results 11 to 20 of about 154,453 (348)

Small GTP-binding protein Ran is regulated by posttranslational lysine acetylation [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance The small GTPase Ran plays fundamental roles in cellular processes such as nucleo-cytoplasmic transport, mitotic spindle formation, and nuclear envelope assembly. Recently, Ran was found to be lysine acetylated, among others, in functionally important regions such as switch I and switch II.
Susanne de Boor, P. Knyphausen, Nora Kuhlmann, Sarah Wroblowski, Julian Brenig, Lukas Scislowski, Linda Baldus, H. Nolte, M. Krüger, M. Lammers   +9 more
semanticscholar   +3 more sources

Regulation of lymphocyte-mediated killing by GTP-binding proteins [PDF]

Journal of Leukocyte Biology, 2003
Abstract Exocytosis of granules containing apoptosis-inducing proteins is one mechanism of target cell killing by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Granules containing perforin and granzymes are redistributed to the area of cell contact initiated by specific interactions between surface ligands on a target ...
Dianne, Khurana, Paul J, Leibson
openaire   +2 more sources

Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics [PDF]

Scientific Reports, 2017
AbstractThe mitotic spindle, essential for segregating the sister chromatids into the two evolving daughter cells, is composed of highly dynamic cytoskeletal filaments, the microtubules. The dynamics of microtubules are regulated by numerous microtubule associated proteins.
Schellhaus, A.K., Moreno-Andrés, D., Chugh, M., Yokoyama, H., Moschopoulou, A., De, S., Bono, F., Hipp, K., Schäffer, E., Antonin, W.   +9 more
openaire   +7 more sources

Rho GTPases as Key Molecular Players within Intestinal Mucosa and GI Diseases

Cells, 2021
Rho proteins operate as key regulators of the cytoskeleton, cell morphology and trafficking. Acting as molecular switches, the function of Rho GTPases is determined by guanosine triphosphate (GTP)/guanosine diphosphate (GDP) exchange and their lipidation
Rashmita Pradhan, Phuong A. Ngo, Luz d. C. Martínez-Sánchez, Markus F. Neurath, Rocío López-Posadas   +4 more
doaj   +1 more source

Computational study of the motor neuron protein KIF5A to identify nsSNPs, bioactive compounds, and its key regulators

Frontiers in Genetics, 2023
Introduction: Kinesin family member 5A (KIF5A) is a motor neuron protein expressed in neurons and involved in anterograde transportation of organelles, proteins, and RNA. Variations in the KIF5A gene that interfere with axonal transport have emerged as a
Rupesh Kumar, Thirumurthy Madhavan, Kalaiarasan Ponnusamy, Honglae Sohn, Shazia Haider   +4 more
doaj   +1 more source

Expression Levels of Genes Encoding Proteins Involved in the Cell Wall–Plasma Membrane–Cytoskeleton Continuum Are Associated With the Maturation-Related Adventitious Rooting Competence of Pine Stem Cuttings

Frontiers in Plant Science, 2022
Stem cutting recalcitrance to adventitious root formation is a major limitation for the clonal propagation or micropropagation of elite genotypes of many forest tree species, especially at the adult stage of development.
Alberto Pizarro, Carmen Díaz-Sala
doaj   +1 more source

Molecular architecture of Gαo and the structural basis for RGS16-mediated deactivation [PDF]

, 2008
Heterotrimeric G proteins relay extracellular cues from heptahelical transmembrane receptors to downstream effector molecules. Composed of an α subunit with intrinsic GTPase activity and a βγ heterodimer, the trimeric complex dissociates upon receptor ...
Berman, C.-K. Chen, Chan, Chen, Chen, Chen, Coleman, De Vries, Grafstein-Dunn, He, Heximer, K. C. Slep, Kimple, Koelle, Kozasa, Kozasa, Kudlacek, Lodowski, M. A. Kercher, M. I. Simon, McIntire, Neubig, Noel, P. B. Sigler, Slep, Snow, Sondek, Sunahara, T. Wieland, Tesmer, Tesmer, Valenzuela, Wang, Wilkie, Willars   +34 more
core   +4 more sources

GTP-Binding Proteins and Regulated Exocytosis [PDF]

Critical Reviews in Oral Biology & Medicine, 1999
Regulated exocytosis, which occurs in response to stimuli, is a two-step process involving the docking of secretory granules (SGs) at specific sites on the plasma membrane (PM), with subsequent fusion and release of granule contents. This process plays a crucial role in a number of tissues, including exocrine glands, chromaffin cells, platelets, and ...
openaire   +2 more sources

Dual positive and negative regulation of GPCR signaling by GTP hydrolysis [PDF]

, 2009
G protein-coupled receptors (GPCRs) regulate a variety of intracellular pathways through their ability to promote the binding of GTP to heterotrimeric G proteins. Regulator of G protein signaling (RGS) proteins increase the intrinsic GTPase activity of G-
Berg, Hugo van den, Davey, John, Godfrey, Emma L., Hill, Claire, Hodgkin, Matthew N., Ladds, Graham, Rand, D. A., Smith, Benjamin, Thornton, Steven   +8 more
core   +1 more source

The non-catalytic carboxyl-terminal domain of ARFGAP1 regulates actin cytoskeleton reorganization by antagonizing the activation of Rac1. [PDF]

PLoS ONE, 2011
The regulation of the actin cytoskeleton and membrane trafficking is coordinated in mammalian cells. One of the regulators of membrane traffic, the small GTP-binding protein ARF1, also activates phosphatidylinositol kinases that in turn affect actin ...
Ka Yu Siu, Mei Kuen Yu, Xinggang Wu, Min Zong, Michael G Roth, Hsiao Chang Chan, Sidney Yu   +6 more
doaj   +1 more source