Results 11 to 20 of about 149,249 (343)

Regulation of lymphocyte-mediated killing by GTP-binding proteins [PDF]

Journal of Leukocyte Biology, 2003
Abstract Exocytosis of granules containing apoptosis-inducing proteins is one mechanism of target cell killing by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Granules containing perforin and granzymes are redistributed to the area of cell contact initiated by specific interactions between surface ligands on a target ...
Dianne Khurana, Paul J. Leibson
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Regulation of the Single Polar Flagellar Biogenesis

Biomolecules, 2020
Some bacterial species, such as the marine bacterium Vibrio alginolyticus, have a single polar flagellum that allows it to swim in liquid environments.
Seiji Kojima, Hiroyuki Terashima, Michio Homma   +2 more
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ARHGEF3 regulates the stability of ACLY to promote the proliferation of lung cancer

Cell Death and Disease, 2022
Rho GTPases play an essential role in many cellular processes, including cell cycle progress, cell motility, invasion, migration, and transformation.
Feifei Zhou, Wenqian Ai, Yixing Zhang, Qifan Hu, Mingxi Gan, Jian-Bin Wang, Tianyu Han   +6 more
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Posttranslational modification of the RHO of plants protein RACB by phosphorylation and cross-kingdom conserved ubiquitination.

PLoS ONE, 2022
Small RHO-type G-proteins act as signaling hubs and master regulators of polarity in eukaryotic cells. Their activity is tightly controlled, as defective RHO signaling leads to aberrant growth and developmental defects.
Lukas Weiß, Lana Gaelings, Tina Reiner, Julia Mergner, Bernhard Kuster, Attila Fehér, Götz Hensel, Manfred Gahrtz, Jochen Kumlehn, Stefan Engelhardt, Ralph Hückelhoven   +10 more
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Oxytocin Downregulates the Ca_V1.2 L-Type Ca²⁺ Channel via Gi/cAMP/PKA/CREB Signaling Pathway in Cardiomyocytes

Membranes, 2021
Oxytocin (OT) and its receptor (OTR) are expressed in the heart and are involved in the physiological cardiovascular functional system. Although it is known that OT/OTR signaling is cardioprotective by reducing the inflammatory response and improving ...
Masaki Morishima, Shintaro Tahara, Yan Wang, Katsushige Ono   +3 more
doaj   +1 more source

Rho GTPases as Key Molecular Players within Intestinal Mucosa and GI Diseases

Cells, 2021
Rho proteins operate as key regulators of the cytoskeleton, cell morphology and trafficking. Acting as molecular switches, the function of Rho GTPases is determined by guanosine triphosphate (GTP)/guanosine diphosphate (GDP) exchange and their lipidation
Rashmita Pradhan, Phuong A. Ngo, Luz d. C. Martínez-Sánchez, Markus F. Neurath, Rocío López-Posadas   +4 more
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Computational study of the motor neuron protein KIF5A to identify nsSNPs, bioactive compounds, and its key regulators

Frontiers in Genetics, 2023
Introduction: Kinesin family member 5A (KIF5A) is a motor neuron protein expressed in neurons and involved in anterograde transportation of organelles, proteins, and RNA. Variations in the KIF5A gene that interfere with axonal transport have emerged as a
Rupesh Kumar, Thirumurthy Madhavan, Kalaiarasan Ponnusamy, Honglae Sohn, Shazia Haider   +4 more
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Expression Levels of Genes Encoding Proteins Involved in the Cell Wall–Plasma Membrane–Cytoskeleton Continuum Are Associated With the Maturation-Related Adventitious Rooting Competence of Pine Stem Cuttings

Frontiers in Plant Science, 2022
Stem cutting recalcitrance to adventitious root formation is a major limitation for the clonal propagation or micropropagation of elite genotypes of many forest tree species, especially at the adult stage of development.
Alberto Pizarro, Carmen Díaz-Sala
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Molecular architecture of Gαo and the structural basis for RGS16-mediated deactivation [PDF]

, 2008
Heterotrimeric G proteins relay extracellular cues from heptahelical transmembrane receptors to downstream effector molecules. Composed of an α subunit with intrinsic GTPase activity and a βγ heterodimer, the trimeric complex dissociates upon receptor ...
Berman, C.-K. Chen, Chan, Chen, Chen, Chen, Coleman, De Vries, Grafstein-Dunn, He, Heximer, K. C. Slep, Kimple, Koelle, Kozasa, Kozasa, Kudlacek, Lodowski, M. A. Kercher, M. I. Simon, McIntire, Neubig, Noel, P. B. Sigler, Slep, Snow, Sondek, Sunahara, T. Wieland, Tesmer, Tesmer, Valenzuela, Wang, Wilkie, Willars   +34 more
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GTP-Binding Proteins and Regulated Exocytosis [PDF]

Critical Reviews in Oral Biology & Medicine, 1999
Regulated exocytosis, which occurs in response to stimuli, is a two-step process involving the docking of secretory granules (SGs) at specific sites on the plasma membrane (PM), with subsequent fusion and release of granule contents. This process plays a crucial role in a number of tissues, including exocrine glands, chromaffin cells, platelets, and ...
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