Results 41 to 50 of about 149,249 (343)

Identifying conformational changes with site-directed spin labeling reveals that the GTPase domain of HydF is a molecular switch [PDF]

, 2017
[FeFe]-hydrogenases catalyse the reduction of protons to hydrogen at a complex 2Fe[4Fe4S] center called H-cluster. The assembly of this active site is a multistep process involving three proteins, HydE, HydF and HydG.
Acquasaliente, Laura, Bortolus, Marco, Carbonera, Donatella, Costantini, Paola, DE FILIPPIS, Vincenzo, DE ROSA, Edith, Doni, Davide, Galazzo, Laura, Maso, Lorenzo   +8 more
core   +1 more source

The Trimeric GTP-binding Protein (Gq/G11) α Subunit Is Required for Insulin-stimulated GLUT4 Translocation in 3T3L1 Adipocytes*

Journal of Biological Chemistry, 2000
To investigate the potential role of trimeric GTP-binding proteins regulating GLUT4 translocation in adipocytes, wild type and constitutively active Gq(Gq/Q209L), Gi (Gi/Q205L), and Gs (Gs/Q227L) α subunit mutants were expressed in 3T3L1 adipocytes ...
M. Kanzaki, R. Watson, N. Artemyev, J. Pessin   +3 more
semanticscholar   +1 more source

RBEL1 Is a Novel Gene That Encodes a Nucleocytoplasmic Ras Superfamily GTP-binding Protein and Is Overexpressed in Breast Cancer*

Journal of Biological Chemistry, 2007
Rab family proteins are generally known as regulators of protein transport and trafficking. A number of Rab proteins have been implicated in cancer development and/or progression.
J. Montalbano, W. Jin, M. Sheikh, Ying Huang   +3 more
semanticscholar   +1 more source

Differential proteome analysis of pea roots at the early stages of symbiosis with nodule bacteria

Вавиловский журнал генетики и селекции, 2018
In this paper, we have analyzed changes in the proteomic spectrum of pea Pisum sativum L. roots during inoculation with rhizobial bacteria with the aim of revealing new regulators of symbiosis development. To study the changes in the proteome spectrum of
I. V. Leppyanen, A. N. Kirienko, A. A. Lobov, E. A. Dolgikh   +3 more
doaj   +1 more source

A role for Regulator of G protein Signaling-12 (RGS12) in the balance between myoblast proliferation and differentiation.

PLoS ONE, 2019
Regulators of G Protein Signaling (RGS proteins) inhibit G protein-coupled receptor (GPCR) signaling by accelerating the GTP hydrolysis rate of activated Gα subunits.
Adam B Schroer, Junaith S Mohamed, Melinda D Willard, Vincent Setola, Emily Oestreich, David P Siderovski   +5 more
doaj   +1 more source

The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p. [PDF]

, 2016
Sec2p is a guanine nucleotide exchange factor that activates Sec4p, the final Rab GTPase of the yeast secretory pathway. Sec2p is recruited to secretory vesicles by the upstream Rab Ypt32p acting in concert with phosphatidylinositol-4-phosphate (PI(4)P).
Novick, Peter J, Stalder, Danièle
core   +2 more sources

Atypical Rho GTPases of the RhoBTB Subfamily: Roles in vesicle trafficking and tumorigenesis [PDF]

, 2016
RhoBTB proteins constitute a subfamily of atypical Rho GTPases represented in mammals by RhoBTB1, RhoBTB2, and RhoBTB3. Their characteristic feature is a carboxyl terminal extension that harbors two BTB domains capable of assembling cullin 3-dependent ...
Ji, Wei, Rivero, Francisco
core   +2 more sources

Insulin Action on Polyunsaturated Phosphatidic Acid Formation in Rat Brain: An “In Vitro” Model with Synaptic Endings from Cerebral Cortex and Hippocampus [PDF]

, 2009
The highly efficient formation of phosphatidic acid from exogenous 1-stearoyl-2-arachidonoyl-sn-glycerol (SAG) in rat brain synaptic nerve endings (synaptosomes) from cerebral cortex and hippocampus is reported.
Giusto, Norma Maria, Ilincheta, Monica Graciela, Zulian, Sandra Edith   +2 more
core   +1 more source

Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics [PDF]

Scientific Reports, 2017
AbstractThe mitotic spindle, essential for segregating the sister chromatids into the two evolving daughter cells, is composed of highly dynamic cytoskeletal filaments, the microtubules. The dynamics of microtubules are regulated by numerous microtubule associated proteins.
Wolfram Antonin, Wolfram Antonin, Fulvia Bono, Daniel Moreno-Andrés, Daniel Moreno-Andrés, Athina Moschopoulou, Mayank Chugh, Suman De, Anna Katharina Schellhaus, Anna Katharina Schellhaus, Erik Schäffer, Katharina Hipp, Hideki Yokoyama, Hideki Yokoyama   +13 more
openaire   +5 more sources

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source