A Rho family GTPase controls actin dynamics and tip growth via two counteracting downstream pathways in pollen tubes. [PDF]
Tip growth in neuronal cells, plant cells, and fungal hyphae is known to require tip-localized Rho GTPase, calcium, and filamentous actin (F-actin), but how they interact with each other is unclear.
Dowd, Peter +6 more
core +3 more sources
The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility [PDF]
Vaccinia virus dissemination relies on the N-WASP– ARP2/3 pathway, which mediates actin tail formation underneath cell-associated extracellular viruses (CEVs).
Alberts +79 more
core +2 more sources
Review: Translational GTPases [PDF]
ABSTRACTTranslational GTPases (trGTPases) play key roles in facilitating protein synthesis on the ribosome. Despite the high degree of evolutionary conservation in the sequences of their GTP‐binding domains, the rates of GTP hydrolysis and nucleotide exchange vary broadly between different trGTPases.
Maracci, Cristina, Rodnina, Marina V.
openaire +2 more sources
Identifying conformational changes with site-directed spin labeling reveals that the GTPase domain of HydF is a molecular switch [PDF]
[FeFe]-hydrogenases catalyse the reduction of protons to hydrogen at a complex 2Fe[4Fe4S] center called H-cluster. The assembly of this active site is a multistep process involving three proteins, HydE, HydF and HydG.
Acquasaliente, Laura +8 more
core +1 more source
Regulation of polarised growth in fungi [PDF]
Polarised growth in fungi occurs through the delivery of secretory vesicles along tracks formed by cytoskeletal elements to specific sites on the cell surface where they dock with a multiprotein structure called the exocyst before fusing with the ...
Adamo +112 more
core +1 more source
Small GTPases in platelet membrane trafficking
Our understanding of fundamental biological processes within platelets is continually evolving. A critical feature of platelet biology relates to the intricate uptake, packaging and release of bioactive cargo from storage vesicles, essential in mediating
Tony G. Walsh +3 more
doaj +1 more source
Small G-proteins (RAC and RHO) are known to be involved in regulation of superoxide (O2*-) production and the assembly of actin fibres. These processes are known to be crucial for accessibility and inaccessibility of barley cells to the biotrophic fungus
H. Schultheiss +3 more
doaj +1 more source
Conformational changes in the GTPase modules of the signal reception particle and its receptor drive initiation of protein translocation [PDF]
During cotranslational protein targeting, two guanosine triphosphatase (GTPase) in the signal recognition particle (SRP) and its receptor (SR) form a unique complex in which hydrolyses of both guanosine triphosphates (GTP) are activated in a shared ...
Chandrasekar, Sowmya +2 more
core +4 more sources
Dynamin-catalyzed membrane fission requires coordinated GTP hydrolysis. [PDF]
Dynamin is the most-studied membrane fission machinery and has served as a paradigm for studies of other fission GTPases; however, several critical questions regarding its function remain unresolved.
Ya-Wen Liu +2 more
doaj +1 more source
Actin’ up: Herpesvirus Interactions with Rho GTPase Signaling
Herpesviruses constitute a very large and diverse family of DNA viruses, which can generally be subdivided in alpha-, beta- and gammaherpesvirus subfamilies.
Herman W. Favoreel +1 more
doaj +1 more source

