Results 251 to 260 of about 232,963 (342)

Isoprenoid modification of G25K (Gp), a low molecular mass GTP-binding protein distinct from p21ras.

, 1990
William A. Maltese, Kathleen Sheridan
openalex   +1 more source

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, EarlyView.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

CLIC5A binds to and stabilizes the open and active conformation of ezrin. [PDF]

J Biol Chem
Rahman MM, Kim JS, Li L, Feisal MR, Mak KYL, Tavasoli M, Wang Z, Ballermann BJ, Hwang PM.   +8 more
europepmc   +1 more source

Removal of Rab GTP-binding proteins from Golgi membranes by GDP dissociation inhibitor inhibits inter-cisternal transport in the Golgi stacks.

, 1994
Zvulun Elazar, Thomas U. Mayer, James E. Rothman   +2 more
openalex   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

The GTPase κB-Ras is an essential subunit of the RalGAP tumor suppressor complex. [PDF]

J Biol Chem
Rasche R, Apken LH, Titze S, Michalke E, Singh RK, Oeckinghaus A, Kümmel D.   +6 more
europepmc   +1 more source

Stimulus-induced dissociation of alpha subunits of heterotrimeric GTP-binding proteins from the cytoskeleton of human neutrophils.

, 1993
Eva Särndahl, Gary Bokoch, Olle Stendahl, Tommy Andersson   +3 more
openalex   +1 more source

Structural and functional dissection of the WH2/DAD motif of INF2, a formin linked to human inherited degenerative disorders

The FEBS Journal, EarlyView.
The INF2 WH2/DAD domain, composed of hydrophobic and basic regions, forms a single α‐helix in solution. The hydrophobic segment is essential for INF2 function, as its deletion disrupts actin dynamics and causes nuclear abnormalities, like those seen in pathogenic INF2 DID variants. In contrast, natural INF2 WH2/DAD variants found in patients with renal
Leticia Labat‐de‐Hoz, Laura Fernández‐Martín, Paula Morales, Isabel Correas, María Ángeles Jiménez, Miguel Angel Alonso   +5 more
wiley   +1 more source

Loss-of-function coding variants in the Ras of complex proteins/GTPase domain of leucine rich repeat kinase 2. [PDF]

Protein Sci
Butterfield S, Herbst S, Lewis PA.
europepmc   +1 more source

Binding of Bacillus subtilis dynamin‐like protein DynA to the bacterial membrane is essential for effective phage defense

The FEBS Journal, EarlyView.
The bacterial dynamin‐like protein DynA from Bacillus subtilis plays a key role in phage defense. It binds the plasma membrane through a unique paddle domain in its D1 subunit. This membrane association is essential for its protective function, likely preventing explosive membrane rupture following phage infection.
Samia Shafqat, Urska Repnik, Marc Bramkamp   +2 more
wiley   +1 more source