Journal of Cell Biology, 2021 Borchers et al. review regulatory principles in the activation of endocytic Rab GTPases and how they apply to other Rab and Arf GTPases.
Ann-Christin Borchers +2 more
semanticscholar +1 more source
Targeting Rho GTPase Signaling Networks in Cancer
Frontiers in Cell and Developmental Biology, 2020 As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of cellular processes, including cell polarity, cell migration, and cell cycle progression.
Natasha S. Clayton, A. Ridley
semanticscholar +1 more source
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
Cell, 1992 Cecilia Bucci +6 more
openalex +2 more sources
Targeting the Small GTPase Superfamily through Their Regulatory Proteins
Angewandte Chemie, 2020 The Ras superfamily of small GTPases are guanine‐nucleotide‐dependent switches essential for numerous cellular processes. Mutations or dysregulation of these proteins are associated with many diseases, but unsuccessful attempts to target the small ...
J. Gray, F. Delft, P. Brennan
semanticscholar +1 more source
Concerted Complex Assembly and GTPase Activation in the Chloroplast Signal Recognition Particle [PDF]
, 2011 The universally conserved signal recognition particle (SRP) and SRP receptor (SR) mediate the cotranslational targeting of proteins to cellular membranes.
Chandrasekar, Sowmya +4 more
core +3 more sources
Conformational changes in the GTPase modules of the signal reception particle and its receptor drive initiation of protein translocation [PDF]
, 2007 During cotranslational protein targeting, two guanosine triphosphatase (GTPase) in the signal recognition particle (SRP) and its receptor (SR) form a unique complex in which hydrolyses of both guanosine triphosphates (GTP) are activated in a shared ...
Chandrasekar, Sowmya +2 more
core +4 more sources
Rho GTPase signaling complexes in cell migration and invasion
Journal of Cell Biology, 2018 Cell migration is dependent on the dynamic formation and disassembly of actin filament–based structures, including lamellipodia, filopodia, invadopodia, and membrane blebs, as well as on cell–cell and cell–extracellular matrix adhesions.
C. Lawson, A. Ridley
semanticscholar +1 more source
Signal Recognition Particle (SRP) and SRP Receptor: A New Paradigm for Multistate Regulatory GTPases [PDF]
, 2009 The GTP-binding proteins or GTPases comprise a superfamily of proteins that provide molecular switches in numerous cellular processes. The “GTPase switch” paradigm, in which a GTPase acts as a bimodal switch that is turned “on” and “off” by external ...
Schmid, Sandra L. +2 more
core +2 more sources
Developmental control of plant Rho GTPase nano-organization by the lipid phosphatidylserine
Science, 2019 GTPase clustering in response to a hormone Some lipid variants that are rare in plasma membranes function as signaling components. Studying root tip cells of the model plant Arabidopsis, Platre et al.
M. Platre +12 more
semanticscholar +1 more source
Novel regulation of mitotic exit by the Cdc42 effectors Gic1 and Gic2 [PDF]
, 2004 Copyright @ The Rockefeller University PressThe guanine nucleotide exchange factor Cdc24, the GTPase Cdc42, and the Cdc42 effectors Cla4 and Ste20, two p21-activated kinases, form a signal transduction cascade that promotes mitotic exit in yeast.
Höfken, T, Schiebel, E
core +2 more sources