Results 211 to 220 of about 322,041 (407)

MoMtg1 Acts as a Novel Transcriptional Repressor of MoSwi6 During Appressorium‐Mediated Penetration in the Rice Blast Fungus

Advanced Science, EarlyView.
Appressoria are specialized penetration structures for many plant pathogenic fungi, demanding precise cell cycle control. This study unveils MoMtg1 as a transcriptional repressor of MoSwi6, orchestrating MoCYC1 expression during turgor‐driven cell cycle progression to enable appressorium‐mediated penetration. Moreover, a small‐molecule inhibitor ZS1619
Xingyu Wang, Ting Zhang, Qi Li, Chang‐An Ji, Lin Huang, Mingzhi Zhang, Leiyun Yang, Xinyu Liu, Muxing Liu, Gang Li, Zhengguang Zhang, Haifeng Zhang   +11 more
wiley   +1 more source

Additional component required for activity and reconstitution of light-activated vertebrate photoreceptor GTPase.

, 1980
Takao Shinozawa, Shusaku Uchida, E. M. Martin, David S. Cafiso, Wayne L. Hubbell, Mark W. Bitensky   +5 more
openalex   +1 more source

Cardiac α₁‐adrenoceptors stimulate a high‐affinity GTPase activity in sarcolemmal membranes from rabbit atrial and ventricular myocytes [PDF]

, 1993
Andrew P. Braun, Michael P. Walsh
openalex   +1 more source

ARL3 Enhances ERα Stability via USP10 Deubiquitination to Promote Endocrine Resistance and Drive Mitochondrial Metabolic Reprogramming in HR+ Breast Cancer

Advanced Science, EarlyView.
This study identifies ADP‐ribosylation factor‐like protein 3 (ARL3) as a novel chaperone that stabilizes estrogen receptor α (ERα) in breast cancer. ARL3 promotes tumor growth by recruiting USP10 to remove ubiquitin chains from ERα, preventing its degradation.
Han Li, Yang Liu, Zehao Cai, Kang Li, Shun Gao, Ailin Lan, Dan Shu, Kuan He, Xin Liu, Yang Peng, Shipeng Guo, Haochen Yu, Aishun Jin, Meiying Shen, Shengchun Liu   +14 more
wiley   +1 more source

Procyanidin B3 and Its Derivatives Alleviate Neuronal Injury by Targeting G3BP1 for Ischemic Stroke Therapy

Advanced Science, EarlyView.
Ischemic stroke is a serious disease with high rates of mortality and disability, but there is a lack of novel therapeutic targets and agents for it. Now it is shown that Ras GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1) has the potential to serve as a therapeutic target for ischemic stroke.
Heyanhao Zhang, Yuyu Zhang, Yibo Chen, Wen Zhong, Subei Tan, Jinghuan Wang, Huanren Yan, Ning Yan, Mengjia Lin, Xinhua Liu, Jun Chang   +10 more
wiley   +1 more source

Polycystin‐1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1‐Dependent Microfilament Remodeling

Advanced Science, EarlyView.
Polycystin‐1 (PC1) senses collagen and ECM stiffness to promote tumor migration via Daam1‐mediated actin remodeling. A cleavage‐resistant PC1 mutant enhances YAP nuclear translocation and CTGF expression, which activates CAFs and further stiffens the ECM, forming a feed‐forward loop that drives tumor progression and metastasis.
Jiaofeng Zhou, Yibing Deng, Jie Mei, Mengyun Wan, Ningyi Xue, Xinyu Zong, Ji Zhou, Junli Ding, Ting Yan, Yu Jiang, Tiansong Xia, Peng Zheng, Yichao Zhu   +12 more
wiley   +1 more source

The kyotorphin (Tyrosine-Arginine) Receptor and a Selective Reconstitution with Purified Gi, Measured with GTPase and Phospholipase C Assays

, 1989
Hiroshi Ueda, Yoshihiro Yoshihara, Hidemi Misawa, Noriyasu Fukushima, Toshiaki Katada, M Ui, Hiroshi Takagi, Masamichi Satoh   +7 more
openalex   +1 more source

Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway

Proceedings of the National Academy of Sciences of the United States of America, 2018
Minji Lee, J. H. Kim, Ina Yoon, C. Lee, Mohammad Fallahi Sichani, J. Kang, Jeonghyun Kang, Min Guo, Kang Young Lee, G. Han, Sunghoon Kim, J. Han   +11 more
semanticscholar   +1 more source

Sonoepigenetic Modification Mechanoprimes Early Osteogenic Commitment in Mesenchymal Stem Cells

Advanced Science, EarlyView.
Brief 10 min bursts of high frequency (10 MHz) vibrational mechanostimulation to stem cells are shown to activate their epigenetic machinery to condition their differentiation down an osteogenic lineage within just 3 days, which is much earlier than that with other forms of mechanostimuli, and without requiring any biochemical additives. Abstract Cells
Lizebona A. Ambattu, Blanca del Rosal, Carmelo Ferrai, Leslie Y. Yeo   +3 more
wiley   +1 more source

Identification and partial purification of GTPase‐activating proteins from yeast and mammalian cells that preferentially act on Ypt1/Rab1 proteins [PDF]

, 1991
Tjie J. Tan, Petra Vollmer, Dieter Gallwitz   +2 more
openalex   +1 more source