PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity [PDF]
, 2016 The phosphodiesterase 6 delta subunit (PDE6δ) shuttles several farnesylated cargos between membranes. The cargo sorting mechanism between cilia and other compartments is not understood.
Fansa, Eyad Kalawy +4 more
core +1 more source
Thermodynamic bounds on the ultra- and infra-affinity of Hsp70 for its substrates [PDF]
, 2017 The 70 kDa Heat Shock Proteins Hsp70 have several essential functions in living systems, such as protecting cells against protein aggregation, assisting protein folding, remodeling protein complexes and driving the translocation into organelles.
Hartich, David +3 more
core +2 more sources
Concerted Complex Assembly and GTPase Activation in the Chloroplast Signal Recognition Particle [PDF]
, 2011 The universally conserved signal recognition particle (SRP) and SRP receptor (SR) mediate the cotranslational targeting of proteins to cellular membranes.
Chandrasekar, Sowmya +4 more
core +3 more sources
IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells
International Journal of Cell Biology, 2012 IQGAPs are a family of scaffolding proteins with multiple domains, named for the IQ motifs and GTPase activating protein (GAP) related domains. Despite their GAP homology, IQGAP proteins act as effectors for GTP-bound GTPases of the Ras superfamily and ...
Katie B. Shannon
doaj +1 more source
The GTP- and Phospholipid-Binding Protein TTD14 Regulates Trafficking of the TRPL Ion Channel in Drosophila Photoreceptor Cells. [PDF]
PLoS Genetics, 2015 Recycling of signaling proteins is a common phenomenon in diverse signaling pathways. In photoreceptors of Drosophila, light absorption by rhodopsin triggers a phospholipase Cβ-mediated opening of the ion channels transient receptor potential (TRP) and ...
Alexander C Cerny +7 more
doaj +1 more source
Mutations in human dynamin block an intermediate stage in coated vesicle formation [PDF]
, 1993 The role of human dynamin in receptor-mediated endocytosis was investigated by transient expression of GTP-binding domain mutants in mammalian cells. Using assays which detect intermediates in coated vesicle formation, the dynamin mutants were found to ...
Damke, Hanna +5 more
core +3 more sources
Molecules and mechanisms that regulate multipolar migration in the intermediate zone
Frontiers in Cellular Neuroscience, 2014 Most neurons migrate with an elongated, bipolar morphology, extending a long leading process that explores the environment. However, when immature projection neurons enter the intermediate zone of the neocortex they become multipolar.
Jonathan A Cooper
doaj +1 more source
Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification
Frontiers in Molecular Biosciences, 2021 RAS is a founding member of the RAS superfamily of GTPases. These small 21 kDa proteins function as molecular switches to initialize signaling cascades involved in various cellular processes, including gene expression, cell growth, and differentiation ...
Natsuki Osaka +18 more
doaj +1 more source
Analysis of Binding Site Hot Spots on the Surface of Ras GTPase [PDF]
, 2011 We have recently discovered an allosteric switch in Ras, bringing an additional level of complexity to this GTPase whose mutants are involved in nearly 30% of cancers.
Buhrman, Greg +9 more
core +2 more sources
Journal of Biological Chemistry, 1996 Certain small GTP-binding proteins control the enzymatic activity of a family of closely related serine-threonine kinases known as mitogen-activated protein kinases (MAPKs).
H. Teramoto +4 more
semanticscholar +1 more source