Results 41 to 50 of about 153,070 (268)

RBEL1 Is a Novel Gene That Encodes a Nucleocytoplasmic Ras Superfamily GTP-binding Protein and Is Overexpressed in Breast Cancer*

Journal of Biological Chemistry, 2007
Rab family proteins are generally known as regulators of protein transport and trafficking. A number of Rab proteins have been implicated in cancer development and/or progression.
J. Montalbano, W. Jin, M. Sheikh, Ying Huang   +3 more
semanticscholar   +1 more source

Structural Insights into HypB, a GTP-binding Protein That Regulates Metal Binding [PDF]

Journal of Biological Chemistry, 2006
HypB is a prokaryotic metal-binding guanine nucleotide-binding protein that is essential for nickel incorporation into hydrogenases. Here we solved the x-ray structure of HypB from Methanocaldococcus jannaschii. It shows that the G-domain has a different topology than the Ras-like proteins and belongs to the SIMIBI (after Signal Recognition Particle ...
Raphael, Gasper, Andrea, Scrima, Alfred, Wittinghofer   +2 more
openaire   +2 more sources

Differential proteome analysis of pea roots at the early stages of symbiosis with nodule bacteria

Вавиловский журнал генетики и селекции, 2018
In this paper, we have analyzed changes in the proteomic spectrum of pea Pisum sativum L. roots during inoculation with rhizobial bacteria with the aim of revealing new regulators of symbiosis development. To study the changes in the proteome spectrum of
I. V. Leppyanen, A. N. Kirienko, A. A. Lobov, E. A. Dolgikh   +3 more
doaj   +1 more source

The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p. [PDF]

, 2016
Sec2p is a guanine nucleotide exchange factor that activates Sec4p, the final Rab GTPase of the yeast secretory pathway. Sec2p is recruited to secretory vesicles by the upstream Rab Ypt32p acting in concert with phosphatidylinositol-4-phosphate (PI(4)P).
Novick, Peter J, Stalder, Danièle
core   +2 more sources

Phytochrome regulates GTP‐binding protein activity in the envelope of pea nuclei [PDF]

The Plant Journal, 1993
Three GTP‐binding proteins with apparent molecular masses of 27, 28 and 30 kDa have been detected in isolated nuclei of etiolated pea plumules. After LDS‐PAGE and transfer to nitrocellulose these proteins bind [32p]GTP in the presence of excess ATP, suggesting that they are monomeric G proteins.
G B, Clark, A R, Memon, , Tong C-G, G A, Thompson, S J, Roux   +4 more
openaire   +2 more sources

A role for Regulator of G protein Signaling-12 (RGS12) in the balance between myoblast proliferation and differentiation.

PLoS ONE, 2019
Regulators of G Protein Signaling (RGS proteins) inhibit G protein-coupled receptor (GPCR) signaling by accelerating the GTP hydrolysis rate of activated Gα subunits.
Adam B Schroer, Junaith S Mohamed, Melinda D Willard, Vincent Setola, Emily Oestreich, David P Siderovski   +5 more
doaj   +1 more source

Vascular Growth in the Fetal Lung [PDF]

, 2011
The structure of the lung is truly remarkable. It is primarily composed of three branched tubular networks (the airway, pulmonary artery and vein, bronchial artery and vein) which supply blood and air to the site of gas exchange and which maintain ...
Land, Stephen
core   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Pathogenic single nucleotide polymorphisms in RhoA gene: Insights into structural and functional impacts on RhoA-PLD1 interaction through molecular dynamics simulation

Current Research in Structural Biology
Molecular switches serve as key regulators of biological systems by acting as one of the crucial driving forces in the initiation of signal transduction pathway cascades.
Mahbub Hasan, Md. Nayem Sarker, Tazkia Jabin, Saifuddin Sarker, Shamim Ahmed, Mohammad Abdullah-Al-Shoeb, Tanvir Hossain   +6 more
doaj   +1 more source

Intrinsic tethering activity of endosomal Rab proteins. [PDF]

, 2011
Rab small G proteins control membrane trafficking events required for many processes including secretion, lipid metabolism, antigen presentation and growth factor signaling.
Brett, Christopher L, Fields, Stanley, Gonen, Tamir, Lo, Sheng-Ying, Merz, Alexey J, Plemel, Rachael L, Vignali, Marissa   +6 more
core   +3 more sources