Results 241 to 250 of about 149,249 (343)

Elongation factor 2 in cancer: a promising therapeutic target in protein translation. [PDF]

Cell Mol Biol Lett
Jia X, Huang C, Liu F, Dong Z, Liu K.
europepmc   +1 more source

The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function

The Journal of Physiology, EarlyView.
Abstract figure legend The synaptic vesicle cluster acts as a master regulator of synaptic structure and function, through various involvements in processes that range from synaptic initiation to plasticity and synaptic loss. Abstract The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter ...
Sofiia Reshetniak, Cristian A. Bogaciu, Stefan Bonn, Nils Brose, Benjamin H. Cooper, Elisa D'Este, Michael Fauth, Rubén Fernández‐Busnadiego, Maksims Fiosins, André Fischer, Svilen V. Georgiev, Stefan Jakobs, Stefan Klumpp, Sarah Köster, Felix Lange, Noa Lipstein, Victor Macarrón‐Palacios, Dragomir Milovanovic, Tobias Moser, Marcus Müller, Felipe Opazo, Tiago F. Outeiro, Constantin Pape, Viola Priesemann, Peter Rehling, Tim Salditt, Oliver Schlüter, Nadja Simeth, Claudia Steinem, Tatjana Tchumatchenko, Christian Tetzlaff, Marilyn Tirard, Henning Urlaub, Carolin Wichmann, Fred Wolf, Silvio O. Rizzoli   +35 more
wiley   +1 more source

Membrane trafficking of synaptic adhesion molecules

The Journal of Physiology, EarlyView.
Abstract figure legend Synaptic cellular adhesion molecules are surface transmembrane receptors that have been shown to internalize via endocytosis, and possibly also recycle, in a process that has been linked to the function and the turnover of the synaptic contact site.
Cristian A. Bogaciu, Silvio O. Rizzoli
wiley   +1 more source

Intersectin‐1 enhances calcium‐dependent replenishment of the readily releasable pool of synaptic vesicles during development

The Journal of Physiology, EarlyView.
Abstract figure legend During development, Intersectin‐1 (Itsn1) translocates near voltage‐gated calcium channels (VGCCs) to enhance Ca2+‐dependent replenishment of readily releasable synaptic vesicles (SVs). In the presynaptic terminal, SVs undergo a cycle involving formation (step 1), docking (step 2), exocytosis (step 3), endocytosis (step 4) and ...
Yi‐Mei Yang, Adam Fekete, Jason Arsenault, Ameet S. Sengar, Jamila Aitoubah, Giovanbattista Grande, Angela Li, Eric W. Salter, Alex Wang, Melanie D. Mark, Stefan Herlitze, Sean E. Egan, Michael W. Salter, Lu‐Yang Wang   +13 more
wiley   +1 more source

Persistence of quantal synaptic vesicle recycling in virtual absence of dynamins

The Journal of Physiology, EarlyView.
Abstract figure legend Figure depicts the key finding from this study. While loss of all dynamins severely debilitates synaptic vesicle retrieval following repetitive activity, retrieval and recycling of individual synaptic vesicles following spontaneous fusion or sparse stimulation are minimally affected.
Olusoji A. T. Afuwape, Natali L. Chanaday, Merve Kasap, Lisa M. Monteggia, Ege T. Kavalali   +4 more
wiley   +1 more source

Structural insights, regulation, and recent advances of RAS inhibitors in the MAPK signaling cascade: a medicinal chemistry perspective. [PDF]

RSC Med Chem
Prajapati V, Singh AK, Kumar A, Singh H, Pathak P, Grishina M, Kumar V, Khalilullah H, Verma A, Kumar P.   +9 more
europepmc   +1 more source

Blebbistatin reduces calcium buffering in cardiomyocytes: Consequences for cellular electrophysiology

The Journal of Physiology, EarlyView.
Abstract figure legend Blebbistatin reduces Ca2+ buffering in induced pluripotent stem cell‐derived atrial cardiomyocytes. Blebbistatin, a widely used excitation–contraction uncoupling agent, decreases calcium (Ca2+) buffer affinity (increased buffer dissociation constant), leading to elevated diastolic Ca2+ levels, increased sarcoplasmic reticulum Ca2+
Izzatullo Sobitov, Katharina Ritzenhoff, Marie Gaulrapp, Lea Becker, Aiste Liutkute, Fitzwilliam Seibertz, Funsho E. Fakuade, Fleur E. Mason, Niels Voigt   +8 more
wiley   +1 more source

ARF6 as a Novel Activator of HIF-2α in Pulmonary Arterial Hypertension. [PDF]

Am J Respir Cell Mol Biol
Fellows AL, Chen CN, Xie C, Iyer N, Schmidt L, Yin X, Yates LA, Mayr M, Cowburn A, Zhao L, Wojciak-Stothard B.   +10 more
europepmc   +1 more source

Contusive spinal cord injury causes Nav1.8 dysfunction to upregulate small sensory neuron excitability

The Journal of Physiology, EarlyView.
Abstract figure legend Contusive SCI significantly dysregulated excitability of small DRG neurons by enhancing Nav1.8 function. SCI‐induced hyperexcitability was partially reversed by ZL0177, a small compound disrupting FHF interaction with Nav1.8 and Nav1.9.
Yucheng Xiao, Yanling Pan, Naikui Liu, Theodore R. Cummins   +3 more
wiley   +1 more source

Eukaryotic initiation factors: central factor associating mRNA translational plasticity during neuropathic pain progression. [PDF]

Front Neurol
Li X, Zhan H, Zhang X, Li J, Li X, Lu X, Miao C, Zhou C, Zhang Z.   +8 more
europepmc   +1 more source