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Small GTP-binding proteins and their regulators in cardiac hypertrophy
Small GTP-binding proteins (small G proteins) act as GDP-GTP-regulated molecular switches and are activated by guanine nucleotide exchange factors (GEFs) in response to diverse extracellular stimuli. During this last decade, numerous molecular and cellular studies, as well as genetically-modified animal models, have highlighted the role of small G ...
Frank Lezoualc’h +4 more
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Small GTP-binding Proteins—A New Family of Biologic Regulators
Alan Hall
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Highlight: GTP Binding Proteins Central Regulators in Cell Biology
A. Wittinghofer, Peter Gierschik
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Regulation of small GTP-binding proteins by insulin [PDF]
Several members of the extensive family of small GTP-binding proteins are regulated by insulin, and have been implicated in insulin action on glucose uptake. These proteins are themselves negatively regulated by a series of specific GAPs (GTPase-activating proteins).
Ingeborg Hers +3 more
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Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation
Biochemical and Biophysical Research Communications, 2021Developmentally regulated GTP-binding protein 2 (DRG2) participates in the regulation of proliferation and differentiation of multiple cells. However, whether DRG2 regulates adipocyte differentiation and related metabolic control remains elusive. This study revealed increases in body weight and adiposity in DRG2 transgenic (Tg) mice overexpressing DRG2.
Nal Ae Yoon +7 more
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Regulators of Signal Transduction: Families of GTP-Binding Proteins
Richard Kahn
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Common Properties of Receptors Coupled to GTP Binding Regulator Proteins
A number of membrane receptors coupled to GTP binding regulatory proteins have recently been shown to share structural propertie at the level both of the genes and of the corresponding proteins (Fig. 1 and 2). By comparing results obtained for α2-, β1- and β2-adrenergic catecholamine receptors, M1 to M5 muscarinic acetylcholine receptors as well as ...
Laurent J. Emorine +6 more
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Regulation of Rod GTP Binding Protein by Guanine Nucleotides1
The Journal of Biochemistry, 1984The rod GTP-binding protein in the bovine disk membrane seems to exist as oligomers in the dark. G alpha and G beta do not interact strongly, and G gamma may be required for G alpha . GDP to dimerize.
Hitoshi Shichi, Robert L. Somers
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Tumour suppressors and the regulation of GTP-binding protein activity
Trends in Cell Biology, 1993GTP-binding proteins regulate a wide variety of intracellular signalling pathways in eukaryotic cells. The Ras GTP-binding proteins have received a great deal of attention since they were found to be modified by amino acid substitutions in a large number of cancers.
Isabelle Rey, Alan Hall
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