Results 11 to 20 of about 104,022 (310)
Oncogene ect2 is related to regulators of small GTP-binding proteins [PDF]
Nature, 1993 We have developed an efficient expression cloning system that allows rapid isolation of complementary DNAs able to induce the transformed phenotype. We searched for molecules expressed in epithelial cells and possessing transforming potential to fibroblasts, and cloned a cDNA for the normal receptor of a growth factor secreted by NIH/3T3 cells. Here we
Toru Miki +4 more
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Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family. [PDF]
Proceedings of the National Academy of Sciences, 1995 Philadelphia chromosome-positive leukemias result from the fusion of the BCR and ABL genes, which generates a functional chimeric molecule. The Abr protein is very similar to Bcr but lacks a structural domain which may influence its biological regulatory capabilities. Both Abr and Bcr have a GTPase-activating protein (GAP) domain similar to those found
Tsung‐Hsien Chuang +5 more
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The small GTP-binding protein Rac is a regulator of cell death in plants [PDF]
Proceedings of the National Academy of Sciences, 1999 Cell death plays important roles in the development and defense of plants as in other multicellular organisms. Rapid production of reactive oxygen species often is associated with plant defense against pathogens, but their molecular mechanisms are not known.
Tsutomu Kawasaki +6 more
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An essential GTP‐binding protein functions as a regulator for differentiation in Streptomyces coelicolor [PDF]
Molecular Microbiology, 1998 The Streptomyces coelicolor obg gene, which encodes a putative GTP‐binding protein of the Obg/Gtp1 family, was characterized. The obg gene was essential for viability. Introduction of multiple copies of obg into wild‐type S. coelicolor suppressed aerial mycelium formation. A single amino acid substitution at any of six positions was introduced into the
Susumu Okamoto, Kozo Ochi
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Regulation of lymphocyte-mediated killing by GTP-binding proteins [PDF]
Journal of Leukocyte Biology, 2003 Abstract Exocytosis of granules containing apoptosis-inducing proteins is one mechanism of target cell killing by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Granules containing perforin and granzymes are redistributed to the area of cell contact initiated by specific interactions between surface ligands on a target ...
Dianne Khurana, Paul J. Leibson
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Frontiers in Plant Science, 2022 Stem cutting recalcitrance to adventitious root formation is a major limitation for the clonal propagation or micropropagation of elite genotypes of many forest tree species, especially at the adult stage of development.
Alberto Pizarro, Carmen Díaz-Sala
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Dependence of protein-induced lipid bilayer deformations on protein shape [PDF]
, 2022 Membrane proteins typically deform the surrounding lipid bilayer membrane, which can play an important role in the function, regulation, and organization of membrane proteins. Membrane elasticity theory provides a beautiful description of protein-induced lipid bilayer deformations, in which all physical parameters can be directly determined from ...
arxiv +1 more source
The non-catalytic carboxyl-terminal domain of ARFGAP1 regulates actin cytoskeleton reorganization by antagonizing the activation of Rac1. [PDF]
PLoS ONE, 2011 The regulation of the actin cytoskeleton and membrane trafficking is coordinated in mammalian cells. One of the regulators of membrane traffic, the small GTP-binding protein ARF1, also activates phosphatidylinositol kinases that in turn affect actin ...
Ka Yu Siu +6 more
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Frontiers in Genetics, 2022 Small GTPases are the key to actin cytoskeleton signaling, which opens the lock of effector proteins to forward the signal downstream in several cellular pathways. Actin cytoskeleton assembly is associated with cell polarity, adhesion, movement and other
Preeti Umarao +2 more
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Dual positive and negative regulation of GPCR signaling by GTP hydrolysis [PDF]
, 2009 G protein-coupled receptors (GPCRs) regulate a variety of intracellular pathways through their ability to promote the binding of GTP to heterotrimeric G proteins. Regulator of G protein signaling (RGS) proteins increase the intrinsic GTPase activity of G-
Berg, Hugo van den +8 more
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