Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]
, 2004 Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Morales-Johansson, Helena
core +2 more sources
High throughput transcriptome profiling of lithium stimulated human mesenchymal stem cells reveals priming towards osteoblastic lineage. [PDF]
PLoS ONE, 2013 Human mesenchymal stem cells (hMSCs) present in the bone marrow are the precursors of osteoblasts, chondrocytes and adipocytes, and hold tremendous potential for osteoregenerative therapy.
Neeraj Kumar Satija +4 more
doaj +1 more source
Nitric Oxide Mediates Biofilm Formation and Symbiosis in Silicibacter sp. Strain TrichCH4B. [PDF]
, 2015 UnlabelledNitric oxide (NO) plays an important signaling role in all domains of life. Many bacteria contain a heme-nitric oxide/oxygen binding (H-NOX) protein that selectively binds NO.
Marletta, Michael A +2 more
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Function and regulation of Rnd proteins in cortical projection neuron migration
Frontiers in Neuroscience, 2015 The mammalian cerebral cortex contains a high variety of neuronal subtypes that acquire precise spatial locations and form long or short-range connections to establish functional neuronal circuits.
Roberta eAzzarelli +3 more
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BMC Genomics, 2005 BackgroundSmall G proteins, which are essential regulators of multiple cellular functions, are activated by guanine nucleotide exchange factors (GEFs) that stimulate the exchange of the tightly bound GDP nucleotide by GTP.
B. Mouratou +8 more
semanticscholar +1 more source
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton [PDF]
The EMBO Journal, 1999 Soluble factors from serum such as lysophosphatidic acid (LPA) are thought to activate the small GTP-binding protein Rho based on their ability to induce actin stress fibers and focal adhesions in a Rho-dependent manner. Cell adhesion to extracellular matrices (ECM) has also been proposed to activate Rho, but this point has been controversial due to ...
X D, Ren, W B, Kiosses, M A, Schwartz
openaire +2 more sources
Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac. [PDF]
PLoS ONE, 2010 The intracellular bacterium Chlamydia trachomatis causes infections of urogenital tract, eyes or lungs. Alignment reveals homology of CT166, a putative effector protein of urogenital C. trachomatis serovars, with the N-terminal glucosyltransferase domain
Jessica Thalmann +7 more
doaj +1 more source
Identifying conformational changes with site-directed spin labeling reveals that the GTPase domain of HydF is a molecular switch [PDF]
, 2017 [FeFe]-hydrogenases catalyse the reduction of protons to hydrogen at a complex 2Fe[4Fe4S] center called H-cluster. The assembly of this active site is a multistep process involving three proteins, HydE, HydF and HydG.
Acquasaliente, Laura +8 more
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Journal of Biological Chemistry, 2000 To investigate the potential role of trimeric GTP-binding proteins regulating GLUT4 translocation in adipocytes, wild type and constitutively active Gq(Gq/Q209L), Gi (Gi/Q205L), and Gs (Gs/Q227L) α subunit mutants were expressed in 3T3L1 adipocytes ...
M. Kanzaki +3 more
semanticscholar +1 more source
Atypical Rho GTPases of the RhoBTB Subfamily: Roles in vesicle trafficking and tumorigenesis [PDF]
, 2016 RhoBTB proteins constitute a subfamily of atypical Rho GTPases represented in mammals by RhoBTB1, RhoBTB2, and RhoBTB3. Their characteristic feature is a carboxyl terminal extension that harbors two BTB domains capable of assembling cullin 3-dependent ...
Ji, Wei, Rivero, Francisco
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