Results 241 to 250 of about 104,548 (291)

New Transferrin Receptor‐Targeting Conjugate Effectively Delivers DNA to Mouse Brain

Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.
We present a novel RNA aptamer targeting the transferrin receptor (TfR), conjugated with DSPE lipid, which achieves remarkably efficient brain uptake, reaching brain‐to‐serum ratios as high as 6.5. Through fluorescence imaging and polymerase‐chain reaction analyses, we verify that this new conjugate successfully delivers a substantial amount of DNA ...
Min‐sun Song, Adrian H. Bustos, Lise Bastue, Justas Mikutavicius, Piotr Swiderski, Kelly J. Clemens, Nagy Habib, John Rossi, Kira Astakhova   +8 more
wiley   +2 more sources

Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
Cyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Vik S. Bebarta, Anjali K. Nath
wiley   +1 more source

Impacts of Circular RNAs on the Osteogenic Differentiation of Dental Stem Cells. [PDF]

Stem Cells Int
Wang Y, Tu M, Gao H, Deng S.
europepmc   +1 more source

Aspartate Is A Determinant of TNF‐α Biogenesis in Sub‐Saharan Africa: Insight Into the Pathogenesis of Noncommunicable Diseases

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
Proposed change in TNF‐α biogenesis with urbanization in sub‐Saharan Africa. Higher levels of aspartate in the rural population result in a NAD+ rich environment that favors stabilization of the endoplasmic reticulum (ER) membrane and suppressing TNF‐α.
Stephen W. Bickler, David M. Cauvi, Jack A. Gilbert, Romeo C. Ignacio, Emmanuel A. Ameh, Robert T. Schooley, Emilia V. Noormahomed   +6 more
wiley   +1 more source

Cell polarity control by an unconventional G-protein complex in bacteria

Dinet C, Sebban-Kreuzer C, Byrne-Kodjabachian D, Lhospice S, Herrou J, Durbesson F, Vincentelli R, Michelot A, Mignot T.   +8 more
europepmc   +1 more source

The Nucleoporin CPR5 Modulates Plant Immunity via Guanylate-Binding Proteins. [PDF]

Mol Plant Pathol
Pan L, Peng S, Zhang Y, Xu F, Cai X, Liang S, Huang Q, Yu S, Wang S.   +8 more
europepmc   +1 more source

Phase Separation and a Hydrodynamic Instability Localize Proteins at Growing Microtubule Ends

Schaer J, Miesch J, Catapano V, Dumoulin L, Tran J, Velluz M, Aumeier C, Kruse K.   +7 more
europepmc   +1 more source

Ciliary G-Protein Coupled Receptor Signaling in Polycystic Kidney Disease. [PDF]

Int J Mol Sci
Buqaileh R, Alshriem LA, AbouAlaiwi W.
europepmc   +1 more source

Ragopathies and the rising influence of RagGTPases on human diseases. [PDF]

Nat Commun
Sambri I, Ferniani M, Ballabio A.
europepmc   +1 more source