Results 1 to 10 of about 278,687 (359)
Detecting the Activation of Endogenous Small GTPases via Fluorescent Signals Utilizing a Split mNeonGreen: Small GTPase ActIvitY ANalyzing (SAIYAN) System [PDF]
Bio-ProtocolSmall GTPases function as molecular switches in cells, and their activation triggers diverse cellular responses depending on the GTPase type. Therefore, visualizing small GTPase activation in living cells is crucial because their activity is tightly ...
Miharu Maeda, Kota Saito
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Abstract P-26: Staphylococcus Aureus 30S Ribosomal Subunit in a Complex with the Era GTPase: Sample Preparation for Cryo-EM [PDF]
International Journal of Biomedicine, 2021 Background: An essential in bacteria GTPase Era is a multifunctional protein that is involved in cell cycle regulation and appears to play a significant role in ribosome biogenesis. It is required for the maturation of the 30S ribosomal subunit.
Evelina Klochkova +5 more
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WormBook, 2006 Small GTPases of the Ras superfamily are key regulators of diverse cellular and developmental events, including differentiation, cell division, vesicle transport, nuclear assembly, and control of the cytoskeleton. The C. elegans genome encodes 56 members of the major Ras GTPase subfamilies, including the Ras/Ral/Rap family, the Rho family, the Rab ...
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WormBook, 2018 Members of the protein superfamily of small guanosine triphosphatases, also known as small GTPases, small G-proteins, or the Ras superfamily, are involved in nearly every aspect of cell biology. Small GTPases are tightly regulated molecular switches that make binary on/off decisions through controlled loading of GTP (activation) and hydrolysis of GTP ...
David J, Reiner, Erik A, Lundquist
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A mechanism for the response of KRASG13D expressing colorectal cancers to EGFR inhibitors
Molecular & Cellular Oncology, 2020 Previous analysis of Phase 3 clinical trial data for colorectal cancer patients treated with cetuximab revealed that patients harboring a KRAS mutation did not benefit from treatment.
Thomas McFall, Edward Cooper Stites
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eLife, 2020 Ventral furrow formation, the first step in Drosophila gastrulation, is a well-studied example of tissue morphogenesis. Rho1 is highly active in a subset of ventral cells and is required for this morphogenetic event.
Ashley Rich +2 more
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The Impact of the Stringent Response on TRAFAC GTPases and Prokaryotic Ribosome Assembly
Cells, 2019 Many facets of ribosome biogenesis and function, including ribosomal RNA (rRNA) transcription, 70S assembly and protein translation, are negatively impacted upon induction of a nutrient stress-sensing signalling pathway termed the stringent response ...
Daniel J. Bennison +2 more
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A highly-sensitive high throughput assay for dynamin's basal GTPase activity. [PDF]
PLoS ONE, 2017 Clathrin-mediated endocytosis is the major pathway by which cells internalize materials from the external environment. Dynamin, a large multidomain GTPase, is a key regulator of clathrin-mediated endocytosis.
Aparna Mohanakrishnan +5 more
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Concerted Complex Assembly and GTPase Activation in the Chloroplast Signal Recognition Particle [PDF]
, 2011 The universally conserved signal recognition particle (SRP) and SRP receptor (SR) mediate the cotranslational targeting of proteins to cellular membranes.
Chandrasekar, Sowmya +4 more
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Current Protocols, 2023 AbstractIn different cellular activities like signal transduction, cell division, and intracellular transportation, small GTPases take on a vital role. Their functioning involves hydrolysing guanosine triphosphate (GTP) to guanosine diphosphate (GDP).
Sophie Tschirpke +2 more
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