Results 191 to 200 of about 149,249 (343)

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

Differential Protein Dynamics of Regulators of G-Protein Signaling: Role in Specificity of Small-Molecule Inhibitors.

Journal of the American Chemical Society, 2018
Vincent S. Shaw, Hossein Mohammadiarani, Harish Vashisth, R. Neubig   +3 more
semanticscholar   +1 more source

Regulation of actin cytoskeletal dynamics in T cell development and function. [PDF]

Front Immunol
Lam TT, Chong MMW.
europepmc   +1 more source

Mitochondrial dynamics in autoimmune diseases

Rheumatology &Autoimmunity, EarlyView.
Roles of mitochondrial dynamic imbalance in autoimmune diseases. The imbalance of mitochondrial fusion and fission is involved in the occurrence and development of autoimmune diseases, including systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, type 1 diabetes, psoriasis, and autoimmune ...
Ruicong Ma, Cheng Zhang, Jiaqing Liu, Jinyi Ren, Xia Li, Ying Zhao   +5 more
wiley   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

The protein kinases family in fungi: adaptability, virulence and conservation between species. [PDF]

Front Microbiol
La Santrer E, Assunção CB, de Camargo TMN, Rodrigues I, Campolina SS, de Aguiar EL, de Souza Rodrigues T, Caligiorne RB.   +7 more
europepmc   +1 more source

The Extremely Low Mechanical Force Generated by Nano‐Pulling Induces Global Changes in the Microtubule Network, Nuclear Morphology, and Chromatin Transcription in Neurons

Small, EarlyView.
Nano‐pulling induces stabilization, reorganization, and reorientation of the microtubule network. The nucleus of stretched cells experiences increased lateral tension, becomes more spherical, and develops surface grooves. At the level of gene expression regulation, changes in nuclear morphology induce global chromatin remodeling, leading to reduced ...
Alessandro Falconieri, Lorenzo Da Palmata, Valentina Cappello, Tiziana Julia Nadjeschda Schmidt, Pietro Folino, Barbara Storti, Ranieri Bizzarri, Vittoria Raffa   +7 more
wiley   +1 more source

The ubiquitin code of RAS proteins: Decoding its role in cancer progression. [PDF]

iScience
Shi Y, Shen Y, Zhang X, Zhu N, Ding Y, Yuan Y, Wang J.   +6 more
europepmc   +1 more source

Differential gene expression in Chorthippus parallelus (Zetterstedt, 1821) (Orthoptera: Acrididae: Gomphocerinae) induced by Wolbachia infection

Insect Science, EarlyView.
Distinct lineages of the grasshopper Chorthippus parallelus (Orthoptera: Acrididae) form a well‐known hybrid zone (HZ) in the Pyrenees mountain range; the Iberian endemism C. p. erythropus (Cpe) and the subspecies C. p. parallelus, (Cpp) widely distributed throughout the rest of Europe. Both subspecies differ in diverse traits, including the strains of
Patricia Jiménez‐Florido, Mónica Aquilino, David Buckley, José L. Bella, Rosario Planelló   +4 more
wiley   +1 more source

Beyond division and morphogenesis: Considering the emerging roles of septins in plasma membrane homeostasis and cell wall integrity in human fungal pathogens. [PDF]

PLoS Pathog
Martinez Barrera S, Kozubowski L.
europepmc   +1 more source