Results 191 to 200 of about 80,664 (305)

Structural and functional dissection of the WH2/DAD motif of INF2, a formin linked to human inherited degenerative disorders

The FEBS Journal, EarlyView.
The INF2 WH2/DAD domain, composed of hydrophobic and basic regions, forms a single α‐helix in solution. The hydrophobic segment is essential for INF2 function, as its deletion disrupts actin dynamics and causes nuclear abnormalities, like those seen in pathogenic INF2 DID variants. In contrast, natural INF2 WH2/DAD variants found in patients with renal
Leticia Labat‐de‐Hoz, Laura Fernández‐Martín, Paula Morales, Isabel Correas, María Ángeles Jiménez, Miguel Angel Alonso   +5 more
wiley   +1 more source

The human autophagy-initiating complexes ULK1C and PI3KC3-C1. [PDF]

J Biol Chem
Chen M, Hurley JH.
europepmc   +1 more source

The importin‐alpha superfamily engages in ethylene signaling by shuttling ETHYLENE INSENSITIVE 2 from the endoplasmic reticulum to the nucleus

The FEBS Journal, EarlyView.
The plant hormone ethylene regulates plant growth, ripening, senescence, and stress responses. The hormonal signal transmission, from receptors at the ER membrane to the transcriptional regulators in the nucleus, is still not completely understood.
Fabian Wynen, Jan Eric Maika, Raphael Josef Eberle, Nina Jahnke, Marcel Wiermer, Laura Hartmann, Rüdiger Simon, Georg Groth   +7 more
wiley   +1 more source

Rap1 activity and localization is regulated by Rab40/CRL5 facilitated mono-ubiquitylation. [PDF]

MicroPubl Biol
Neumann A, Sampath R, Han KJ, Prekeris R.   +3 more
europepmc   +1 more source

Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics

The FEBS Journal, EarlyView.
We describe the CD9 interactome in epithelial cells for the first time. The interactome is diverse and dynamic and changes dependent on infection with specific bacteria. We validate these data by showing functional interaction between CD9 with CD44 or CD147. We therefore demonstrate that CD9 is a universal organiser of bacterial adhesion platforms able
Paige A. Wolverson, Isabel Fernandes Parreira, Ruth H. Thompson, Mark O. Collins, Jonathan G. Shaw, Luke R. Green   +5 more
wiley   +1 more source

Structure and mechanism of the RalGAP tumor suppressor complex. [PDF]

Nat Commun
Rasche R, Klink BU, Apken LH, Michalke E, Chen M, Oeckinghaus A, Gatsogiannis C, Kümmel D.   +7 more
europepmc   +1 more source

Polar‐localized EXO70G1 regulates root development in Arabidopsis thaliana

Journal of Integrative Plant Biology, EarlyView.
The putative exocyst subunit EXO70G1 exhibits apical‐basal polarity in Arabidopsis root cells; this polarity stabilizes membrane domains to facilitate targeting of the auxin transporter PIN‐FORMED2 during root development. ABSTRACT Cellular asymmetry, which represents a fundamental characteristic of cell polarity, is prominently illustrated by the ...
Juan Li, Zhendong Liu, Lixue Gong, Shuju Zhao, Qing Lu, Shan Gao, Su Jiang, Xiaonan Liu, Long Ma, Guangyou Duan, Dayong Cui, Shipeng Li   +11 more
wiley   +1 more source

Dominant Gα mutations in human disease: unifying mechanisms and treatment strategies. [PDF]

EMBO Mol Med
Katanaev VL, Solis GP.
europepmc   +1 more source

Essential developmental processes in Physcomitrium patens require distinct levels of total activity provided by functionally redundant PpROP GTPases

New Phytologist, EarlyView.
Summary RHO (RAS homologous) GTPases regulate important cellular and developmental processes in most eukaryotes. Plant‐specific ROP (RHO of plants) GTPase families expanded and functionally diversified during the evolution of vascular plants, but contain few members in nonvascular extant relatives of early land plants.
Aude Le Bail, Benedikt Kost, Janina Nüssel, Tamara Isabeau Lolis, David Koch, Hildegard Voll, Sylwia Schulmeister, Alexander Kaier, Karin Ljung, Maria Ntefidou   +9 more
wiley   +1 more source

Regulation of actin cytoskeletal dynamics in T cell development and function. [PDF]

Front Immunol
Lam TT, Chong MMW.
europepmc   +1 more source